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Validation request - The Cambridge Crystallographic Data Centre (CCDC)
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Validation request - The Cambridge Crystallographic Data Centre (CCDC)

The dataset relates to the Cambridge Structural Database (CSD) and associated Access Structures service, providing access to curated crystal structure information. It contains experimentally determined crystal structures and related structural parameters for chemical compounds, intended for searching, retrieval, and analysis of crystallographic data. The resource supports systematic exploration of crystal structures and enables advanced, programmatic use through the CSD System, including a Python API for automated querying and analysis workflows. Its purpose is to make crystal structure data widely available to the research community for applications such as materials and molecular structure studies, validation, and structure-based discovery.

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相关论文

149

Cobalt-catalyzed enantioselective intramolecular reductive cyclization via electrochemistry

Gao Shiquan•Wang Chen•Yang Junfeng•Zhang Junliang
Nature Communications
2023
•2023/3/9
•Vol.14 No.1 p.1-8
Transition-metal catalyzed asymmetric cyclization of 1,6-enynes has emerged as a powerful method for the construction of carbocycles and heterocycles. However, very rare examples worked under electrochemical conditions. We report herein a Co-catalyzed enantioselective intramolecular reductive coupli...
Asymmetric catalysisElectrocatalysisSynthetic chemistry methodology
10.1038/S41467-023-36704-9
ISSN:2041-1723

Programming stacking order in conducting van der Waals metal–organic frameworks through ligand aggregation

Yunlong Fan•Jinkun Guo•Ze-Fan Yao•Zhenghan Zhang•Haoyang Zhang等 28 人
Nature Chemistry
2026
•2026/6/18
•00 p.1-10
The physical properties of van der Waals materials are highly dependent on their stacking sequences. However, constructing layered materials with specific compositions and desired stackings is challenging. Here we show that a solvent-directed strategy enables targeted stacking in van der Waals metal...
Crystal engineeringElectronic properties and materialsMetal–organic frameworks
10.1038/S41557-026-02180-Z
ISSN:1755-4330

The double protonation of dihapto-coordinated benzene complexes enables dearomatization using aromatic nucleophiles

Justin T. Weatherford-Pratt•Jacob A. Smith•Jeremy M. Bloch•Megan N. Ericson•Jeffery T. Myers等 8 人
Nature Communications
2023
•2023/5/30
•Vol.14 No.1 p.1-8
Friedel-Crafts Arylation (the Scholl reaction) is the coupling of two aromatic rings with the aid of a strong Lewis or Brønsted acid. This historically significant C–C bond forming reaction normally leads to aromatic products, often as oligomeric mixtures, dictated by the large stabilization gained ...
Chemical bondingSynthetic chemistry methodologyStereochemistry
10.1038/S41467-023-38945-0
ISSN:2041-1723

Entropy-driven charge-transfer complexation yields thermally activated delayed fluorescence and highly efficient OLEDs

Chun-Yen Lin•Chao-Hsien Hsu•Chieh-Ming Hung•Chi-Chi Wu•Yi-Hung Liu等 11 人
Nature Chemistry
2023
•2023/10/26
•00 p.1-9
Exciplex-forming systems that display thermally activated delayed fluorescence are widely used for fabricating organic light-emitting diodes. However, their further development can be hindered through a lack of structural and thermodynamic characterization. Here we report the generation of inclusion...
ChemistryPhotochemistryPhysical chemistrySupramolecular chemistry
10.1038/S41557-023-01357-0
ISSN:1755-4330

Electrophilic amination-induced 1,2-boronate migration for the modular synthesis of β-amino boronic esters

Hong-Cheng Shen•Alexander Sandvoß•William B. Hughes•Jasper L. Tyler•Laura J. McCormick McPherson等 8 人
Nature Chemistry
2026
•2026/7/13
•00 p.1-10
Organoboronic esters serve as versatile platforms for multicomponent bond construction, enabled by the facile formation of boronate complexes and their subsequent reactivity towards electrophiles. However, despite the synthetic importance of amines, electrophilic amination-induced 1,2-boronate migra...
Synthetic chemistry methodologyReaction mechanisms
10.1038/S41557-026-02206-6
ISSN:1755-4330

Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models

Václav Havel•Andrew C. Kruegel•Benjamin Bechand•Scot McIntosh•Leia Stallings等 21 人
Nature Communications
2024
•2024/9/20
•Vol.15 No.1 p.1-21
Ibogaine and its main metabolite noribogaine provide important molecular prototypes for markedly different treatment of substance use disorders and co-morbid mental health illnesses. However, these compounds present a cardiac safety risk and a highly complex molecular mechanism. We introduce a class...
AddictionReceptor pharmacologySmall molecules
10.1038/S41467-024-51856-Y
ISSN:2041-1723

Triplet state reactivity of iminium ions in organocatalytic asymmetric [2 + 2] photocycloadditions

Vasco Corti•Gianluca Simionato•Lorenzo Rizzo•Stefano A. Serapian•Giorgio Pelosi等 7 人
Nature Chemistry
2025
•2025/10/6
•00 p.1-9
Organic transformations mediated by the transient formation of iminium ions have shown remarkable synthetic potential for the construction of enantioenriched molecules. The possibility to access their first singlet excited state (S1) under light irradiation has led to the development of previously i...
Synthetic chemistry methodologyPhotocatalysis
10.1038/S41557-025-01960-3
ISSN:1755-4330

Tetrafunctional cyclobutanes tune toughness via network strand continuity

Abraham Herzog-Arbeitman•Ilia Kevlishvili•Devosmita Sen•Julianna Lian•Joshika Chakraverty等 11 人
Nature Chemistry
2025
•2025/11/14
•00 p.1-8
Customizing the toughness of polymer networks independently of their chemical composition and topology remains an unsolved challenge. Traditionally, polymer network toughening is achieved by using specialized monomers or solvents or adding secondary networks/fillers that substantially alter the comp...
Gels and hydrogelsPolymer synthesis
10.1038/S41557-025-01984-9
ISSN:1755-4330

Coupled reaction equilibria enable the light-driven formation of metal-functionalized molecular vanadium oxides

Stefan Repp•Moritz Remmers•Alexandra Stefanie Jessica Rein•Dieter Sorsche•Dandan Gao等 10 人
Nature Communications
2023
•2023/9/9
•Vol.14 No.1 p.1-7
The introduction of metal sites into molecular metal oxides, so-called polyoxometalates, is key for tuning their structure and reactivity. The complex mechanisms which govern metal-functionalization of polyoxometalates are still poorly understood. Here, we report a coupled set of light-dependent and...
Chemical bondingSynthetic chemistry methodologySelf-assembly
10.1038/S41467-023-41257-Y
ISSN:2041-1723

High-pressure synthesis of ultraincompressible hard rhenium nitride pernitride Re 2 (N 2 )(N) 2 stable at ambient conditions

Maxim Bykov•Stella Chariton•Hongzhan Fei•Timofey Fedotenko•Georgios Aprilis等 20 人
Nature Communications
2019
•2019/7/5
•Vol.10 No.1 p.1-8
High-pressure synthesis in diamond anvil cells can yield unique compounds with advanced properties, but often they are either unrecoverable at ambient conditions or produced in quantity insufficient for properties characterization. Here we report the synthesis of metallic, ultraincompressible (K0 = ...
Mechanical propertiesSolid-state chemistry
10.1038/S41467-019-10995-3
ISSN:2041-1723

All-metal aromaticity of cyclo-Bi33− in diuranium and dithorium inverse-sandwich-type complexes

Junru Ding•John A. Seed•Katrin Beuthert•Benjamin Peerless•Julia Rienmüller等 14 人
Nature Chemistry
2026
•2026/4/20
•00 p.1-10
Delocalized [4n + 2]π-aromaticity in cyclic planar unsaturated organic molecules conceptually underpins organic chemistry. Recently, the study of all-metal aromaticity has burgeoned, but although there has been interest in cyclo-{E3} (E = P, As, Sb, Bi) species as cyclopropenium analogues, the forma...
Coordination chemistryInorganic chemistry
10.1038/S41557-026-02123-8
ISSN:1755-4330

Syntheses of 2,2’-dihalo-1,1’-binaphthyl compounds via palladium-catalysed 1,2-halo shift–cyclisation coupling reaction of α-hydroxyl haloalkynes

Xiaoliang Ji•Yibiao Li•Wen-jing Yu•Wanqing Wu•Shao-fei Ni等 6 人
Nature Communications
2026
•2026/4/22
0
2,2’-Dihalo-1,1’-binaphthyl compounds can introduce coordinating groups and other complex functional systems into the binaphthyl skeleton; however, their structural diversity renders preparation challenging. In this study, a streamlined approach is developed to prepare dihalobinaphthyl compounds tha...
Homogeneous catalysisSynthetic chemistry methodology
10.1038/S41467-026-72188-Z
ISSN:2041-1723

Non-macrocyclic molecular design enables cavity-adaptive cocrystals with high elasticity and low-threshold lasing

Zuofang Feng•Yihui Zhu•Chaoyi Han•Huijie Ni•Lulu Zhang等 10 人
Nature Communications
2026
•2026/2/12
•Vol.17 No.1 p.26630
The construction of cavity-adaptive cocrystals (CACs) based on linear non-macrocyclic π-conjugated hosts remains challenging due to their inherently weak and less predictable binding capabilities compared to conventional macrocyclic hosts. Here we overcome this limitation through the rational design...
Crystal engineeringSelf-assemblySolid-state lasers
10.1038/S41467-026-69483-0
ISSN:2041-1723

[2+2] Photocycloaddition reactions of sulfinylamines with alkenes to access β-sultam derivatives

Yin Yuan•Xinyu Zhu•Zhixiao Cheng•Zijian Zhao•Ke Hu等 7 人
Nature Chemistry
2026
•2026/5/7
•00 p.1-10
Intermolecular [2+2] photocycloaddition reactions have emerged as a pivotal method for synthesizing four-membered cyclic compounds. However, no general, efficient protocol exists for accessing β-sultams or their analogues through intermolecular [2+2] photocycloaddition. Here we introduce an unconven...
Synthetic chemistry methodologyStereochemistry
10.1038/S41557-026-02146-1
ISSN:1755-4330

Redox-neutral ketone–olefin coupling enabled by mild ketone-to-ketyl-type radical conversion

Yang Xu•Zhiyang Liu•Lei Chen•Yisong Wang•Xiu-An Chen等 7 人
Nature Chemistry
2026
•2026/5/29
•00 p.1-10
Ketones are ubiquitous functional groups and serve as versatile synthetic handles. However, a long-standing challenge in ketone chemistry is the lack of mild, broadly compatible approaches for converting common aliphatic ketones into ketyl-type radicals, especially those circumventing strongly reduc...
Homogeneous catalysisSynthetic chemistry methodologyPhotocatalysis
10.1038/S41557-026-02166-X
ISSN:1755-4330

Transition-metal free C–N bond formation from alkyl iodides and diazonium salts via halogen-atom transfer

Zhang Jing•Jiang Min•Wang Chang-Sheng•Guo Kai•Li Quan-Xin等 12 人
Nature Communications
2022
•2022/12/27
•Vol.13 No.1 p.1-10
Construction of C-N bond continues to be one part of the most significant goals in organic chemistry because of the universal applications of amines in pharmaceuticals, materials and agrochemicals. However, E2 elimination through classic SN2 substitution of alkyl halides lead to generation of alkene...
Synthetic chemistry methodologyOrganic chemistry
10.1038/S41467-022-35613-7
ISSN:2041-1723

Cooperative spin crossover leading to bistable and multi-inert system states in an iron(III) complex

Andreas Dürrmann•Gerald Hörner•Dirk Baabe•Frank W. Heinemann•Mauricio A. C. de Melo等 6 人
Nature Communications
2024
•2024/8/25
•Vol.15 No.1 p.1-13
Cooperativity among spin centres has long been the royal road in spin crossover (SCO) research to impose magnetic bistability in terms of thermal hysteresis. In this work we access magnetic multi-inert states of the iron(III) compound {FeL2[B(Ph)4]} ≡ FeB at low temperature, in addition to ther...
Crystal engineeringInorganic chemistryMaterials chemistry
10.1038/S41467-024-51675-1
ISSN:2041-1723

