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相关论文
6Menopausal hormone therapy and breast cancer risk: a population-based cohort study of 1.3 million women in Norway
Nathalie C. Støer•Siri Vangen•Deependra Singh•Renée T. Fortner•Solveig Hofvind等 7 人
British Journal Of Cancer
2024
•2024/5/13
•00 p.1-12
It is important to monitor the association between menopausal hormone therapy (HT) use and breast cancer (BC) risk with contemporary estimates, and specifically focus on HT types and new drugs. We estimated hazard ratios (HR) of BC risk according to HT type, administration route and individual drugs...
Breast cancerRisk factors
10.1038/S41416-024-02590-1
ISSN:0007-0920
Genome-wide association studies of infant and toddler temperament in European and multi-ancestry populations
Anja Hollowell•Anna Gui•Emilie Wigdor•Morgan J. Morgan•Laurie J. Hannigan等 34 人
Nature Human Behaviour
2026
•2026/7/1
•00 p.1-20
Early temperament, such as socio-emotional development and activity level, varies widely, yet its underlying biological associations are not understood. We identified genetic variation associated with infant and toddler temperament using genome-wide association meta-analyses. We studied parent-rated...
Behavioural geneticsHuman behaviour
10.1038/S41562-026-02486-5
ISSN:2397-3374
Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry
Anna Gui•Anja Hollowell•Emilie M. Wigdor•Morgan J. Morgan•Laurie J. Hannigan等 28 人
Nature Human Behaviour
2025
•2025/5/7
•00 p.1-18
Age at onset of walking is an important early childhood milestone which is used clinically and in public health screening. In this genome-wide association study meta-analysis of age at onset of walking (N = 70,560 European-ancestry infants), we identified 11 independent genome-wide significant loci....
DevelopmentHuman behaviour
10.1038/S41562-025-02145-1
ISSN:2397-3374
Associations of polygenic risk scores for major depression and depression severity: an investigation of 105 623 individuals with 16 years follow-up
Marit Haram•Andreas Jangmo•Piotr Jaholkowski•Joëlle Pasman•Joeri Meijsen等 15 人
Molecular Psychiatry
2025
•2025/9/17
•00 p.1-8
Genetic risk could be informative for identifying individuals at risk of depression with severe outcomes. With the novel approach of combined health care registries and self-report measures related to depression, the authors aimed to identify the impact of polygenic risk scores (PRS) for major depre...
BiomarkersDepression
10.1038/S41380-025-03243-2
ISSN:1359-4184
Fatal and non-fatal breast cancers in women targeted by BreastScreen Norway: a cohort study
Kaitlyn M. Tsuruda•Solveig Roth Hoff•Lars A. Akslen•Solveig Hofvind
British Journal Of Cancer
2023
•2023/12/4
•00 p.1-9
Many breast cancer survivors experience anxiety related to dying from their disease even if it is detected at an early stage. We aimed to increase knowledge about fatal and non-fatal breast cancer by describing how histopathological tumour profiles and detection modes were associated with 10-year br...
Breast cancerEpidemiologyPopulation screeningRisk factors
10.1038/S41416-023-02512-7
ISSN:0007-0920
A genome-wide association study provides insights into the genetic etiology of 57 essential and non-essential trace elements in humans
Marta R. Moksnes•Ailin F. Hansen•Brooke N. Wolford•Laurent F. Thomas•Humaira Rasheed等 24 人
Communications Biology
2024
•2024/4/9
•Vol.7 No.1 p.1-14
Trace elements are important for human health but may exert toxic or adverse effects. Mechanisms of uptake, distribution, metabolism, and excretion are partly under genetic control but have not yet been extensively mapped. Here we report a comprehensive multi-element genome-wide association study of...
Genome-wide association studiesRisk factors
10.1038/S42003-024-06101-Z
ISSN:2399-3642