Allen Human Brain Atlas Microarray Data
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数据描述

Allen Human Brain Atlas Microarray Data

The Allen Human Brain Atlas microarray dataset is an “all genes, all structures” gene expression survey of multiple adult control human brains. It contains genome-wide microarray profiles with over 62,000 gene probes per sample, collected from roughly 500 anatomically distributed samples per hemisphere spanning cerebrum, cerebellum, and brainstem. Expression measurements are mapped to brain anatomy using histology and registered into a unified 3D anatomical framework based on MRI, enabling spatial analysis across structures. The dataset supports gene-centric searches, browsing by functional and disease-related categories, and correlation analyses to identify genes with similar spatial expression patterns for neuroanatomical and neurogenomic research.

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Neurogenetic profiles delineate large-scale connectivity dynamics of the human brain

Ibai DiezJorge Sepulcre
Nature Communications
2018
2018/9/24
Vol.9 No.1 p.1-10
Experimental and modeling work of neural activity has described recurrent and attractor dynamic patterns in cerebral microcircuits. However, it is still poorly understood whether similar dynamic principles exist or can be generalizable to the large-scale level. Here, we applied dynamic graph theory-...
Cognitive neuroscienceGenetics of the nervous systemNetwork modelsNeuroscience
10.1038/S41467-018-06346-3
ISSN:2041-1723

Regional gene expression and brain atrophy in dementia with Lewy bodies: an imaging transcriptomics study

Annegret HabichJanna M. BaumannChristopher G. SchwarzScott A. PrzybelskiAnna Inguanzo16
Npj Parkinson's Disease
2026
2026/4/16
Vol.12 No.1 p.960
Regional brain atrophy has been observed in dementia with Lewy bodies (DLB), yet determinants of regional vulnerability remain unclear. Using imaging transcriptomics, we examined whether normative gene expression patterns relate to regional atrophy in DLB. We included 164 DLB patients (49 women) and...
BiomarkersDiseasesNeurologyNeuroscience
10.1038/S41531-026-01355-2
ISSN:2373-8057

Decoding the striatum of drug-naive patients with obsessive-compulsive disorder: a transcriptome and longitudinal functional magnetic resonance imaging study

Yiding HanHaohao YanXiaoxiao ShanHuabing LiFeng Liu9
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2025
2025/7/28
Vol.15 No.1 p.1-14
The striatum’s role in obsessive-compulsive disorder (OCD) pathology is recognized. However, the specific contributions of individual striatal subregions (SSs) to OCD pathology are underexplored. We recruited 49 drug-naive OCD patients and 53 healthy controls, conducting clinical assessments and res...
Epigenetics in the nervous systemGenomicsHuman behaviourPsychiatric disorders
10.1038/S41398-025-03475-4
ISSN:2158-3188

Neurophysiological signatures of cortical micro-architecture

Golia ShafieiBen D. FulcherBradley VoytekTheodore D. SatterthwaiteSylvain Baillet6
Nature Communications
2023
2023/9/26
Vol.14 No.1 p.1-15
Systematic spatial variation in micro-architecture is observed across the cortex. These micro-architectural gradients are reflected in neural activity, which can be captured by neurophysiological time-series. How spontaneous neurophysiological dynamics are organized across the cortex and how they ar...
Biophysical modelsNetwork models
10.1038/S41467-023-41689-6
ISSN:2041-1723

Transcriptome-informed brain cartography of polygenic risk and association with brain structure in major psychiatric disorders

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Molecular Psychiatry
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2026/3/6
00 p.1-13
Psychiatric disorders are complex, polygenic conditions characterized by patterned structural brain alterations. Whether these changes reflect transcriptional dysregulation driven by genetic risk remains unclear. We introduce a novel imaging-transcriptomics framework that integrates transcriptome-wi...
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Tau propagation in the brain olfactory circuits is associated with smell perception changes in aging

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Nature Communications
2024
2024/6/6
Vol.15 No.1 p.1-13
The direct access of olfactory afferents to memory-related cortical systems has inspired theories about the role of the olfactory pathways in the development of cortical neurodegeneration in Alzheimer’s disease (AD). In this study, we used baseline olfactory identification measures with longitudinal...
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Spatiotemporal patterns of locus coeruleus integrity predict cortical tau and cognition