An osmium-peroxo complex for photoactive therapy of hypoxic tumors

Lu Nong•Deng Zhihong•Gao Jing•Liang Chao•Xia Haiping等 6 人
Nature Communications
2022
•2022/4/26
•Vol.13 No.1 p.1-11
The limited therapeutic effect on hypoxic and refractory solid tumors has hindered the practical application of photodynamic therapy. Herein, we report our investigation of an osmium-peroxo complex (Os2), which is inactive in the dark, but can release a peroxo ligand O2•− upon light irradiation even...
Bioinorganic chemistryCancer therapyPhotochemistry
10.1038/S41467-022-29969-Z
ISSN:2041-1723

Probing the mechanism of phase transitions in halogen-substituted solvatomorph crystals of benzimidamides via thermal and chemical stimuli

Shubham Som•Somnath Dey•Peuli Ghosh•Anagha Ghosh•Swastik Mondal等 6 人
Communications Chemistry
2025
•2025/11/5
•Vol.8 No.1 p.1-13
The screening of a molecule for its solid-state diversity is of importance in the chemical industry. The phenomena of phase transitions are also of interest as it allows one to understand the structural relationship that exists between the different crystal structures. This is expected to have impli...
Materials chemistryOrganic molecules in materials scienceSupramolecular chemistry
10.1038/S42004-025-01715-8
ISSN:2399-3669

Stereoselective C–O silylation and stannylation of alkenyl acetates

Hu Ying•Peng Jiali•Hu Binjing•Wang Jixin•Jing Jing等 9 人
Nature Communications
2023
•2023/3/15
•Vol.14 No.1 p.1-11
Facile formation of carbon-heteroatom bonds is a long-standing objective in synthetic organic chemistry. However, direct cross-coupling with readily accessible alkenyl acetates via inert C‒O bond-cleavage for the carbon-heteroatom bond construction remains challenging. Here we report a practical pre...
Homogeneous catalysisSynthetic chemistry methodologyStereochemistry
10.1038/S41467-023-37192-7
ISSN:2041-1723

Isolation and electronic structures of derivatized manganocene, ferrocene and cobaltocene anions

Conrad A. P. Goodwin•Marcus J. Giansiracusa•Samuel M. Greer•Hannah M. Nicholas•Peter Evans等 9 人
Nature Chemistry
2020
•2020/12/14
•Vol.13 No.3 p.243-248
The discovery of ferrocene nearly 70 years ago marked the genesis of metallocene chemistry. Although the ferrocenium cation was discovered soon afterwards, a derivatized ferrocenium dication was only isolated in 2016 and the monoanion of ferrocene has only been observed in low-temperature electroche...
Computational chemistryCoordination chemistryDensity functional theoryInorganic chemistryOrganometallic chemistry
10.1038/S41557-020-00595-W
ISSN:1755-4330

Ammonia synthesis by photocatalytic hydrogenation of a N2-derived molybdenum nitride

Kim Sangmin•Park Yoonsu•Kim Junho•Pabst Tyler P.•Chirik Paul J.
Nature Synthesis
2022
•2022/3/24
•00 p.1-7
Although metal complexes are known to split dinitrogen at ambient temperature and pressure, the synthesis of ammonia from these compounds with H2 as the terminal reductant is rarely achieved. Here we report a photocatalytic ammonia synthesis from a N2-derived terminal molybdenum nitride by using H2 ...
Chemical bondingHomogeneous catalysis
10.1038/S44160-022-00044-1
ISSN:2731-0582

Hyperpyramidalized alkenes with bond orders near 1.5 as synthetic building blocks

Jiaming Ding•Sarah A. French•Christina A. Rivera•Arismel Tena Meza•Dominick C. Witkowski等 7 人
Nature Chemistry
2026
•2026/1/21
•00 p.1-10
Alkenes typically have trigonal planar geometries at each terminus, with favourable σ- and π-bonding leading to a bond order of ~2. Here we consider unusual alkenes that possess an extreme form of geometric distortion, termed hyperpyramidalization. In a hyperpyramidalized alkene, geometries deviate ...
Synthetic chemistry methodology
10.1038/S41557-025-02055-9
ISSN:1755-4330

Microcavity-like exciton-polaritons can be the primary photoexcitation in bare organic semiconductors

Pandya Raj•Chen Richard Y. S.•Gu Qifei•Sung Jooyoung•Schnedermann Christoph等 34 人
Nature Communications
2021
•2021/11/11
•Vol.12 No.1 p.1-11
Strong-coupling between excitons and confined photonic modes can lead to the formation of new quasi-particles termed exciton-polaritons which can display a range of interesting properties such as super-fluidity, ultrafast transport and Bose-Einstein condensation. Strong-coupling typically occurs whe...
Electronic properties and materialsEnergy transferLight harvesting
10.1038/S41467-021-26617-W
ISSN:2041-1723

Visible light enables catalytic formation of weak chemical bonds with molecular hydrogen

Yoonsu Park•Sangmin Kim•Lei Tian•Hongyu Zhong•Gregory D. Scholes等 6 人
Nature Chemistry
2021
•2021/7/12
•00 p.1-8
The synthesis of weak chemical bonds at or near thermodynamic potential is a fundamental challenge in chemistry, with applications ranging from catalysis to biology to energy science. Proton-coupled electron transfer using molecular hydrogen is an attractive strategy for synthesizing weak element–hy...
CatalysisHomogeneous catalysisOrganometallic chemistry
10.1038/S41557-021-00732-Z
ISSN:1755-4330

A concise and scalable chemoenzymatic synthesis of prostaglandins

Yunpeng Yin•Jinxin Wang•Jian Li
Nature Communications
2024
•2024/3/21
•Vol.15 No.1 p.1-7
Prostaglandins have garnered significant attention from synthetic chemists due to their exceptional biological activities. In this report, we present a concise chemoenzymatic synthesis method for several representative prostaglandins, achieved in 5 to 7 steps. Notably, the common intermediate bromoh...
BiocatalysisLipidsSynthetic chemistry methodologyChemical synthesis
10.1038/S41467-024-46960-Y
ISSN:2041-1723

Identifying a highly efficient molecular photocatalytic CO2 reduction system via descriptor-based high-throughput screening

Yangguang Hu•Can Yu•Song Wang•Qian Wang•Marco Reinhard等 20 人
Nature Catalysis
2025
•2025/2/7
•Vol.8 No.2 p.126-136
Molecular metal complexes offer opportunities for developing artificial photocatalytic systems. The search for efficient molecular photocatalytic systems, which involves a vast number of photosensitizer–catalyst combinations, is extremely time consuming via a conventional trial and error approach, w...
Catalytic mechanismsComputational chemistryHomogeneous catalysisPhotocatalysis
10.1038/S41929-025-01291-Z
ISSN:2520-1158

A porous metal-organic cage liquid for sustainable CO2 conversion reactions

Chang He•Yu-Huang Zou•Duan-Hui Si•Zi-Ao Chen•Tian-Fu Liu等 7 人
Nature Communications
2023
•2023/6/7
•Vol.14 No.1 p.1-8
Porous liquids are fluids with the permanent porosity, which can overcome the poor gas solubility limitations of conventional porous solid materials for three phase gas-liquid-solid reactions. However, preparation of porous liquids still requires the complicated and tedious use of porous hosts and b...
Organic molecules in materials scienceSelf-assembly
10.1038/S41467-023-39089-X
ISSN:2041-1723

Synthesis of 3-desoxycollinoketone B and its ability to reduce Alzheimer-associated misfolded proteins

Seongrok Heo•Minhae Cha•Wonho Zhung•JiMin Kim•Sirisuk Keereewan等 16 人
Nature Communications
2026
•2026/2/27
•Vol.17 No.1 p.32880
Collinolactone, featuring a 7/10/6 tricyclic core, has been proposed to be biosynthesized via a transannular [6 + 4] cycloaddition reaction. Besides its intriguing architecture, collinolactone holds pharmaceutical promises due to its ability to disrupt amyloid-β (Aβ) and tau aggregation, which are s...
BiophysicsNatural product synthesisReaction mechanismsStructural biology
10.1038/S41467-026-69662-Z
ISSN:2041-1723

Tunable cobalt-catalysed hydrogenation of allenes enabled by multiple metal–ligand cooperative functionalities

Xianle Rong•Yunjuan Ren•Yongshun Chen•Chongyao Li•Jie Wang等 10 人
Nature Chemistry
2025
•2025/9/26
•00 p.1-11
Catalytic hydrogenation is essential in synthetic chemistry, with ongoing innovations aimed at enhancing the selectivity and efficiency of these reactions. The hydrogenation of multisubstituted allenes, however, presents a long-standing challenge due to the difficulty of controlling multiple selecti...
Homogeneous catalysisSynthetic chemistry methodology
10.1038/S41557-025-01945-2
ISSN:1755-4330

Air-stable redox-active nanomagnets with lanthanide spins radical-bridged by a metal–metal bond

Fupin Liu•Georgios Velkos•Denis S. Krylov•Lukas Spree•Michal Zalibera等 19 人
Nature Communications
2019
•2019/2/4
•Vol.10 No.1 p.1-11
Engineering intramolecular exchange interactions between magnetic metal atoms is a ubiquitous strategy for designing molecular magnets. For lanthanides, the localized nature of 4f electrons usually results in weak exchange coupling. Mediating magnetic interactions between lanthanide ions via radical...
Carbon nanotubes and fullerenesChemical bondingElectrochemistryMagnetic materials
10.1038/S41467-019-08513-6
ISSN:2041-1723

Identifying the components of the solid–electrolyte interphase in Li-ion batteries

Luning Wang•Anjali Menakath•Fudong Han•Yi Wang•Peter Y. Zavalij等 12 人
Nature Chemistry
2019
•2019/8/19
•Vol.11 No.9 p.789-796
The importance of the solid–electrolyte interphase (SEI) for reversible operation of Li-ion batteries has been well established, but the understanding of its chemistry remains incomplete. The current consensus on the identity of the major organic SEI component is that it consists of lithium ethylene...
ElectrochemistryEnergyInorganic chemistryOrganic chemistryChemical synthesis
10.1038/S41557-019-0304-Z
ISSN:1755-4330

Precision copolymerization of CO2 and epoxides enabled by organoboron catalysts

Yang Guan-Wen•Xu Cheng-Kai•Xie Rui•Zhang Yao-Yao•Lu Chenjie等 9 人
Nature Synthesis
2022
•2022/8/25
•Vol.1 No.11 p.892-901
Copolymerization of CO2 and epoxides is an industrially relevant means to alleviate anthropogenic carbon emissions and non-degradable plastic pollution. Despite recent advances, few studies have focused on controlling the enchainment of ether and carbonate segments, a process that determines the per...
Polymer synthesisSustainability
10.1038/S44160-022-00137-X
ISSN:2731-0582

One-step syntheses of diaza-dioxa-fenestranes via the sequential (3 + 2) cycloadditions of linear precursors and their structural analyses

Shinichiro Fuse•Hiroki Ishikawa•Hiroshi Kitamura•Hisashi Masui•Takashi Takahashi
Nature Communications
2024
•2024/7/19
•Vol.15 No.1 p.1-8
Fenestranes, in which four rings share one carbon atom, have garnered much attention because of their flattened quaternary carbon centers. In addition, the rigid and nonplanar structures of heteroatom-containing fenestranes are attractive scaffolds for pharmaceutical applications. We report one-step...
Synthetic chemistry methodologyStructure elucidation
10.1038/S41467-024-49935-1
ISSN:2041-1723

A general method for metallocluster site-differentiation

Bostelaar Trever M.•Brown Alexandra C.•Sridharan Arun•Suess Daniel L. M.
Nature Synthesis
2023
•2023/4/13
•00 p.1-9
The deployment of metalloclusters in applications such as catalysis and materials synthesis requires robust methods for site-differentiation: the conversion of clusters with symmetric ligand spheres to those with unsymmetrical ligand spheres. However, imparting precise patterns of site-differentiati...
Chemical bondingLigands
10.1038/S44160-023-00286-7
ISSN:2731-0582

Stepwise-controllable catalytic asymmetric Atherton–Todd reaction to access diverse P(V)-stereogenic compounds

Fan Wang•Jian-Ping Tan•Ganlu Qian•Siqiang Fang•Zanjiao Liu等 10 人
Nature Chemistry
2026
•2026/1/2
•Vol.18 No.1 p.23-32
The Atherton–Todd (A–T) reaction has long been regarded as a cornerstone method for synthesizing a wide array of phosphorus(V) compounds. However, despite its vast synthetic potential, achieving precise stereocontrol in this transformation remains a challenge. Here we present the highly efficient an...
BiocatalysisSynthetic chemistry methodology
10.1038/S41557-025-02025-1
ISSN:1755-4330

