DH016
Peter A Sims
2025
2025/3/11
United States, Cabin John
Columbia University
数据描述

This dataset comprises human T cell transcriptomic data from the GEO series on infant and adult T cells across tissues, with this sample representing unstimulated spleen-derived T cells from a 0.75-year-old female donor. It contains single-cell RNA-seq profiles generated from negatively selected pan T cells using the 10x Genomics Chromium platform and Illumina NovaSeq 6000 sequencing, with processed gene expression count matrices aligned to GRCh38. The data support analysis of T cell states, diversity, and tissue-specific immune characteristics across human development and anatomical sites.
关键词
1Homo sapiens
www.ncbi.nlm.nih.gov
IP: 130.14.29.110
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相关论文
1Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells
Peter A. Szabo•Hanna M. Levitin•Siddhi Nargund•Thomas J. Connors•David Chen等 16 人
Nature Immunology
2026
•2026/6/2
•00 p.1-11
Early life is essential for establishing memory T cells, which rapidly populate mucosal sites during infancy, although these nascent memory T cells are less protective than their adult counterparts. Here we used single-cell RNA sequencing of resting and CD3+CD28 antibody-stimulated T cells from lymp...
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ISSN:1529-2908