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Nature Aging
2024
2024/4/25
00 p.1-13
Autopsy studies indicated that the locus coeruleus (LC) accumulates hyperphosphorylated tau before allocortical regions in Alzheimer’s disease. By combining in vivo longitudinal magnetic resonance imaging measures of LC integrity, tau positron emission tomography imaging and cognition with autopsy d...
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10.1038/S43587-024-00626-Y
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Opportunities and pitfalls of data contextualization in neuroimaging

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Nature Reviews Neuroscience
2026
2026/4/2
00 p.1-19
Understanding the mechanisms of brain function and dysfunction is at the core of the neuroscience mission. However, the field’s grasp of causal relationships between brain properties has been hindered by a focus on single modalities that neglects the complex interplay between the features found at d...
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10.1038/S41583-026-01038-0
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Local molecular and global connectomic contributions to cross-disorder cortical abnormalities

Hansen Justine Y.Shafiei GoliaVogel Jacob W.Smart KellyBearden Carrie E.29
Nature Communications
2022
2022/8/10
Vol.13 No.1 p.1-17
Numerous brain disorders demonstrate structural brain abnormalities, which are thought to arise from molecular perturbations or connectome miswiring. The unique and shared contributions of these molecular and connectomic vulnerabilities to brain disorders remain unknown, and has yet to be studied in...
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10.1038/S41467-022-32420-Y
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Neurodevelopmentally rooted epicenters in schizophrenia: sensorimotor-association spatial axis of cortical thickness alterations

Yun-Shuang FanYong XuMeike Dorothee HettwerPengfei YangWei Sheng10
Molecular Psychiatry
2025
2025/8/28
00 p.1-12
Pathological disturbances in schizophrenia have been suggested to propagate via the functional and structural connectome across the lifespan. However, how the connectome guides early cortical reorganization of developing schizophrenia remains unknown. Here, we used early-onset schizophrenia (EOS) as...
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10.1038/S41380-025-03193-9
ISSN:1359-4184

Using coding and non-coding rare variants to target candidate genes in patients with severe tinnitus

Gallego-Martinez AlvaroEscalera-Balsera AlbaTrpchevska NataliaRobles-Bolivar PaulaRoman-Naranjo Pablo12
Npj Genomic Medicine
2022
2022/11/30
Vol.7 No.1 p.1-9
Tinnitus is the phantom percept of an internal non-verbal set of noises and tones. It is reported by 15% of the population and it is usually associated with hearing and/or brain disorders. The role of structural variants (SVs) in coding and non-coding regions has not been investigated in patients wi...
Diagnostic markersGenetics research
10.1038/S41525-022-00341-W
ISSN:2056-7944

Associated transcriptional, brain and clinical variations in schizophrenia

Long-Biao CuiShu-Wan ZhaoYa-Hong ZhangKun ChenYu-Fei Fu18
Nature Mental Health
2024
2024/9/9
00 p.1-11
Understanding the relationship between genetic variations and brain abnormalities is crucial for uncovering the cross-scale pathophysiological mechanisms underlying schizophrenia. This cross-sectional study identifies brain structural correlates of individual variation in gene expression in schizoph...
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CYP1B1-RMDN2 Alzheimer’s disease endophenotype locus identified for cerebral tau PET

Kwangsik NhoShannon L. RisacherLiana G. ApostolovaPaula J. BiceJared R. Brosch59
Nature Communications
2024
2024/9/20
Vol.15 No.1 p.1-14
Determining the genetic architecture of Alzheimer’s disease pathologies can enhance mechanistic understanding and inform precision medicine strategies. Here, we perform a genome-wide association study of cortical tau quantified by positron emission tomography in 3046 participants from 12 independent...
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ISSN:2041-1723

Neurocognitive and hypokinetic movement disorder with features of parkinsonism after BCMA-targeting CAR-T cell therapy

Van Oekelen OliverAleman AdolfoUpadhyaya BhaskarSchnakenberg SandraMadduri Deepu17
Nature Medicine
2021
2021/12/10
Vol.27 No.12 p.2099-2103
B-cell maturation antigen (BCMA) is a prominent tumor-associated target for chimeric antigen receptor (CAR)-T cell therapy in multiple myeloma (MM). Here, we describe the case of a patient with MM who was enrolled in the CARTITUDE-1 trial ( NCT03548207 ) and who developed a progressive movement diso...
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Abnormal cortical topographic patterns associated with auditory verbal hallucination in first-episode schizophrenia