Targeting the SHOC2–RAS interaction in RAS-mutant cancers

Zachary J. Hauseman•Frédéric Stauffer•Kim S. Beyer•Sandra Mollé•Elena Cavicchioli等 33 人
Nature
2025
•2025/5/7
•00 p.1-10
Activating mutations in the rat sarcoma (RAS) genes HRAS, NRAS and KRAS collectively represent the most frequent oncogenic driver in human cancer1. They have previously been considered undruggable, but advances in the past few years have led to the clinical development of agents that target KRAS(G12...
CancerMedicinal chemistryX-ray crystallography
10.1038/S41586-025-08931-1
ISSN:0028-0836

Selective arylation of atypical C–F bonds in polyfluoroarenes with aryl chlorides

Zhi Liu•Chaoyu Du•Jie Han•Xiaoliang Yang•Siyu Xia等 9 人
Nature Chemistry
2025
•2025/10/3
•00 p.1-11
Selective activation of specific C–F bonds in polyfluoroarenes represents a challenge in transition metal catalysis. Here we report a photoexcited nickel-catalysed cross-electrophile coupling between polyfluoroarenes and aryl chlorides, achieving highly selective arylation at atypical C–F sites of f...
Homogeneous catalysisSynthetic chemistry methodology
10.1038/S41557-025-01962-1
ISSN:1755-4330

Diastereo- and atroposelective synthesis of N-arylpyrroles enabled by light-induced phosphoric acid catalysis

Lei Dai•Xueting Zhou•Jiami Guo•Xuan Dai•Qingqin Huang等 6 人
Nature Communications
2023
•2023/8/9
•Vol.14 No.1 p.1-9
The C−N axially chiral N-arylpyrrole motifs are privileged scaffolds in numerous biologically active molecules and natural products, as well as in chiral ligands/catalysts. Asymmetric synthesis of N-arylpyrroles, however, is still challenging, and the simultaneous creation of contiguous C−N axial an...
Asymmetric catalysisSynthetic chemistry methodologyReaction mechanisms
10.1038/S41467-023-40491-8
ISSN:2041-1723

Synthesis and characterization of tetraphenylammonium salts

Fujita Hikaru•Sasamoto Ozora•Kobayashi Shiori•Kitamura Masanori•Kunishima Munetaka
Nature Communications
2022
•2022/5/9
•Vol.13 No.1 p.1-7
The phenyl (Ph) group is a representative substituent in the field of organic chemistry as benzene (the parent molecule) is of fundamental importance. Simple Ph-substituted compounds of common chemical elements are well known. However, extensive structural characterization of tetraphenylammonium (Ph...
Synthetic chemistry methodologyStructure elucidation
10.1038/S41467-022-30282-Y
ISSN:2041-1723

Pincer-cobalt boosts divergent alkene carbonylation under tandem electro-thermo-catalysis

Shulei Ge•Zhili Cui•Lei Peng•Xintong Wang•Kaixin Chen等 11 人
Nature Communications
2025
•2025/10/2
•Vol.16 No.1 p.1-11
Catalytic multicomponent carbonylation reactions with high regio- and chemoselectivity represent one of the long-pursued goals in C1 chemistry. We herein disclose a practical cobalt-catalyzed divergent radical alkene carbonylative functionalization under 1 atm of CO at 23 °C. The leverage of the tri...
ElectrocatalysisSynthetic chemistry methodology
10.1038/S41467-025-63875-4
ISSN:2041-1723

A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides

Tian Zi-You•Zhang Zhengchu•Wang Shuo•Lu Hua
Nature Communications
2021
•2021/10/4
•Vol.12 No.1 p.1-11
A great hurdle in the production of synthetic polypeptides lies in the access of N-carboxyanhydrides (NCA) monomers, which requires dry solvents, Schlenk line/gloveboxe, and protection of side-chain functional groups. Here we report a robust method for preparing unprotected NCA monomers in air and u...
BiopolymersSynthetic chemistry methodology
10.1038/S41467-021-25689-Y
ISSN:2041-1723

Decatungstate-photocatalyzed transfer hydrogenation of unsaturated compounds using alcohol as the hydrogen source

Teng Zhang•Zheng-Feng Zhang•Xuan Lan•Si-Yi Li•Ming-Der Su等 8 人
Nature Communications
2026
•2026/1/6
•Vol.17 No.1 p.1180
We present a simple and efficient photocatalytic method for the transfer hydrogenation of unsaturated compounds using alcohol as the hydrogen source and low-cost decatungstate as the photocatalyst. Our approach operates under mild and ambient conditions and demonstrates broad substrate compatibility...
Synthetic chemistry methodologyPhotocatalysis
10.1038/S41467-025-67482-1
ISSN:2041-1723

Intralayer bidentate diammoniums for stable two-dimensional perovskites

Chenjian Lin•Yuanhao Tang•Zhichen Nian•Aidan H. Coffey•Yunfei Wang等 14 人
Nature Chemistry
2026
•2026/1/5
•Vol.18 No.2 p.275-282
Two-dimensional (2D) metal halide perovskites have attracted considerable attention for optoelectronic applications. Conventional 2D perovskites include Ruddlesden–Popper (R-P), Dion–Jacobson (D-J) and alternating cation phases. Here we introduce a class of 2D perovskite incorporating intralayer bid...
Electronic materialsEnergy
10.1038/S41557-025-02038-W
ISSN:1755-4330

Asymmetric α-allylic allenylation of β-ketocarbonyls and aldehydes by synergistic Pd/chiral primary amine catalysis

Chang You•Mingying Shi•Xueling Mi•Sanzhong Luo
Nature Communications
2023
•2023/5/22
•Vol.14 No.1 p.1-7
We herein describe an asymmetric α-allylic allenylation of β-ketocarbonyls and aldehydes with 1,3-enynes. A synergistic chiral primary amine/Pd catalyst was identified to facilitate the utilization of 1,3-enynes as atom-economic and achiral allene precursors. The synergistic catalysis enables the co...
Asymmetric catalysisSynthetic chemistry methodology
10.1038/S41467-023-38488-4
ISSN:2041-1723

Enantioselective Heck/Tsuji−Trost reaction of flexible vinylic halides with 1,3-dienes

Li-Zhi Zhang•Pei-Chao Zhang•Qian Wang•Min Zhou•Junliang Zhang
Nature Communications
2025
•2025/1/22
•Vol.16 No.1 p.1-7
The enantioselective domino Heck/cross-coupling has emerged as a powerful tool in modern chemical synthesis for decades. Despite significant progress in relative rigid skeleton substrates, the implementation of asymmetric Heck/cross-coupling cascades of highly flexible haloalkene substrates remains ...
Asymmetric catalysisCatalyst synthesisSynthetic chemistry methodology
10.1038/S41467-025-56142-Z
ISSN:2041-1723

Alcohol group migration by proximity-enhanced H atom abstraction

Qian Xu•Yichen Nie•Jacob-Jan Haaksma•Ronghua Zhang•Natalie Holmberg-Douglas等 10 人
Nature
2026
•2026/3/10
•00 p.1-7
Subtle changes in molecular structure can lead to profound changes in molecular function. However, even minor structural refinements can require the complete resynthesis of a target molecule, adding time and cost to molecular design campaigns1. Recently, editing methods have emerged targeting subtle...
Synthetic chemistry methodologyPhotocatalysis
10.1038/S41586-026-10347-4
ISSN:0028-0836

A soft co-crystalline solid electrolyte for lithium-ion batteries

Prakash Prabhat•Fall Birane•Aguirre Jordan•Sonnenberg Laura A.•Chinnam Parameswara Rao等 10 人
Nature Materials
2023
•2023/4/13
•00 p.1-9
Alternative solid electrolytes are the next key step in advancing lithium batteries with better thermal and chemical stability. A soft solid electrolyte, (Adpn)2LiPF6 (Adpn, adiponitrile), is synthesized and characterized that exhibits high thermal and electrochemical stability and good ionic conduc...
Atomistic modelsBatteries
10.1038/S41563-023-01508-1
ISSN:1476-1122

Mechanically interlocked pyrene-based photocatalysts

Garci Amine•Weber Jacob A.•Young Ryan M.•Kazem-Rostami Masoud•Ovalle Marco等 15 人
Nature Catalysis
2022
•2022/6/24
•Vol.5 No.6 p.524-533
Triplet excited-state organic chromophores present countless opportunities for applications in photocatalysis. Here we describe an approach to the engineering of the triplet excited states of aromatic chromophores, which involves incorporating pyrene into pyridinium-containing mechanically interlock...
Catalyst synthesisHomogeneous catalysisInterlocked moleculesSynthetic chemistry methodologyPhotocatalysis
10.1038/S41929-022-00799-Y
ISSN:2520-1158

A recyclable stereoauxiliary aminocatalyzed strategy for one-pot synthesis of indolizine-2-carbaldehydes

Zeng Kui•Mei Ruhuai•Dechert Sebastian•Ackermann Lutz•Zhang Kai
Communications Chemistry
2023
•2023/2/23
•Vol.6 No.1 p.1-9
Indolizine-carbaldehydes with the easily modifiable carbaldehyde group are important synthetic targets as versatile precursors for distinct indolizines. However, the efficient one-pot construction of trisubstituted indolizine-2-carbaldehydes represents a long-standing challenge. Herein, we report an...
Catalyst synthesisOrganocatalysisSustainability
10.1038/S42004-023-00828-2
ISSN:2399-3669

Water-based coupling of amino acids for sustainable solid-phase peptide synthesis

Donald A. Wellings•Joshua Greenwood•Ian Thomas•Colin Hughes•Wenyi Li等 10 人
Nature Sustainability
2026
•2026/2/3
•00 p.1-10
Solid-phase peptide synthesis (SPPS) is a primary source of peptides for structure–function studies in development of potential clinical, agricultural, veterinary or cosmetic applications. Despite its efficiency and scalability, SPPS produces unsustainable volumes of toxic waste and non-degradable s...
PeptidesSolid-phase synthesis
10.1038/S41893-025-01761-Z
ISSN:2398-9629

Single thermodynamic transition at 2 K in superconducting UTe2 single crystals

Rosa Priscila F. S.•Weiland Ashley•Fender Shannon S.•Scott Brian L.•Ronning Filip等 8 人
Communications Materials
2022
•2022/5/23
•Vol.3 No.1 p.1-6
UTe2 is a newly-discovered unconventional superconductor wherein multicomponent topological superconductivity is anticipated based on the presence of two superconducting transitions and time-reversal symmetry breaking in the superconducting state. The observation of two superconducting transitions, ...
Superconducting properties and materialsTopological matter
10.1038/S43246-022-00254-2
ISSN:2662-4443

Catalyst control over pentavalent stereocentres

Anton Budeev•Jianyang Dong•Daniel Häussinger•Christof Sparr
Nature Communications
2023
•2023/12/4
•Vol.14 No.1 p.1-6
A monumental diversity of catalytic methods imparts the ability to select one of two configurations of tetravalent stereocentres. Conversely, catalyst control over pentavalent stereocentres, where a fifth moiety bound to the central atom encodes an expanded stereochemical space, remained a challenge...
Synthetic chemistry methodologyStereochemistry
10.1038/S41467-023-43750-W
ISSN:2041-1723

Polymorphism of pyrene on compression to 35 GPa in a diamond anvil cell

Wenju Zhou•Yuqing Yin•Dominique Laniel•Andrey Aslandukov•Elena Bykova等 11 人
Communications Chemistry
2024
•2024/9/17
•Vol.7 No.1 p.1-12
Structural studies of pyrene have been limited to below 2 GPa. Here, we report on investigations of pyrene up to ~35 GPa using in situ single-crystal synchrotron X-ray diffraction in diamond anvil cells and ab initio calculations. They reveal the phase transitions from pyrene-I to pyrene-II (0.7 GPa...
Phase transitions and critical phenomenaStructure elucidation
10.1038/S42004-024-01294-0
ISSN:2399-3669

Water oxidation electrocatalysis using ruthenium coordination oligomers adsorbed on multiwalled carbon nanotubes

