Avon Longitudinal Study of Parents and Children
English
United Kingdom, Bristol
ALSPAC
数据描述
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a longitudinal cohort study following over 1,000 families from pregnancy until their children are at least 21 years old, and now extending to a third generation. The study has collected a vast amount of biological samples and phenotypic, environmental, genetic, and linkage data from multiple cohort groups over the past 30 years. Data includes questionnaires, clinical measures, biological resources, and information on the natural and built environment, as well as data derived from biological samples linked to routine health records. Data is available from original participants, their children (G1), and now the children of those participants (G2), capturing a unique three-generation perspective on health and lives.
www.bristol.ac.uk
IP: 137.222.0.38
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相关论文
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2022
•2022/6/16
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2021
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Npj Mental Health Research
2022
•2022/9/7
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2021
•2021/8/19
•Vol.6 No.1 p.1-12
Several abilities outside literacy proper are associated with reading and spelling, both phenotypically and genetically, though our knowledge of multivariate genomic covariance structures is incomplete. Here, we introduce structural models describing genetic and residual influences between traits to...
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Multi-level evidence of an allelic hierarchy of USH2A variants in hearing, auditory processing and speech/language outcomes
Peter A. Perrino•Lidiya Talbot•Rose Kirkland•Amanda Hill•Amanda R. Rendall等 12 人
Communications Biology
2020
•2020/4/20
•Vol.3 No.1 p.1-14
Language development builds upon a complex network of interacting subservient systems. It therefore follows that variations in, and subclinical disruptions of, these systems may have secondary effects on emergent language. In this paper, we consider the relationship between genetic variants, hearing...
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10.1038/S42003-020-0885-5
ISSN:2399-3642
Waist-circumference-to-height-ratio had better longitudinal agreement with DEXA-measured fat mass than BMI in 7237 children
Andrew O. Agbaje
Pediatric Research
2024
•2024/3/5
•00 p.1-12
The absolute agreement of surrogate measures of adiposity with dual-energy X-ray absorptiometry (DEXA)-measured body composition was examined. Over a 15-year follow-up, 7237 (3667 females) nine-year-old children from the Avon Longitudinal Study of Parents and Children (ALSPAC) UK birth coh...
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10.1038/S41390-024-03112-8
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Npj Mental Health Research
2024
•2024/5/9
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10.1038/S44184-024-00066-X
ISSN:2731-4251
Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci
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Nature Communications
2019
•2019/3/5
•Vol.10 No.1 p.1-12
Mouth ulcers are the most common ulcerative condition and encompass several clinical diagnoses, including recurrent aphthous stomatitis (RAS). Despite previous evidence for heritability, it is not clear which specific genetic loci are implicated in RAS. In this genome-wide association study (n = 461...
Aphthous stomatitisDisease geneticsEpidemiologyGenome-wide association studies
10.1038/S41467-019-08923-6
ISSN:2041-1723
Leptin receptor co-expression gene network moderates the effect of early life adversity on eating behavior in children
de Lima Randriely Merscher Sobreira•Barth Barbara•Mar Arcego Danusa•de Mendonça Filho Euclides José•Patel Sachin等 14 人
Communications Biology
2022
•2022/10/14
•Vol.5 No.1 p.1-10
Leptin influences eating behavior. Exposure to early adversity is associated with eating behaviour disorders and metabolic syndrome, but the role of the leptin receptor on this relationship is poorly explored. We investigated whether individual differences in brain region specific leptin receptor (L...
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ISSN:2399-3642
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Molecular Psychiatry
2022
•2022/4/7
•00 p.1-9
Inhibitory control deficits are prevalent in multiple neuropsychiatric conditions. The communication- as well as the connectivity- between corticolimbic regions of the brain are fundamental for eliciting inhibitory control behaviors, but early markers of vulnerability to this behavioral trait are ye...
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10.1038/S41380-022-01533-7
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