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Translational Psychiatry
2025
2025/11/27
0
Convergent phenomenological and neuroimaging evidence support that the dysregulated segregation and integration between brain networks have been implicated in the neural mechanism of auditory verbal hallucination (AVH) in schizophrenia. Nevertheless, the macroscale topographical alterations of funct...
BiomarkersSchizophrenia
10.1038/S41398-025-03748-Y
ISSN:2158-3188

Cortical thinning and hippocampal expansion as brain signatures of attention deficit hyperactivity disorder symptom trajectories

Wenjie HouDaqian ZhuBarbara J. SahakianSamuele CorteseChristelle Langley34
Nature Mental Health
2026
2026/2/10
Vol.4 No.2 p.263-278
Clinical heterogeneity in the symptom trajectories of attention deficit hyperactivity disorder (ADHD) is well documented, but their neurodevelopmental mechanisms remain unclear. We used a longitudinal cohort of adolescents (ABCD; n = 7,436) to show that persistent, remitting and emergent ADHD sympto...
ADHDPredictive markersPsychology
10.1038/S44220-025-00578-1
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Open datasets and code for multi-scale relations on structure, function and neuro-genetics in the human brain

Antonio Jimenez-MarinIbai DiezAsier ErramuzpeSebastiano StramagliaPaolo Bonifazi6
Scientific Data
2024
2024/2/29
Vol.11 No.1 p.1-11
The human brain is an extremely complex network of structural and functional connections that operate at multiple spatial and temporal scales. Investigating the relationship between these multi-scale connections is critical to advancing our comprehension of brain function and disorders. However, acc...
Biomedical engineeringNetwork models
10.1038/S41597-024-03060-2
ISSN:2052-4463

Connectome-based growth models reveal individual heterogeneity and neurophysiological subtypes of subthreshold depression

Guanmao ChenXiaoyi SunPan ChenXuan BuZhangzhang Qi34
Molecular Psychiatry
2026
2026/2/10
00 p.1-11
Subthreshold depression (StD) confers a high risk for major depression and is characterized by substantial individual clinical heterogeneity. However, the neurobiological substrates underlying this heterogeneity remain largely unknown. Using a large multisite resting-state functional MRI dataset inc...
DepressionNeuroscience
10.1038/S41380-026-03457-Y
ISSN:1359-4184

Transcriptional and imaging-genetic association of cortical interneurons, brain function, and schizophrenia risk

Kevin M. AndersonMeghan A. CollinsRowena ChinTian GeMonica D. Rosenberg6
Nature Communications
2020
2020/6/8
Vol.11 No.1 p.1-15
Inhibitory interneurons orchestrate information flow across the cortex and are implicated in psychiatric illness. Although interneuron classes have unique functional properties and spatial distributions, the influence of interneuron subtypes on brain function, cortical specialization, and illness ri...
Cognitive neuroscienceGene expressionSchizophrenia
10.1038/S41467-020-16710-X
ISSN:2041-1723

Assortative mixing in micro-architecturally annotated brain connectomes

Vincent BazinetJustine Y. HansenReinder Vos de WaelBoris C. BernhardtMartijn P. van den Heuvel6
Nature Communications
2023
2023/5/18
Vol.14 No.1 p.1-16
The wiring of the brain connects micro-architecturally diverse neuronal populations, but the conventional graph model, which encodes macroscale brain connectivity as a network of nodes and edges, abstracts away the rich biological detail of each regional node. Here, we annotate connectomes with mult...
Computational neuroscienceNetwork models
10.1038/S41467-023-38585-4
ISSN:2041-1723

Herpes simplex virus 1 evades APOBEC1-mediated immunity via its uracil-DNA glycosylase in mice

Akihisa KatoHayato HarimaYuji TsunekawaManabu IgarashiKouichi Kitamura21
Nature Microbiology
2025
2025/6/3
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Herpes simplex virus 1 (HSV-1) is the most common cause of viral encephalitis, which can be lethal or result in severe neurological defects despite antiviral therapy. The apolipoprotein B messenger-RNA editing enzyme, catalytic polypeptide-like (APOBEC) group of proteins can act as viral restriction...
Herpes virusImmune evasion
10.1038/S41564-025-02026-3
ISSN:2058-5276

Beyond fear circuits: multiscale neurobiological architecture of panic disorder

Katharina A. ZientekJuergen DukartSarah KreuzerKatrin SakreidaMario Rastätter11
Molecular Psychiatry
2026
2026/5/27
00 p.1-11
Panic disorder is a prevalent and disabling condition marked by recurrent panic attacks and high treatment resistance. While previous research has focused on dysfunction within canonical fear circuits, the neurobiological basis of panic disorder may involve broader alterations across multiple brain ...
NeurosciencePsychiatric disorders
10.1038/S41380-026-03661-W
ISSN:1359-4184