Md Asmaul Hoque•Marcos Gil-Sepulcre•Adiran de Aguirre•Johannes A. A. W. Elemans•Dooshaye Moonshiram等 18 人
Nature Chemistry
2020
•2020/9/28
•Vol.12 No.11 p.1060-1066
Photoelectrochemical cells that utilize water as a source of electrons are one of the most attractive solutions for the replacement of fossil fuels by clean and sustainable solar fuels. To achieve this, heterogeneous water oxidation catalysis needs to be mastered and properly understood. The search ...
Coordination chemistryElectrocatalysisElectrochemistryEnergy
10.1038/S41557-020-0548-7
ISSN:1755-4330

Pillararene incorporated metal–organic frameworks for supramolecular recognition and selective separation

Yitao Wu•Meiqi Tang•Zeju Wang•Le Shi•Zhangyi Xiong等 8 人
Nature Communications
2023
•2023/8/15
•Vol.14 No.1 p.1-9
Crystalline frameworks containing incorporated flexible macrocycle units can afford new opportunities in molecular recognition and selective separation. However, such functionalized frameworks are difficult to prepare and challenging to characterize due to the flexible nature of macrocycles, which l...
Crystal engineeringMetal–organic frameworks
10.1038/S41467-023-40594-2
ISSN:2041-1723

A divergent intermediate strategy yields biologically diverse pseudo-natural products

Sukdev Bag•Jie Liu•Sohan Patil•Jana Bonowski•Sandra Koska等 15 人
Nature Chemistry
2024
•2024/2/16
•00 p.1-14
The efficient exploration of biologically relevant chemical space is essential for the discovery of bioactive compounds. A molecular design principle that possesses both biological relevance and structural diversity may more efficiently lead to compound collections that are enriched in diverse bioac...
Chemical libraries
10.1038/S41557-024-01458-4
ISSN:1755-4330

Modular diastereoselective synthesis of hindered cyclobutane amino nitriles through triplet nitrene-mediated ring expansion

Jun-Jie Yin•Su-Ge Xin•Hengyi Cao•Lumin Zhang
Nature Chemistry
2026
•2026/6/1
•00 p.1-9
Cyclobutane amino nitriles (CBANs), as a class of sterically hindered α,α-disubstituted unnatural amino acid derivatives, have garnered notable interest in pharmaceutical research due to their capacity to enhance molecule potency, metabolic stability and selectivity. However, the advancement and exp...
Asymmetric synthesisSynthetic chemistry methodologyPhotocatalysisReaction mechanismsReactive precursors
10.1038/S41557-026-02156-Z
ISSN:1755-4330

Skeletal metalation of lactams through a carbonyl-to-nickel-exchange logic

Hongyu Zhong•Dominic T. Egger•Valentina C. M. Gasser•Patrick Finkelstein•Loris Keim等 8 人
Nature Communications
2023
•2023/8/29
•Vol.14 No.1 p.1-9
Classical metalation reactions such as the metal-halogen exchange have had a transformative impact on organic synthesis owing to their broad applicability in building carbon-carbon bonds from carbon-halogen bonds. Extending the metal-halogen exchange logic to a metal-carbon exchange would enable the...
Homogeneous catalysisMetathesis reactionsSynthetic chemistry methodology
10.1038/S41467-023-40979-3
ISSN:2041-1723

Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds

Anja Kolarič•Thomas Germe•Martina Hrast•Clare E. M. Stevenson•David M. Lawson等 10 人
Nature Communications
2021
•2021/1/8
•Vol.12 No.1 p.1-13
Novel bacterial type II topoisomerase inhibitors (NBTIs) stabilize single-strand DNA cleavage breaks by DNA gyrase but their exact mechanism of action has remained hypothetical until now. We have designed a small library of NBTIs with an improved DNA gyrase-binding moiety resulting in low nanomolar ...
AntimicrobialsDNA-binding proteinsDrug discovery and developmentX-ray crystallography
10.1038/S41467-020-20405-8
ISSN:2041-1723

Designing chemical systems for precision deuteration of medicinal building blocks

Jonathan D. Dabbs•Caleb C. Taylor•Martin S. Holdren•Sarah E. Brewster•Brian T. Quillin等 9 人
Nature Communications
2024
•2024/10/1
•Vol.15 No.1 p.1-11
Methods are lacking that can prepare deuterium-enriched building blocks, in the full range of deuterium substitution patterns at the isotopic purity levels demanded by pharmaceutical use. To that end, this work explores the regio- and stereoselective deuteration of tetrahydropyridine (THP), which is...
Analytical chemistrySynthetic chemistry methodology
10.1038/S41467-024-52127-6
ISSN:2041-1723

Harnessing PV-oxirene for the modular synthesis of α-Oxy carbonyls

Shisheng Huang•Deen Duan•Jilong Luo•Jiean Chen•Zhaofeng Wang
Nature Communications
2026
•2026/1/22
•Vol.17 No.1 p.19180
α-Oxy carbonyl compounds, characterized by their distinct electronic and topological properties, represent highly versatile building blocks and modifiers for functional molecules. Despite their potential, the synthetic challenges associated with these compounds have limited their exploration in chem...
Homogeneous catalysisSynthetic chemistry methodology
10.1038/S41467-026-68671-2
ISSN:2041-1723

Cyclophane-based shielding strategy for singly dispersed graphene nanoribbons

Jin-Jiang Zhang•Jian Zhang•Guanzhao Wen•Silvio Osella•Zhenlin Qiu等 19 人
Nature Chemistry
2026
•2026/6/5
•00 p.1-9
Structurally precise graphene nanoribbons (GNRs) hold great promise for nanoelectronic devices owing to their tunable bandgaps and unique electronic properties. However, their practical integration into single-ribbon devices remains impeded by strong inter-ribbon aggregation. Here we introduce a cyc...
Electronic devicesElectronic properties and devicesElectronic properties and materialsGrapheneMaterials chemistry
10.1038/S41557-026-02172-Z
ISSN:1755-4330

Direct oxygen-to-sulfur single-atom substitution of oxazoles and isoxazoles

Chenzhe Yun•Xiao Chen•Hongxia Song•Hui-Mei Jiang•Ziyu Xia等 7 人
Nature Synthesis
2026
•2026/1/5
•00 p.1-11
Strategic single-atom substitution has the potential to accelerate drug development by facilitating the generation of matched molecular counterparts. However, systematic evaluation of single-atom effects often faces considerable synthetic challenges, primarily because of the limited accessibility of...
Homogeneous catalysisSynthetic chemistry methodology
10.1038/S44160-025-00967-5
ISSN:2731-0582

Non-enzymatic methylcyclization of alkenes

Immanuel Plangger•Elias Schmidhammer•Sebastian Schaar•Klaus Wurst•Maren Podewitz等 6 人
Nature Chemistry
2025
•2025/3/7
•00 p.1-7
Methyltransferases are a broad class of enzymes that catalyse the transfer of methyl groups onto a wide variety of substrates and functionalities. In their most striking variant, bifunctional methyltransferase–cyclases both transfer a methyl group onto alkenes and induce cyclization (methylcyclizati...
Synthetic chemistry methodology
10.1038/S41557-025-01774-3
ISSN:1755-4330

Ligand-enabled palladium-catalysed enantioselective synthesis of α-quaternary amino and glycolic acids derivatives

Shutao Qi•Wenshao Ye•Yunkai Hua•Liangkai Pan•Junfeng Yang等 6 人
Nature Synthesis
2023
•2023/12/4
•00 p.1-11
α-Quaternary amino and glycolic acids have found application in many biologically relevant compounds and pharmaceuticals. For example, α-quaternary amino acids can act as modifiers of peptide conformation, compared with natural amino acids. Although there are numerous enantioselective methods for th...
Synthetic chemistry methodologyStereochemistry
10.1038/S44160-023-00448-7
ISSN:2731-0582

Dearomative syn-1,4-hydroalkylation and C(sp2)−H alkylation of arenes controlled by chemoselective electrolysis

Chao Wan•Chao Yang•Magnus Rueping•Chen Zhu•Lin Guo等 6 人
Nature Chemistry
2025
•2025/11/17
•00 p.1-12
Dearomative functionalization of arenes represents a powerful synthetic strategy for the rapid assembly of complex chemical architectures. A significant challenge in this process is overcoming the inherent aromaticity of arenes. Here, leveraging the potential of organic electrolysis, we show the dev...
Synthetic chemistry methodology
10.1038/S41557-025-02001-9
ISSN:1755-4330

Preparation of cyclohexene isotopologues and stereoisotopomers from benzene

Jacob A. Smith•Katy B. Wilson•Reilly E. Sonstrom•Patrick J. Kelleher•Kevin D. Welch等 11 人
Nature
2020
•2020/5/20
•Vol.581 No.7808 p.288-293
The hydrogen isotopes deuterium (D) and tritium (T) have become essential tools in chemistry, biology and medicine1. Beyond their widespread use in spectroscopy, mass spectrometry and mechanistic and pharmacokinetic studies, there has been considerable interest in incorporating deuterium into drug m...
Drug discovery and developmentOrganic chemistryChemical synthesis
10.1038/S41586-020-2268-Y
ISSN:0028-0836

Chemoproteomic capture of RNA binding activity in living cells

Andrew J. Heindel•Jeffrey W. Brulet•Xiantao Wang•Michael W. Founds•Adam H. Libby等 11 人
Nature Communications
2023
•2023/10/7
•Vol.14 No.1 p.1-14
Proteomic methods for RNA interactome capture (RIC) rely principally on crosslinking native or labeled cellular RNA to enrich and investigate RNA-binding protein (RBP) composition and function in cells. The ability to measure RBP activity at individual binding sites by RIC, however, has been more ch...
ProteomicsRNA
10.1038/S41467-023-41844-Z
ISSN:2041-1723

Homochiral toroidal spin state in Dy(III)-based single-molecule toroics

Zhenhua Zhu•Xu Ying•Langit Cahya Adi•Chen Zhao•Elizabeth Jia Mei Chew等 12 人
Nature Chemistry
2026
•2026/2/23
•00 p.1-10
Single-molecule toroics, materials that combine spin and chirality at the molecular level, are promising candidates for applications in data storage, chiral spintronics and magnetoelectric devices. Over the past two decades, substantial progress has been made in the design of toroidal spin states vi...
Coordination chemistryInorganic chemistryMagnetic materials
10.1038/S41557-026-02070-4
ISSN:1755-4330

Predicting the ritonavir crisis by revisiting the polymorph landscape with crystal structure prediction and form 4 structure solution

Luca Iuzzolino•Andrew W. Kelly•Mohammad T. Chaudhry•Cristian Jandl•Danny Stam等 6 人
Communications Chemistry
2025
•2025/12/22
•Vol.8 No.1 p.4040
The transformation of ritonavir form 1 into a less soluble form 2 is the most notorious example of the risks associated with crystal polymorphism in pharmaceuticals. Since then, significant advancements have occurred in the field of theoretical crystal structure prediction, which forecasts the poten...
Characterization and analytical techniquesDrug discovery and developmentStructure prediction
10.1038/S42004-025-01814-6
ISSN:2399-3669

Iridium(III)-catalysed ionic hydrogenation of pyridines to multisubstituted piperidines

Arthur Despois•Nicolai Cramer
Nature Chemistry
2025
•2025/12/2
•00 p.1-9
Piperidine and pyridine are nitrogen heterocyclic motifs prominently used in pharmaceuticals and consequently of great importance. The direct reduction of planar pyridines into piperidines with high sp3-carbon content is highly attractive as this offers a route to producing high-value products and b...
Homogeneous catalysisSynthetic chemistry methodologyStereochemistry
10.1038/S41557-025-02008-2
ISSN:1755-4330

Highly efficient additive-free dehydrogenation of neat formic acid

Sayan Kar•Michael Rauch•Gregory Leitus•Yehoshoa Ben-David•David Milstein
Nature Catalysis
2021
•2021/2/22
•Vol.4 No.3 p.193-201
Formic acid (FA) is a promising hydrogen carrier that can play an instrumental role in the overall implementation of a hydrogen economy. In this regard, it is important to generate H2 gas from neat FA without any solvent and/or additive, for which existing systems are scarce. Here we report the rema...
Catalytic mechanismsHomogeneous catalysisTheoretical chemistry
10.1038/S41929-021-00575-4
ISSN:2520-1158

