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相关论文
2Conditional Monge Gap enables generalizable single-cell perturbation modelling
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Learning the response of single cells to various treatments offers great potential to enable targeted therapies. In this context, neural optimal transport has emerged as a principled methodological framework because it inherently accommodates the challenges of unpaired data induced by cell destructi...
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Squidiff: predicting cellular development and responses to perturbations using a diffusion model
Siyu He•Yuefei Zhu•Daniel Naveed Tavakol•Haotian Ye•Yeh-Hsing Lao等 14 人
Nature Methods
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•2025/11/3
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Single-cell sequencing has revolutionized our understanding of cellular heterogeneity and responses to environmental stimuli. However, mapping transcriptomic changes across diverse cell types in response to various stimuli and elucidating underlying disease mechanisms remains challenging. Here we pr...
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