Emotion dysregulation and right pars orbitalis constitute a neuropsychological pathway to attention deficit hyperactivity disorder

Wenjie HouBarbara J. SahakianChristelle LangleyYuqing YangR. A. I. Bethlehem6
Nature Mental Health
2024
2024/5/13
00 p.1-13
Emotion dysregulation is common in attention deficit hyperactivity disorder (ADHD), which is known to be clinically heterogeneous. However, it remains unclear whether emotion dysregulation represents a neuropsychological pathway to ADHD. Here, using a large population-based cohort (n = 6,053), we sh...
ADHDBrain imaging
10.1038/S44220-024-00251-Z
ISSN:2731-6076

An evolutionary timeline of the oxytocin signaling pathway

Alina M. SartoriusJaroslav RokickiSiri BirkelandFrancesco BettellaClaudia Barth17
Communications Biology
2024
2024/4/17
Vol.7 No.1 p.1-13
Oxytocin is a neuropeptide associated with both psychological and somatic processes like parturition and social bonding. Although oxytocin homologs have been identified in many species, the evolutionary timeline of the entire oxytocin signaling gene pathway has yet to be described. Using protein seq...
EndocrinologyEvolution
10.1038/S42003-024-06094-9
ISSN:2399-3642

Neuroimaging and multiomics reveal cross-scale circuit abnormalities in schizophrenia

Meng WangHao YanXiaohan TianWeihua YueYong Liu30
Nature Mental Health
2023
2023/8/28
00 p.1-22
Schizophrenia (SCZ) is a highly heterogeneous disorder with diverse clinical manifestations and macro- and microscale biological variations, usually observed at dissociable levels. Here we propose a cross-scale, circuit-based framework to connect heterogeneous clinical symptoms, large-scale brain ci...
Data integrationFunctional magnetic resonance imagingMagnetic resonance imagingSchizophrenia
10.1038/S44220-023-00110-3
ISSN:2731-6076

The application of amplitude of low-frequency fluctuations metrics in the diagnosis and prediction of treatment response as well as their associated genes and biological processes in patients with bipolar disorder

Leyi ZhangHaohao YanChunguo ZhangXiaoling LiJiaquan Liang10
Translational Psychiatry
2025
2025/10/31
Vol.15 No.1 p.1-13
While previous studies have reported functional abnormalities in the prefrontal-limbic-subcortical circuit, the treatment effects on this activity remain unclear. This longitudinal study aimed to investigate spontaneous brain activity in bipolar disorder patients (BDPs) at baseline and after treatme...
BiomarkersBipolar disorder
10.1038/S41398-025-03673-0
ISSN:2158-3188

General anaesthesia decreases the uniqueness of brain functional connectivity across individuals and species

Andrea I. LuppiDaniel GolkowskiAndreas RanftRudiger IlgDenis Jordan11
Nature Human Behaviour
2025
2025/3/24
00 p.1-18
The human brain is characterized by idiosyncratic patterns of spontaneous thought, rendering each brain uniquely identifiable from its neural activity. However, deep general anaesthesia suppresses subjective experience. Does it also suppress what makes each brain unique? Here we used functional MRI ...
ConsciousnessNetwork models
10.1038/S41562-025-02121-9
ISSN:2397-3374

Aberrant brain activity in pedophilia links to receptor distribution, gene expression, and behavior

Gereon J. SchnellbächerJuergen DukartJustine Y. HansenRoss D. MarkelloAndreas Mokros11
Nature Mental Health
2023
2023/8/14
00 p.1-8
Despite an estimated lifetime prevalence of 0.5–1.0% in men and high public concern, no effective treatment is known for pedophilic disorder. Here, we provide robust meta-analytic evidence that brain activity is not generally altered in pedophilia but deviates specifically in response to sexual stim...
BrainPsychiatric disordersSexual behaviour
10.1038/S44220-023-00105-0
ISSN:2731-6076

Subtyping psychotic disorders using a data-driven approach reveals divergent cortical and cellular signatures