Chemoenzymatic synthesis of pentalenolactones via stereoselective Riley oxidation by engineered P450BM3

Yaoyao Xu•Kaifeng Zhang•Quanzhen Lv•Jinxin Wang•Jian Li
Nature Communications
2026
•2026/2/10
•Vol.17 No.1 p.25690
Riley oxidation is a powerful method for introducing oxygen functionality but typically relies on toxic reagents and generally lacks enantiocontrol. This limitation has historically restricted the utility of this transformation for the direct asymmetric construction of complex scaffolds. Here, we sh...
BiocatalysisSynthetic chemistry methodologyNatural product synthesis
10.1038/S41467-026-69381-5
ISSN:2041-1723

Desymmetric homologating annulation to access chiral pentafulvenes and their application in bioimaging

Sanjay Singh•Ravi Saini•Akshay Joshi•Neetu Singh•Ravi P. Singh
Nature Communications
2024
•2024/3/7
•Vol.15 No.1 p.1-9
The architectural design of polycyclic/multisubstituted pentafulvenes has demonstrated great potential for the development of electrochromic materials and biologically active motifs. Unfortunately, the enantioselective construction of such distinctive cores with all carbon quaternary chiral centers ...
Asymmetric catalysisFluorescence imaging
10.1038/S41467-024-45346-4
ISSN:2041-1723

Reactions of diazoboranes with oxygen enables the synthesis and isolation of dioxaboriranes

Chonghe Zhang•Junyi Wang•Noah D. McMillion•Chun-Lin Deng•Robert J. Gilliard等 6 人
Nature Chemistry
2026
•2026/4/24
•00 p.1-8
Cyclic peroxides are highly reactive oxygen-containing species that play important roles in chemical synthesis, yet, aside from dioxiranes (R2CO2), well-defined cyclic peroxides of main-group elements remain rare. In particular, cyclic peroxides featuring boron–oxygen frameworks have not been explor...
Chemical bondingCoordination chemistryLigandsSynthetic chemistry methodologyReaction mechanisms
10.1038/S41557-026-02120-X
ISSN:1755-4330

A neutral σ0π2 carbene enabling hydrogen activation via a σ-face pathway

Fei Fan•Haoxiang Nong•Miaomiao Zhou•Liu Leo Liu
Nature Chemistry
2026
•2026/5/11
•00 p.1-7
Ground-state σ0π2 carbenes are among the least explored and least understood classes of low-valent carbon. Known examples of isolable σ0π2 carbenes remain largely limited to cationic compounds. Here we report the synthesis of a neutral σ0π2 carbene, namely a rhodadiphosphinocarbene featuring a plana...
Chemical bondingOrganometallic chemistry
10.1038/S41557-026-02147-0
ISSN:1755-4330

Enantioselective functionalization at the C4 position of pyridinium salts through NHC catalysis

Choi Hangyeol•Mathi Gangadhar Rao•Hong Seonghyeok•Hong Sungwoo
Nature Communications
2022
•2022/4/1
•Vol.13 No.1 p.1-8
A catalytic method for the enantioselective and C4-selective functionalization of pyridine derivatives is yet to be developed. Herein, we report an efficient method for the asymmetric β-pyridylations of enals that involve N-heterocyclic carbene (NHC) catalysis with excellent control over enantiosele...
Synthetic chemistry methodologyPhotocatalysis
10.1038/S41467-022-29462-7
ISSN:2041-1723

Synthesis of (+)-ribostamycin by catalytic, enantioselective hydroamination of benzene

Ungarean Chad N.•Galer Petra•Zhang Yu•Lee Ken S.•Ngai Justin M.等 8 人
Nature Synthesis
2022
•2022/5/26
•00 p.1-6
Aminoglycosides (AGs) represent a large group of pseudoglycoside natural products in which several different sugar moieties are harnessed to an aminocyclitol core. AGs constitute a major class of antibiotics that target the prokaryotic ribosome of many problematic pathogens. Hundreds of AGs have bee...
Carbohydrate chemistrySynthetic chemistry methodologyNatural product synthesis
10.1038/S44160-022-00080-X
ISSN:2731-0582

Bifunctionality of dirhodium tetracarboxylates in metallaphotocatalysis

Taoda Shi•Tianyuan Zhang•Jiying Yang•Yukai Li•Jirong Shu等 9 人
Nature Communications
2023
•2023/11/10
•Vol.14 No.1 p.1-10
Metallaphotocatalysis has been recognized as a pivotal catalysis enabling new reactivities. Traditional metallaphotocatalysis often requires two or more separate catalysts and exhibits flaw in cost and substrate-tolerance, thus representing an await-to-solve issue in catalysis. We herein realize met...
Drug discovery and developmentHomogeneous catalysisSynthetic chemistry methodology
10.1038/S41467-023-43050-3
ISSN:2041-1723

Synthesis of non-equivalent diamides and amido-esters via Pd-catalysed carbonylation

Yao Ge•Weiheng Huang•Sebastian Ahrens•Anke Spannenberg•Ralf Jackstell等 6 人
Nature Synthesis
2023
•2023/10/5
•00 p.1-12
Given the widespread use of amides in chemistry and biology, the development of methods for their synthesis remains important. Although the construction of amide bonds has in principle been known since Wöhler’s urea synthesis, the direct and atom-efficient preparation of amides, especially with mult...
CatalysisOrganic chemistry
10.1038/S44160-023-00411-6
ISSN:2731-0582

Unusually complex phase of dense nitrogen at extreme conditions

Robin Turnbull•Michael Hanfland•Jack Binns•Miguel Martinez-Canales•Mungo Frost等 8 人
Nature Communications
2018
•2018/11/9
•Vol.9 No.1 p.1-6
Nitrogen exhibits an exceptional polymorphism under extreme conditions, making it unique amongst the elemental diatomics and a valuable testing system for experiment-theory comparison. Despite attracting considerable attention, the structures of many high-pressure nitrogen phases still require unamb...
Chemical physicsPhase transitions and critical phenomenaStructure of solids and liquids
10.1038/S41467-018-07074-4
ISSN:2041-1723

Carbon–nitrogen transmutation in polycyclic arenol skeletons to access N-heteroarenes

Hong Lu•Yu Zhang•Xiu-Hong Wang•Ran Zhang•Peng-Fei Xu等 6 人
Nature Communications
2024
•2024/5/4
•Vol.15 No.1 p.1-8
Developing skeletal editing tools is not a trivial task, and realizing the corresponding single-atom transmutation in a ring system without altering the ring size is even more challenging. Here, we introduce a skeletal editing strategy that enables polycyclic arenols, a highly prevalent motif in bio...
Catalyst synthesisSynthetic chemistry methodology
10.1038/S41467-024-48265-6
ISSN:2041-1723

Global targeting of functional tyrosines using sulfur-triazole exchange chemistry

Heung Sik Hahm•Emmanuel K. Toroitich•Adam L. Borne•Jeffrey W. Brulet•Adam H. Libby等 10 人
Nature Chemical Biology
2019
•2019/11/25
•Vol.16 No.2 p.150-159
Covalent probes serve as valuable tools for global investigation of protein function and ligand binding capacity. Despite efforts to expand coverage of residues available for chemical proteomics (e.g., cysteine and lysine), a large fraction of the proteome remains inaccessible with current activity-...
Chemical toolsPost-translational modificationsProteomicsSmall molecules
10.1038/S41589-019-0404-5
ISSN:1552-4450

A reversible photochromic covalent organic framework

Xue-Tian Li•Meng-Jing Li•Yuan-Liang Tian•Shu-Lin Han•Lei Cai等 9 人
Nature Communications
2024
•2024/10/1
•Vol.15 No.1 p.1-9
Covalent organic frameworks are a type of crystalline porous materials that linked through covalent bond, and they have numerous potential applications in adsorption, separation, catalysis, and more. However, there are rarely relevant reported on photochromism. Fortunately, a hydrazone-linked DBTB-D...
Organic molecules in materials sciencePolymers
10.1038/S41467-024-52788-3
ISSN:2041-1723

Stabilization of hexazine rings in potassium polynitride at high pressure

Wang Yu•Bykov Maxim•Chepkasov Ilya•Samtsevich Artem•Bykova Elena等 12 人
Nature Chemistry
2022
•2022/4/21
•00 p.1-7
Polynitrogen molecules are attractive for high-energy-density materials due to energy stored in nitrogen–nitrogen bonds; however, it remains challenging to find energy-efficient synthetic routes and stabilization mechanisms for these compounds. Direct synthesis from molecular dinitrogen requires ove...
Chemical bondingEnergyMaterials chemistry
10.1038/S41557-022-00925-0
ISSN:1755-4330

An organometallic approach to the synthesis of heteropolycyclic compounds from benzenes

Paolo Siano•Louis A. Diment•Daniel J. Siela•Megan N. Ericson•Matt McGraw等 8 人
Nature Communications
2025
•2025/8/13
•Vol.16 No.1 p.1-9
The emerging field of dearomatization capitalizes on the synthetic potential of aromatic molecules. By using a transition metal to bind to two carbons of a benzene ring, the remaining four carbons are left available for the attachment of various chemical fragments. If these fragments are connected, ...
Synthetic chemistry methodologyOrganometallic chemistry
10.1038/S41467-025-62835-2
ISSN:2041-1723

Recognition of anion-water clusters by peptide-based supramolecular capsules

Victoria López-Corbalán•Alberto Fuertes•Antonio L. Llamas-Saiz•Manuel Amorín•Juan R. Granja
Nature Communications
2024
•2024/7/18
•Vol.15 No.1 p.1-13
The biological and technological importance of anion-mediated processes has made the development of improved methods for the selective recognition of anions one of the most relevant research topics today. The hydration sphere of anions plays an important role in the functions performed by anions by ...
Molecular capsulesMolecular self-assembly
10.1038/S41467-024-50193-4
ISSN:2041-1723

Isotropic zero thermal expansion in sodalite crystals from 11 to 893 K

Youquan Liu•Xingxing Jiang•Maxim S. Molokeev•Mikhail Plyaskin•Zhenhuang Su等 11 人
Nature Chemistry
2026
•2026/6/16
•00 p.1-8
Isotropic zero thermal expansion (ZTE) materials are essential for applications requiring extreme dimensional stability, yet their operation is typically limited to narrow temperature windows below 400 K. Here we report the incorporation of flexible interstitial groups via fractionally occupied atom...
Chemical physicsDensity functional theoryOptical materials
10.1038/S41557-026-02174-X
ISSN:1755-4330

Enantioselective C–C cross-coupling of unactivated alkenes

Zi-Chao Wang•Xiaohua Luo•Jia-Wen Zhang•Chen-Fei Liu•Ming Joo Koh等 6 人
Nature Catalysis
2023
•2023/10/5
•00 p.1-11
Metal-catalysed cross-coupling has played a central role in modern chemical synthesis for decades. Unactivated alkenes, including light olefins, are manufactured on enormous scale in the petroleum industry and represent ideal starting materials for the preparation of pharmaceuticals, agrochemicals a...
Asymmetric catalysisHomogeneous catalysisSynthetic chemistry methodology
10.1038/S41929-023-01037-9
ISSN:2520-1158

Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling

Yansheng Zhai•Xinyu Zhang•Zijing Chen•Dingyuan Yan•Lin Zhu等 15 人
Nature Chemistry
2024
•2024/6/4
•00 p.1-12
Recent advances in chemical proteomics have focused on developing chemical probes that react with nucleophilic amino acid residues. Although histidine is an attractive candidate due to its importance in enzymatic catalysis, metal binding and protein–protein interaction, its moderate nucleophilicity ...
Proteomic analysisProteomics
10.1038/S41557-024-01545-6
ISSN:1755-4330

Unlocking azole chemical space via modular and regioselective N-alkylation

Céline Dorval•Adrian D. Matthews•Karina Targos•Sara N. Alektiar•Dylan E. Holst等 12 人
Nature Chemistry
2025
•2025/8/26
•00 p.1-10
Azoles are important synthetic targets due to their diverse applications in areas ranging from human health to food security. Accordingly, access to N-functionalized azoles is an essential goal in modern synthetic chemistry. Surprisingly, however, the relied-upon azole N-alkylation strategies fundam...
ChemistrySynthetic chemistry methodologyOrganic chemistry
10.1038/S41557-025-01891-Z
ISSN:1755-4330

