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5Waxholm Space atlas of the rat brain: a 3D atlas supporting data analysis and integration
Heidi Kleven•Ingvild E. Bjerke•Francisco Clascá•Henk J. Groenewegen•Jan G. Bjaalie等 6 人
Nature Methods
2023
•2023/10/2
•00 p.1-8
Volumetric brain atlases are increasingly used to integrate and analyze diverse experimental neuroscience data acquired from animal models, but until recently a publicly available digital atlas with complete coverage of the rat brain has been missing. Here we present an update of the Waxholm Space r...
Cellular neuroscienceComputational neuroscienceRat
10.1038/S41592-023-02034-3
ISSN:1548-7091
Stimulation mapping and whole-brain modeling reveal gradients of excitability and recurrence in cortical networks
Davide Momi•Zheng Wang•Sara Parmigiani•Ezequiel Mikulan•Sorenza P. Bastiaens等 13 人
Nature Communications
2025
•2025/4/4
•Vol.16 No.1 p.1-12
The human brain exhibits a modular and hierarchical structure, spanning low-order sensorimotor to high-order cognitive/affective systems. What is the mechanistic significance of this organization for brain dynamics and information processing properties? We investigated this question using rare simul...
Computational neuroscienceNeuroscience
10.1038/S41467-025-58187-6
ISSN:2041-1723
Prediction of DNA methylation-based tumor types from histopathology in central nervous system tumors with deep learning
Danh-Tai Hoang•Eldad D. Shulman•Rust Turakulov•Zied Abdullaev•Omkar Singh等 11 人
Nature Medicine
2024
•2024/5/17
•00 p.1-10
Precision in the diagnosis of diverse central nervous system (CNS) tumor types is crucial for optimal treatment. DNA methylation profiles, which capture the methylation status of thousands of individual CpG sites, are state-of-the-art data-driven means to enhance diagnostic accuracy but are also tim...
CNS cancerEpigenomicsMachine learning
10.1038/S41591-024-02995-8
ISSN:1078-8956
Siibra: a software tool suite for realizing a Multilevel Human Brain Atlas from complex data resources
Timo Dickscheid•Xiaoyun Gui•Ahmet N. Simsek•Christian Schiffer•Jean-Francois Mangin等 11 人
Nature Methods
2026
•2026/7/20
•00 p.1-12
Computational technology opens new possibilities toward understanding the complexity of the human brain, but it requires integrating measurements from different modalities and scales in an anatomical context and exposing them in an interoperable, actionable form. Especially with growing big data res...
Computational neuroscienceData integrationNeuroscienceSoftware
10.1038/S41592-026-03159-X
ISSN:1548-7091
DeMBA: a developmental atlas for navigating the mouse brain in space and time
Harry Carey•Heidi Kleven•Martin Øvsthus•Sharon C. Yates•Gergely Csucs等 10 人
Nature Communications
2025
•2025/8/29
•Vol.16 No.1 p.1-13
Studies of the adult mouse brain have benefited from three-dimensional (3D) atlases providing standardised frameworks for data analysis and integration. However, few 3D atlases exist for the developing mouse brain, and none cover more than a few ages. This fails to represent the dynamic nature of de...
Computational neuroscienceDevelopment of the nervous systemNeuroscience
10.1038/S41467-025-63177-9
ISSN:2041-1723