Lauren D. HillXi-Han ZhangBaxter P. RogersAnna S. HuangVictoria Fox9
Molecular Psychiatry
2026
2026/7/23
00 p.1-11
Structural brain abnormalities in psychosis are well-replicated but heterogenous posing a barrier to uncovering the pathophysiology, etiology, and treatment of psychosis. To parse neurostructural heterogeneity and assess for the presence of anatomically-derived subtypes, we applied a data-driven met...
NeurosciencePsychiatric disorders
10.1038/S41380-026-03774-2
ISSN:1359-4184

Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys

Bo TingtingLi JieHu GanluZhang GeWang Wei13
Nature Communications
2023
2023/3/17
Vol.14 No.1 p.1-15
Integrative analyses of transcriptomic and neuroimaging data have generated a wealth of information about biological pathways underlying regional variability in imaging-derived brain phenotypes in humans, but rarely in nonhuman primates due to the lack of a comprehensive anatomically-defined atlas o...
Computational neuroscienceGenetics of the nervous system
10.1038/S41467-023-37246-W
ISSN:2041-1723

A nuclei-specific fronto-amygdala pathway and its neurotransmitter receptor distribution: Implications for Antidepressant Selection

Li XueTing WangJunneng ShaoXinyi WangLingling Hua8
Molecular Psychiatry
2026
2026/2/26
00 p.1-12
The amygdala and its cortical connections play an important role in antidepressant treatment of major depressive disorder (MDD). While it can be subdivided according to its cortical connections, the anatomical and molecular heterogeneity across these subdivisions in MDD patients responding to differ...
DepressionGeneticsPredictive markers
10.1038/S41380-026-03502-W
ISSN:1359-4184

Mapping histamine pathway networks in the human brain across cognition and psychiatric disorders

Daniel MartinsMattia VeroneseDaniel van WamelenLing ShanOliver Howes8
Nature Mental Health
2026
2026/5/12
Vol.4 No.5 p.816-828
Histamine is a key neuromodulator shaping cognition, emotion and behavioral flexibility, yet its organization in the human brain remains incompletely characterized. We conducted a multimodal analysis integrating transcriptomic, neuroimaging, developmental and functional datasets to map the architect...
Gene regulatory networksMagnetic resonance imaging
10.1038/S44220-026-00637-1
ISSN:2731-6076

Deciphering spatial domains from spatially resolved transcriptomics with an adaptive graph attention auto-encoder

Dong KangningZhang Shihua
Nature Communications
2022
2022/4/1
Vol.13 No.1 p.1-12
Recent advances in spatially resolved transcriptomics have enabled comprehensive measurements of gene expression patterns while retaining the spatial context of the tissue microenvironment. Deciphering the spatial context of spots in a tissue needs to use their spatial information carefully. To this...
Classification and taxonomyComputational modelsData miningFunctional clusteringSoftware
10.1038/S41467-022-29439-6
ISSN:2041-1723

Transcriptomic profiles link corticostriatal microarchitecture to genetics of neurodevelopment and neuropsychiatric risks

Sheng HuYanming WangXiaoxiao WangYang JiChuanfu Li6
Translational Psychiatry
2025
2025/2/11
Vol.15 No.1 p.1-10
Many studies on macroscale organization have focused on only the cerebral cortex or striatum, leaving a large gap in the microstructural gradient of corticostriatal covariance. Here, we partitioned the striatum into seven distinct parcels and computed the microstructural covariance between each parc...
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ISSN:2158-3188

Coordinated cortical thickness alterations across six neurodevelopmental and psychiatric disorders

Hettwer M. D.Larivière S.Park B. Y.van den Heuvel O. A.Schmaal L.21
Nature Communications
2022
2022/11/11
Vol.13 No.1 p.1-14
Neuropsychiatric disorders are increasingly conceptualized as overlapping spectra sharing multi-level neurobiological alterations. However, whether transdiagnostic cortical alterations covary in a biologically meaningful way is currently unknown. Here, we studied co-alteration networks across six ne...
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ISSN:2041-1723

Connectivity of the adult human brain with sequential neurogenesis of circuits and transcriptomics signatures

Ibai DiezFernando García-MorenoNayara Carral-SainzSebastiano StramagliaAlicia Nieto-Reyes8
Nature Communications
2025
2025/12/31
0
Understanding the architectural principles that shape human brain networks is a major challenge for systems neuroscience. We hypothesize that the centrality of the different brain circuits in the human connectome is a product of their embryogenic age, such that early-born nodes should become stronge...
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10.1038/S41467-025-67785-3
ISSN:2041-1723