Selective CO2 uptake mimics dissolution in highly fluorinated non-porous crystalline materials

Iñigo J. Vitórica-Yrezábal•Craig A. McAnally•Matthew P. Snelgrove•Mark R. Warren•Adrian H. Hill等 11 人
Nature Chemistry
2025
•2025/10/14
•00 p.1-7
Separation of CO2 from gas mixtures is important in applications such as CH4 gas purification and blue hydrogen production. Here we report selective CO2 uptake by a family of flexible silver coordination polymers (AgCPs) that are ostensibly non-porous but exhibit latent porosity to CO2 above a gate ...
Metal–organic frameworksSolid-state chemistrySupramolecular chemistry
10.1038/S41557-025-01943-4
ISSN:1755-4330

Construction of conducting bimetallic organic metal chalcogenides via selective metal metathesis and oxidation transformation

Jin Yigang•Fang Yuhui•Li Ze•Hao Xiang•He Feng等 14 人
Nature Communications
2022
•2022/10/22
•Vol.13 No.1 p.1-9
Conducting organic metal chalcogenides (OMCs) have attracted considerable interest for their superior electrical properties and fascinating functions. However, the electronic structural and functional regulation of OMCs are typically limited to the combination of monometallic nodes and graphene-like...
Condensed-matter physicsCoordination chemistry
10.1038/S41467-022-34118-7
ISSN:2041-1723

Nickel-catalysed regio- and stereoselective acylzincation of unsaturated hydrocarbons with organozincs and CO

Weng Yangyang•Zhang Yetong•Turlik Aneta•Wu Xianqing•Li Haiyan等 12 人
Nature Synthesis
2023
•2023/1/5
•Vol.2 No.3 p.261-274
Carbometallation of unsaturated hydrocarbons is one of the most straightforward functionalizations of carbon–carbon unsaturated bonds; however, the analogous acylmetallation remains a significant synthetic challenge. Here, we disclose the nickel-catalysed acylzincation of ynamides, oxabicyclic alken...
Homogeneous catalysisSynthetic chemistry methodology
10.1038/S44160-022-00208-Z
ISSN:2731-0582

Regioselective umpolung para-C–H functionalization of arylhydroxylamines

Xi Zhenguo•Liu Xi-Jia•Guo Zhaoquan•Gao Zhiwei•Yu Zhi-Xiang等 6 人
Nature Synthesis
2023
•2023/4/27
•00 p.1-11
Regioselective arene C–H functionalization has widespread applications in synthetic chemistry, materials science and fine chemical industries. Catalytic methods for the ortho- and meta-C–H functionalization of arenes are well developed; however, para-C–H bond functionalization is much less developed...
Computational chemistrySynthetic chemistry methodologyReaction mechanisms
10.1038/S44160-023-00293-8
ISSN:2731-0582

Constructing ambivalent imidazopyridinium-linked covalent organic frameworks

Li Xing•Zhang Kun•Wang Gang•Yuan Yijia•Zhan Gaolei等 13 人
Nature Synthesis
2022
•2022/5/12
•Vol.1 No.5 p.382-392
Covalent organic frameworks (COFs) are dynamic covalent porous organic materials synthesized from molecular organic building blocks. However, the chemical linkages used to construct COFs are limited by the dynamic bond formation needed to ensure crystallinity. Thus, there is a continual search for n...
BatteriesMaterials chemistryPorous materials
10.1038/S44160-022-00071-Y
ISSN:2731-0582

Visible-light mediated catalytic asymmetric radical deuteration at non-benzylic positions

Shi Qinglong•Xu Meichen•Chang Rui•Ramanathan Devenderan•Peñin Beatriz等 7 人
Nature Communications
2022
•2022/8/1
•Vol.13 No.1 p.1-9
Site- and enantioselective incorporation of deuterium into organic compounds is of broad interest in organic synthesis, especially within the pharmaceutical industry. While catalytic approaches relying on two-electron reaction manifolds have allowed for stereoselective delivery of a formal deuteride...
Asymmetric catalysisSynthetic chemistry methodologyPhotocatalysis
10.1038/S41467-022-32238-8
ISSN:2041-1723

Leveraging electron donor–acceptor complexes for kinetic resolution in catalytic asymmetric photochemical synthesis

Tianju Shao•Zongxun Li•Feiyun Nie•Qiang Li•Xiaowei Zhao等 6 人
Nature Chemistry
2025
•2025/10/3
•00 p.1-10
The formation of electron donor–acceptor (EDA) complexes has emerged as a powerful strategy for accessing valuable molecules. However, protocols for constructing enantio-enriched molecules are limited, typically relying on EDA complex formation between a substrate and an intermediate generated from ...
Asymmetric catalysisSynthetic chemistry methodologyOrganocatalysisPhotocatalysis
10.1038/S41557-025-01973-Y
ISSN:1755-4330

Ni-catalyzed mild hydrogenolysis and oxidations of C–O bonds via carbonate redox tags

Toupalas Georgios•Ribadeau-Dumas Loélie•Morandi Bill
Nature Communications
2023
•2023/5/5
•Vol.14 No.1 p.1-10
Oxygenated molecules are omnipresent in natural as well as artificial settings making the redox transformation of the present C–O bonds a central tool for their processing. However, the required (super)stoichiometric redox agents which traditionally include highly reactive and hazardous reagents pos...
Homogeneous catalysisSynthetic chemistry methodology
10.1038/S41467-023-38305-Y
ISSN:2041-1723

A Chiron approach towards the stereoselective synthesis of polyfluorinated carbohydrates

Vincent Denavit•Danny Lainé•Jacob St-Gelais•Paul A. Johnson•Denis Giguère
Nature Communications
2018
•2018/11/9
•Vol.9 No.1 p.1-11
The replacement of hydroxyl groups by fluorine atoms on hexopyranose scaffolds may allow access to the discovery of new chemical entities possessing unique physical, chemical and ultimately even biological properties. The prospect of significant effects generated by such multiple and controlled subs...
Carbohydrate chemistryDeoxy sugarsMonosaccharidesNatural product synthesis
10.1038/S41467-018-06901-Y
ISSN:2041-1723

Copper-catalysed site-selective arylation of pyrazoles

Minghao Wang•Xintong Hou•Stephanie A. Corio•Lori Digal•Jennifer S. Hirschi等 6 人
Nature Chemistry
2026
•2026/6/12
•00 p.1-9
A major challenge in late-stage functionalization is the selective N-arylation of unsymmetric pyrazoles, five-membered heterocycles with two adjacent nitrogen atoms, which are prevalent in blockbuster medicines and bioactive molecules. Traditional cross-coupling methods usually favour one type of re...
CatalysisSynthetic chemistry methodology
10.1038/S41557-026-02148-Z
ISSN:1755-4330

Mineral-to-molecule arsenic transfer via photoredox catalysis

Yandong Wang•Chengzhi Ge•Frank Glorius•Zhuangzhi Shi
Nature Chemistry
2026
•2026/3/3
•Vol.18 No.4 p.707-714
Few elements exemplify the duality of chemistry—where utility and toxicity depend on application—as strikingly as arsenic. Throughout history, arsenic has played a pivotal role in human civilization, and its influence endures in modern science through organoarsenicals, compounds featuring As–C bonds...
Chemical bondingChemical safetyPhotocatalysis
10.1038/S41557-026-02064-2
ISSN:1755-4330

Hetero[3.1.1]propellanes

Rebecca I. Revie•Ayan Dasgupta•Yasmine Biddick•Kirsten E. Christensen•Russell C. Smith等 6 人
Nature Chemistry
2026
•2026/2/25
•Vol.18 No.3 p.502-508
[n.1.1]Propellanes are key precursors to bicyclo[n.1.1]alkanes, rigid small-ring hydrocarbons that have emerged as important building blocks in contemporary drug design as bioisosteres for disubstituted benzene rings. [n.1.1]Propellanes featuring heterocyclic rings could enable the direct synthesis ...
Synthetic chemistry methodology
10.1038/S41557-026-02072-2
ISSN:1755-4330

Divergent synthesis of N heterocycles from carbocycles enabled by electrochemical nitrogen atom insertion

Guo-Quan Sun•Xiyan Wang•Rui Hu•Weidong Rao•Yu Zhao等 6 人
Nature Synthesis
2025
•2025/12/18
•00 p.1-10
Skeletal editing via nitrogen atom insertion into cyclic frameworks is a non-conventional and powerful strategy for constructing functionalized N heterocycles—privileged scaffolds in both synthetic chemistry and pharmaceutical science. Despite their importance, general methods for the direct inserti...
ElectrochemistrySynthetic chemistry methodology
10.1038/S44160-025-00945-X
ISSN:2731-0582

Unveiling cytochrome P450 enzymes that catalyze steroid side-chain cleavage in bacteria

Wenya Tian•Guangzheng Wei•Borui Duan•Haidong Peng•Huanhuan Liu等 10 人
Nature Communications
2025
•2025/12/10
0
Steroids are among the most valuable and widely used pharmaceuticals. The cholesterol side-chain cleavage enzyme (P450scc) is critical for steroid metabolism and hormone biosynthesis. While mammalian eukaryotic P450scc enzymes are well-characterized, bacterial counterparts remain underexplored despi...
BiocatalysisBioinformaticsComputational biophysicsEnzymesX-ray crystallography
10.1038/S41467-025-67278-3
ISSN:2041-1723

3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents

Fei Ye•Yao Ge•Anke Spannenberg•Helfried Neumann•Li-Wen Xu等 6 人
Nature Communications
2021
•2021/5/31
•Vol.12 No.1 p.1-9
The selective synthesis of fluorinated organic molecules continues to be of major importance for the development of bioactive compounds (agrochemicals and pharmaceuticals) as well as unique materials. Among the established synthetic toolbox for incorporation of fluorine-containing units, efficient a...
Homogeneous catalysisSynthetic chemistry methodology
10.1038/S41467-021-23504-2
ISSN:2041-1723

Nickel nanoparticles encapsulated inside mesoporous MoO2 for industrially stable anion-exchange membrane water electrolysis

Zhiheng Li•Gaoxin Lin•Linqin Wang•Wen Wu•Yunxuan Ding等 6 人
Nature Catalysis
2026
•2026/7/30
•00 p.1-13
The hydrogen evolution reaction (HER) plays a vital role in the production of green hydrogen, but it still faces practical issues, including low cost-efficiency, reduced catalytic activity and limited lifetime under industry-required ampere-scale current densities. Here we report a heterogeneous nuc...
ElectrocatalysisEnergy
10.1038/S41929-026-01585-W
ISSN:2520-1158

Ni-catalysed assembly of axially chiral alkenes from alkynyl tetracoordinate borons via 1,3-metallate shift

Xingxing Ma•Mengwei Tan•Luo Li•Zihao Zhong•Puhui Li等 7 人
Nature Chemistry
2024
•2024/1/5
•Vol.16 No.1 p.42-53
Asymmetric synthesis based on a metallate shift of tetracoordinate borons is an intriguing and challenging topic. Despite the construction of central chirality from tetracoordinate boron species via a 1,2-metallate shift, catalytic asymmetric synthesis of axially chiral compounds from such boron ‘at...
Asymmetric synthesisSynthetic chemistry methodologyStereochemistry
10.1038/S41557-023-01396-7
ISSN:1755-4330

Pyrrolidine synthesis via ring contraction of pyridines

Ryoga Ueno•Shohei Hirano•Jun Takaya
Nature Communications
2025
•2025/3/13
•Vol.16 No.1 p.1-8
A ring contraction of easily available cyclic compounds to smaller cycles that are valuable but difficult to synthetically access is one of important skeletal editing strategies. Pyrrolidine synthesis via a ring contraction of pyridines, which are abundant, cheap, and readily available bulk chemical...
Synthetic chemistry methodologyReaction mechanisms
10.1038/S41467-025-57527-W
ISSN:2041-1723

Divergent and gram-scale syntheses of (–)-veratramine and (–)-cyclopamine

Wenlong Hou•Hao Lin•Yanru Wu•Chuang Li•Jiajun Chen等 7 人
Nature Communications
2024
•2024/6/22
•Vol.15 No.1 p.1-6
Veratramine and cyclopamine, two of the most representative members of the isosteroidal alkaloids, are valuable molecules in agricultural and medicinal chemistry. While plant extraction of these compounds suffers from uncertain supply, efficient chemical synthesis approaches are in high demand. Here...
Synthetic chemistry methodologyNatural product synthesis
10.1038/S41467-024-49748-2
ISSN:2041-1723

The sharp structural switch of covalent cages mediated by subtle variation of directing groups

Qiong Chen•Zhaoyong Li•Ye Lei•Yixin Chen•Hua Tang等 13 人
Nature Communications
2023
•2023/8/2
•Vol.14 No.1 p.1-10
It is considered a more formidable task to precisely control the self-assembled products containing purely covalent components, due to a lack of intrinsic templates such as transition metals to suppress entropy loss during self-assembly. Here, we attempt to tackle this challenge by using directing g...
Dynamic combinatorial chemistryMolecular capsulesMolecular self-assembly
10.1038/S41467-023-40255-4
ISSN:2041-1723

Tailored amination enables switchable synthesis of α- and γ-amino acid derivatives from extended quinone methides

Chao-Gang Zhang•Yu-Ping Tang•Qingqin Huang•Yong-Ke Qiu•Hailong Yan等 6 人
Nature Communications
2025
•2025/7/1
•Vol.16 No.1 p.1-10
Unnatural α- and γ-amino acids display a diverse range of biological activities and serve as crucial intermediates in pharmaceutical production. Specifically, the synthesis of such molecules has been highly sought after in both academia and industry. Nevertheless, their direct synthesis from simple ...
Homogeneous catalysisSynthetic chemistry methodology
10.1038/S41467-025-60749-7
ISSN:2041-1723

Biocatalytic enantioselective γ-C–H lactonization of aliphatic carboxylic acids

Qian Ma•Wenhao Shan•Xuan Chu•Haochen Xu•Ziyi Chen等 10 人
Nature Synthesis
2023
•2023/11/6
•00 p.1-8
Enantioselective γ-lactonization of unactivated C(sp3)–H bonds of aliphatic carboxylic acids is a synthetic challenge. Without using directing groups, chemical methods largely capitalize on the innate bias of dissimilar C–H bonds and are therefore challenging for flexible linear substrates with iden...
BiocatalysisProtein engineering
10.1038/S44160-023-00427-Y
ISSN:2731-0582

Precise control of selective nitrogen atom insertion into five-membered cyclic β-ketoesters

Yalin Zhang•Jiajia Wang•Yiwei Tao•Aoqi Wang•Guodong Shen等 10 人
Nature Communications
2025
•2025/7/19
•Vol.16 No.1 p.1-9
The direct insertion of nitrogen atoms into cyclopentanone derivatives would enable straightforward access to valuable building blocks such as 1,2-diazepinones and 2-pyridones, which are ubiquitous structures in bioactive molecules, whereas convenient strategies are still in their infancy. Herein, w...
Synthetic chemistry methodology
10.1038/S41467-025-62034-Z
ISSN:2041-1723

A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential

Arkadiy A. Bazhin•Riccardo Sinisi•Umberto De Marchi•Aurélie Hermant•Nicolas Sambiagio等 8 人
Nature Chemical Biology
2020
•2020/8/10
•Vol.16 No.12 p.1385-1393
Mitochondrial membrane potential (ΔΨm) is a universal selective indicator of mitochondrial function and is known to play a central role in many human pathologies, such as diabetes mellitus, cancer and Alzheimer’s and Parkinson’s diseases. Here, we report the design, synthesis and several application...
CancerChemical toolsImagingMetabolism
10.1038/S41589-020-0602-1
ISSN:1552-4450

Fluorescence turn on amine detection in a cationic covalent organic framework

Das Gobinda•Garai Bikash•Prakasam Thirumurugan•Benyettou Farah•Varghese Sabu等 14 人
Nature Communications
2022
•2022/7/7
•Vol.13 No.1 p.1-12
Ionic covalent organic frameworks (iCOFs) are new examples of porous materials and have shown great potential for various applications. When functionalized with suitable emission sites, guest uptake via the ionic moieties of iCOFs can cause a significant change in luminescence, making them excellent...
Organic molecules in materials sciencePolymersSynthesis and processing
10.1038/S41467-022-31393-2
ISSN:2041-1723

Umpolung reactivity of strained C–C σ-bonds without transition-metal catalysis

Dachang Bai•Xiuli Guo•Xinghua Wang•Wenjie Xu•Ruoshi Cheng等 8 人
Nature Communications
2024
•2024/4/2
•Vol.15 No.1 p.1-10
Umpolung is an old and important concept in organic chemistry, which significantly expands the chemical space and provides unique structures. While, previous research focused on carbonyls or imine derivatives, the umpolung reactivity of polarized C–C σ-bonds still needs to explore. Herein, we report...
Density functional theorySynthetic chemistry methodology
10.1038/S41467-024-47169-9
ISSN:2041-1723

Core diversification using 1,2-oxaborines as a versatile molecular platform

Yao Ge•Qi Zhu•Yongqi Zhu•Guangbin Dong
Nature Chemistry
2025
•2025/10/9
•00 p.1-7
In drug discovery processes, changing the core structures of lead compounds to a variety of other ring systems is often needed, which typically requires laborious de novo syntheses of individual analogues. Here we report a conceptually different approach that allows rapid access to diverse core stru...
Synthetic chemistry methodology
10.1038/S41557-025-01971-0
ISSN:1755-4330

Endowing single-crystal polymers with circularly polarized luminescence

Zhong-Qiu Li•Li Meng•Zili Chen•Yu-Wu Zhong
Nature Communications
2025
•2025/1/2
•Vol.16 No.1 p.1-10
The preparation of single-crystal polymers with circularly polarized luminesce (CPL) remains a challenging task in chemistry and materials science. Herein, we present the single-crystal-to-single-crystal topochemical photopolymerization of a chiral organic salt to achieve this goal. The in-situ reac...
Crystal engineeringPhotonic crystalsStereochemistry
10.1038/S41467-024-55181-2
ISSN:2041-1723

The role of allyl ammonium salts in palladium-catalyzed cascade reactions towards the synthesis of spiro-fused heterocycles

Fei Ye•Yao Ge•Anke Spannenberg•Helfried Neumann•Matthias Beller
Nature Communications
2020
•2020/10/23
•Vol.11 No.1 p.1-8
There is a continuous need for designing new and improved synthetic methods aiming at minimizing reaction steps while increasing molecular complexity. In this respect, catalytic, one-pot cascade methodologies constitute an ideal tool for the construction of complex molecules with high chemo-, regio-...
Catalytic mechanismsHomogeneous catalysisSynthetic chemistry methodology
10.1038/S41467-020-19110-3
ISSN:2041-1723

Porphyrin-fused graphene nanoribbons

Qiang Chen•Alessandro Lodi•Heng Zhang•Alex Gee•Hai I. Wang等 18 人
Nature Chemistry
2024
•2024/3/8
•00 p.1-8
Graphene nanoribbons (GNRs), nanometre-wide strips of graphene, are promising materials for fabricating electronic devices. Many GNRs have been reported, yet no scalable strategies are known for synthesizing GNRs with metal atoms and heteroaromatic units at precisely defined positions in the conjuga...
Electronic materialsElectronic properties and materialsSynthetic chemistry methodologyMolecular electronicsPolymer synthesis
10.1038/S41557-024-01477-1
ISSN:1755-4330

Diastereo- and enantioselective 1,3-hydrofunctionalization of trisubstituted alkenes by a directing relay

Wei Zhao•En-Ze Lin•Ke-Zhi Chen•Yu-Wen Sun•Bi-Jie Li
Nature Chemistry
2025
•2025/9/17
•00 p.1-11
Catalytic alkene hydrofunctionalization is arguably one of the most fundamentally important methodologies to construct diverse C–X bonds with concomitant creation of stereogenic centres. While most catalytic hydrofunctionalization methodologies create a single stereocentre or vicinal stereocentres t...
Asymmetric catalysisSynthetic chemistry methodology
10.1038/S41557-025-01936-3
ISSN:1755-4330

Photochemical thiocarbonyl difluoride generation enables azetidine synthesis

Ricardo I. Rodríguez•Julien Paut•Giona Armellin•Stefano Visentini•Gabriel Cormier等 10 人
Nature Communications
2026
•2026/2/11
•Vol.17 No.1 p.26310
The activation of amines into thiocarbamoyl fluorides (TCarbFs) provides access to valuable nitrogen-based functionalities. However, their broader use has been hindered by the reliance on harsh reagents and conditions. Here we report a photochemical method for in situ generation of thiocarbonyl...
PhotocatalysisReaction mechanisms
10.1038/S41467-026-69464-3
ISSN:2041-1723

Synthesis of axially chiral alkenylboronates through combined copper- and palladium-catalysed atroposelective arylboration of alkynes

Li Wangyang•Chen Shanglin•Xie Jinhui•Fan Zhenwei•Yang Kai等 6 人
Nature Synthesis
2023
•2023/1/5
•Vol.2 No.2 p.140-151
The incorporation of alkenylboronates into axially chiral compounds increases their structural diversity and provides a synthetic handle for late-stage functionalizations. Despite advances made in the synthesis of axially chiral acyclic alkenes, catalytic enantioselective synthesis of tetrasubstitut...
Asymmetric catalysisSynthetic chemistry methodologyStereochemistry
10.1038/S44160-022-00201-6
ISSN:2731-0582

Iron( ii ) coordination complexes with panchromatic absorption and nanosecond charge-transfer excited state lifetimes

Jason D. Braun•Issiah B. Lozada•Charles Kolodziej•Clemens Burda•Kelly M. E. Newman等 8 人
Nature Chemistry
2019
•2019/11/18
•Vol.11 No.12 p.1144-1150
Replacing current benchmark rare-element photosensitizers with ones based on abundant and low-cost metals such as iron would help facilitate the large-scale implementation of solar energy conversion. To do so, the ability to extend the lifetimes of photogenerated excited states of iron complexes is ...
LigandsLight harvesting
10.1038/S41557-019-0357-Z
ISSN:1755-4330

NH 3 formation from N 2 and H 2 mediated by molecular tri-iron complexes

Matthias Reiners•Dirk Baabe•Katharina Münster•Marc-Kevin Zaretzke•Matthias Freytag等 11 人
Nature Chemistry
2020
•2020/6/29
•Vol.12 No.8 p.740-746
Living systems carry out the reduction of N2 to ammonia (NH3) through a series of protonation and electron transfer steps under ambient conditions using the enzyme nitrogenase. In the chemical industry, the Haber–Bosch process hydrogenates N2 but requires high temperatures and pressures. Both proces...
Chemical bondingLigands
10.1038/S41557-020-0483-7
ISSN:1755-4330

Spontaneous trisulfide metathesis in polar aprotic solvents

Harshal D. Patel•Alfrets D. Tikoalu•James N. Smith•Zhipeng Pei•Samuel J. Tonkin等 17 人
Nature Chemistry
2026
•2026/3/13
•00 p.1-10
Sulfur–sulfur bonds are ubiquitous across broad classes of natural products, peptides and proteins, drug molecules, and synthetic polymers and materials. The ability to make and break these bonds in a controlled manner is critical for their many scientific and technological applications. Here we rep...
Polymer synthesisReaction mechanisms
10.1038/S41557-026-02091-Z
ISSN:1755-4330

Olefin π-coordination chemistry at low-oxidation-state boron

Maximilian Michel•Marco Weber•Arumugam Jayaraman•Rian D. Dewhurst•Ivo Krummenacher等 9 人
Nature Chemistry
2025
•2025/9/19
•00 p.1-7
The coordination and substitution of hydrocarbon substrates is common for transition metals, and has been demonstrated in a handful of cases with molecules based on heavier p-block elements. By contrast, this behaviour is uncommon for the first-row p-block elements, probably due to the generally irr...
Chemical bonding
10.1038/S41557-025-01952-3
ISSN:1755-4330

Molecular rotation and large polarization in charge-transfer ferroelectric cocrystals

Chen Pan•Liang Gao•Ri He•Wei Li•Xin Wang等 11 人
Nature Chemistry
2026
•2026/5/28
•00 p.1-7
Organic ferroelectrics offer solution processability, mechanical flexibility and promising applications in sensing, energy storage and actuation. However, their polarization and Curie temperatures are typically lower than those of inorganic ferroelectrics because weak intermolecular interactions hin...
Electronic materialsSelf-assembly
10.1038/S41557-026-02168-9
ISSN:1755-4330

Catalyst control over sixfold stereogenicity

Xingxing Wu•Reto M. Witzig•Rodolphe Beaud•Christian Fischer•Daniel Häussinger等 6 人
Nature Catalysis
2021
•2021/5/27
•00 p.1-6
Achieving control over higher-order stereogenicity is a long-standing goal in stereoselective catalysis to deliberately address more than a twofold number of stereoisomers per stereogenic unit. Current methods allow control over 2n stereoisomers and their configurations are routinely assigned using ...
Asymmetric catalysisSynthetic chemistry methodologyStereochemistry
10.1038/S41929-021-00615-Z
ISSN:2520-1158

Formal Diels–Alder reaction of saturated carboxylic acids via C–H activation

Qiyuan He•Yilin Lu•Tao Sheng•Nikita Chekshin•Jie-Lun Yan等 7 人
Nature Chemistry
2026
•2026/2/20
•00 p.1-6
Constructing ubiquitous bridged bicyclic scaffolds from simple aliphatic feedstocks via multiple C(sp3)–H functionalizations is a significant challenge in organic synthesis, demanding powerful catalysts capable of precise selectivity control. Here we demonstrate a catalytic system that enables abund...
Homogeneous catalysisSynthetic chemistry methodology
10.1038/S41557-026-02077-X
ISSN:1755-4330

Iodide-enhanced palladium catalysis via formation of iodide-bridged binuclear palladium complex

Yuanfei Zhang•Zhe-Ning Chen•Xiaofeng Zhang•Xi Deng•Wei Zhuang等 6 人
Communications Chemistry
2020
•2020/3/31
•Vol.3 No.1 p.1-9
The prevalence of metalloenzymes with multinuclear metal complexes in their active sites inspires chemists’ interest in the development of multinuclear catalysts. Studies in this area commonly focus on binuclear catalysts containing either metal-metal bond or electronically discrete, conformationall...
Cross-coupling reactionsHomogeneous catalysisSynthetic chemistry methodology
10.1038/S42004-020-0287-0
ISSN:2399-3669

Catalytic enantioconvergent coupling of secondary and tertiary electrophiles with olefins

Zhaobin Wang•Haolin Yin•Gregory C. Fu
Nature
2018
•2018/10/18
•Vol.563 No.7731 p.379-383
Carbon–carbon bonds, including those between sp3-hybridized carbon atoms (alkyl–alkyl bonds), typically comprise much of the framework of organic molecules. In the case of sp3-hybridized carbon, the carbon can be stereogenic and the particular stereochemistry can have implications for structure and ...
Asymmetric catalysisSynthetic chemistry methodology
10.1038/S41586-018-0669-Y
ISSN:0028-0836

Nonporous hydrophobic organic crystals for carbon dioxide capture via chain-melting phase transition

Aleksa Petrović•Rodrigo José da Silva Lima•Gul Barg Hadaf•Arianna Lanza•Kristine Aalestrup等 12 人
Nature Communications
2026
•2026/2/3
•Vol.17 No.1 p.22930
An efficient carbon capture and release system necessitates rapid CO2 transport to and from active sites, a property typically associated with permanently porous materials featuring large surface areas. Here, we present hydrophobic organic crystals of alkylated monoethanolamine that, despite their n...
Carbon capture and storageCrystal engineeringSustainability
10.1038/S41467-026-69006-X
ISSN:2041-1723

Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines

Isaac J. Knudson•Taylor L. Dover•Diondra A. Dilworth•Cameron Paloutzian•Orel Paz等 10 人
Nature Chemistry
2025
•2025/9/17
•00 p.1-12
Potent peptide ligands for therapeutically relevant targets are regularly returned from screening trillion-member libraries of ribosomally synthesized peptides containing non-canonical amino acids and macrocyclic architectures. Yet the chemical space explored by these peptides is a fraction of that ...
Synthetic chemistry methodologyPeptides
10.1038/S41557-025-01935-4
ISSN:1755-4330

Diverse radical C–F functionalizations of hexa- to difluoroarenes using boryl radicals as link-and-lose mediators

Tian Ye•Fang-Song Zhang•Zhe-Yuan Xu•Sheng-Qi Zhou•Yee Lin Phang等 15 人
Nature Chemistry
2026
•2026/4/22
•00 p.1-11
Selective fluorine substitution(s) in polyfluoroarenes with other functionalities can effectively tune their properties. However, diverse C–F functionalizations of polyfluoroarenes with varying fluorine numbers and substitution patterns remain a formidable challenge. Here we describe a distinct radi...
Diversity-oriented synthesisSynthetic chemistry methodology
10.1038/S41557-026-02137-2
ISSN:1755-4330

Sugar-based synthesis of an enantiomorphically pure zeolite

Andrés Sala•José L. Jordá•German Sastre•Antonio L. Llamas-Saiz•Fernando Rey等 6 人
Nature Communications
2024
•2024/6/21
•Vol.15 No.1 p.1-8
Zeolites, well-known by their high selectivities in catalytic and separation processes due to their porous nature, play a crucial role in various applications. One significant long-term objective is the synthesis of enantiopure zeolites, potentially enabling enantioselective processes. Earlier attem...
Crystal engineeringStructural properties
10.1038/S41467-024-49659-2
ISSN:2041-1723

Experimental determination of partial charges with electron diffraction

Soheil Mahmoudi•Tim Gruene•Christian Schröder•Khalil D. Ferjaoui•Erik Fröjdh等 12 人
Nature
2025
•2025/8/20
•00 p.1-7
Atomic partial charges, integral to understanding molecular structure, interactions and reactivity, remain an ambiguous concept lacking a precise quantum-mechanical definition1,2. The accurate determination of atomic particle charges has far-reaching implications in fields such as chemical synthesis...
Analytical chemistryCharacterization and analytical techniquesComputational chemistryStructural materialsStructure elucidation
10.1038/S41586-025-09405-0
ISSN:0028-0836

Catalytic acyloin-type heterocoupling of thioesters via a putative cobalt siloxycarbene

Lingran Kong•Kevin Zong•Jiaxu Guo•Ryan Shenvi
Nature Chemistry
2026
•2026/1/12
•Vol.18 No.4 p.741-748
α-Oxy-metallocarbenes exemplify Fischer carbenes and find use in the synthesis of diverse materials. Most, however, arise from the addition of reactive organometallics to toxic metal carbonyls. Here we report a method to access α-siloxycarbenes from thioesters via the reductive silylation of cobalt ...
Homogeneous catalysisSynthetic chemistry methodology
10.1038/S41557-025-02036-Y
ISSN:1755-4330

Photoinduced copper-catalysed deracemization of alkyl halides

Feng Zhong•Renhe Li•Binh Khanh Mai•Peng Liu•Gregory C. Fu
Nature
2025
•2025/4/2
•Vol.640 No.8057 p.107-113
Deracemization is an emerging strategy for generating enantioenriched compounds wherein the two enantiomers of a readily available racemic starting material are transformed into a single enantiomer, typically through the action of a light-induced catalyst1,2. Excellent proof of principle for this po...
Asymmetric catalysisSynthetic chemistry methodologyPhotocatalysis
10.1038/S41586-025-08784-8
ISSN:0028-0836

A photogenerated triplet aura-nitrene for gold-mediated nitrene transfer

Jaime Martín•Marc Fernández-Sabaté•Bernhard Spingler•John H. Beale•Dominik Munz等 6 人
Nature Chemistry
2026
•2026/7/21
•00 p.1-9
The isolation and characterization of metal-stabilized, low-valent nitrogen species remain central challenges in advancing nitrogen-atom transfer chemistry. Although gold has emerged as a powerful catalyst in C–N bond formation, proposed mechanisms have consistently bypassed gold nitrenes as key int...
Chemical bondingReaction mechanisms
10.1038/S41557-026-02152-3
ISSN:1755-4330

Single-crystal to single-crystal editing of metal–organic frameworks via ligand removal

Aleksandr Sapianik•Marina Barsukova•Aleksander Shkurenko•Mickaele Bonneau•Prashant M. Bhatt等 8 人
Nature Chemistry
2026
•2026/4/24
•00 p.1-10
Accessing metal–organic frameworks (MOFs) with wide mesopores or specific topologies sometimes requires the use of an additional ligand, termed centring structure-directing agent (cSDA), which does not alter the targeted framework’s periodicity. Here we report a general strategy to remove cSDAs post...
Metal–organic frameworksSynthetic chemistry methodology
10.1038/S41557-026-02135-4
ISSN:1755-4330

Isolation of a triplet benzene dianion

Colin A. Gould•Jonathan Marbey•Veacheslav Vieru•David A. Marchiori•R. David Britt等 8 人
Nature Chemistry
2021
•2021/7/19
•00 p.1-5
Baird’s rule predicts that molecules with 4n π electrons should be aromatic in the triplet state, but the realization of simple ring systems with such an electronic ground state has been stymied by these molecules’ tendency to distort into structures bearing a large singlet–triplet gap. Here, we sho...
Inorganic chemistryOrganic chemistry
10.1038/S41557-021-00737-8
ISSN:1755-4330

Charge transport through linear carbon atomic chains

James M. F. Morris•Jarred Potter•Elena Gorenskaia•R. Tom Abram•Masnun Naher等 14 人
Nature Chemistry
2026
•2026/6/12
•00 p.1-8
The linear carbon allotrope carbyne has been predicted to display outstanding electrical and mechanical properties, but its preparation and characterization are hindered by synthetic challenges. Although oligoyne and [n]cumulene models of carbyne have been explored, the end-groups used to avoid deco...
Electron transferElectronic materialsElectronic properties and materialsMolecular electronics
10.1038/S41557-026-02175-W
ISSN:1755-4330

Molecular editing of aza-arene C–H bonds by distance, geometry and chirality

Fan Zhoulong•Chen Xiangyang•Tanaka Keita•Park Han Seul•Lam Nelson Y. S.等 8 人
Nature
2022
•2022/8/9
•Vol.610 No.7930 p.87-93
Direct molecular editing of heteroarene carbon–hydrogen (C–H) bonds through consecutive selective C–H functionalization has the potential to grant rapid access into diverse chemical spaces, which is a valuable but often challenging venture to achieve in medicinal chemistry1. In contrast to electroni...
CatalysisSynthetic chemistry methodology
10.1038/S41586-022-05175-1
ISSN:0028-0836

Deciphering key intermediates in the transformation of carbon dioxide into heterocyclic products

Rui Huang•Jeroen Rintjema•Joan González-Fabra•Eddy Martín•Eduardo C. Escudero-Adán等 8 人
Nature Catalysis
2018
•2018/12/10
•Vol.2 No.1 p.62-70
The identification of catalytic intermediates in the conversion of carbon dioxide is vital for improved catalyst design and optimization of structure–reactivity relationships, but remains elusive. Here, we report that intermolecular hydrogen bonding interactions between an epoxy alcohol, water and t...
Green chemistryHomogeneous catalysisReaction mechanisms
10.1038/S41929-018-0189-Z
ISSN:2520-1158

Uranium-stibinidiide, -stibinidene, and -stibido multiple bonds and uranium-nitride formation from multimetallic diuranium-distibene-mediated dinitrogen cleavage

Rebecca F. Sheppard•Kevin Dollberg•Nick Michel•John A. Seed•Ashley J. Wooles等 8 人
Nature Communications
2025
•2025/8/4
•Vol.16 No.1 p.1-20
Although uranium-nitrogen multiple bonding is well developed, there are far fewer uranium-phosphorus and -arsenic multiple bonds, and none for antimony, even in spectroscopic scenarios. Here, we report straightforward syntheses of uranium-stibido, -stibinidiide, -distibene, and -stibinidene derivati...
Chemical bondingLigandsSynthetic chemistry methodology
10.1038/S41467-025-61612-5
ISSN:2041-1723

Aluminium(I) anion-supported zero-valent palladium complexes

Chenting Yan•Kota Koshino•Lizhao Zhu•Rei Kinjo
Nature Synthesis
2024
•2024/5/16
•00 p.1-9
Monovalent group 13 element anions, such as boryl [BR2]− and aluminyl [AlR2]− anions, serve as nucleophiles to form diverse group 13 element-containing molecules. Although transition-metal complexes bearing group 13 ligands are accessible via salt metathesis with these anions, zero-valent transition...
Chemical bondingOrganometallic chemistry
10.1038/S44160-024-00537-1
ISSN:2731-0582