Avon Longitudinal Study of Parents and Children
English
United Kingdom, Bristol
ALSPAC
数据描述
The dataset described is the Avon Longitudinal Study of Parents and Children (ALSPAC), a research resource offering access to data and samples from a long-term cohort study. Its purpose is to support health and development research, and it contains survey data, biomedical measurements, and biological samples from participants. Researchers can request existing data and samples or collect new ones through activities like whole cohort questionnaires and clinic-based measurements, with access governed by a formal policy and an executive committee.
www.bristol.ac.uk
IP: 137.222.0.38
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2023
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Nature Genetics
2023
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Npj Science Of Learning
2021
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Several abilities outside literacy proper are associated with reading and spelling, both phenotypically and genetically, though our knowledge of multivariate genomic covariance structures is incomplete. Here, we introduce structural models describing genetic and residual influences between traits to...
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Multi-level evidence of an allelic hierarchy of USH2A variants in hearing, auditory processing and speech/language outcomes
Peter A. Perrino•Lidiya Talbot•Rose Kirkland•Amanda Hill•Amanda R. Rendall等 12 人
Communications Biology
2020
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Language development builds upon a complex network of interacting subservient systems. It therefore follows that variations in, and subclinical disruptions of, these systems may have secondary effects on emergent language. In this paper, we consider the relationship between genetic variants, hearing...
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10.1038/S42003-020-0885-5
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Nature Human Behaviour
2022
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Children who experience adversities have an elevated risk of mental health problems. However, the extent to which adverse childhood experiences (ACEs) cause mental health problems remains unclear, as previous associations may partly reflect genetic confounding. In this Registered Report, we used DNA...
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10.1038/S41562-022-01482-9
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Andrew O. Agbaje
Pediatric Research
2024
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The absolute agreement of surrogate measures of adiposity with dual-energy X-ray absorptiometry (DEXA)-measured body composition was examined. Over a 15-year follow-up, 7237 (3667 females) nine-year-old children from the Avon Longitudinal Study of Parents and Children (ALSPAC) UK birth coh...
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10.1038/S41390-024-03112-8
ISSN:0031-3998
An exploration into the causal relationships between educational attainment, intelligence, and wellbeing: an observational and two-sample Mendelian randomisation study
J. M. Armitage•R. E. Wootton•O. S. P. Davis•C. M. A. Haworth
Npj Mental Health Research
2024
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Educational attainment is associated with a range of positive outcomes, yet its impact on wellbeing is unclear, and complicated by high correlations with intelligence. We use genetic and observational data to investigate for the first time, whether educational attainment and intelligence are causall...
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10.1038/S44184-024-00066-X
ISSN:2731-4251
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Ruby S. M. Tsang•Daniel Stow•Alex S. F. Kwong•Nicholas A. Donnelly•Holly Fraser等 12 人
Molecular Psychiatry
2025
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10.1038/S41380-025-03311-7
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Roelof A. J. Smit•Kaitlin H. Wade•Qin Hui•Joshua D. Arias•Xianyong Yin等 627 人
Nature Medicine
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Nature Communications
2019
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10.1038/S41467-019-08923-6
ISSN:2041-1723
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Nature Communications
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10.1038/S41467-025-63842-Z
ISSN:2041-1723
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Alexandre A. Lussier•Brooke J. Smith•Jonah Fisher•Mannan Luo•Janine Cerutti等 18 人
Nature Mental Health
2024
•2024/12/2
•00 p.1-10
Experiences of childhood adversity can double the risk for depression. Although the mechanisms underlying this relationship remain unclear, DNA methylation (DNAm) has emerged as a potential pathway to explain the link between adversity and depression. We thus investigated whether epigenome-wide DNAm...
DepressionEpigenomicsRisk factors
10.1038/S44220-024-00345-8
ISSN:2731-6076
Syndrome-informed phenotyping identifies a polygenic background for achondroplasia-like facial variation in the general population
Michiel Vanneste•Hanne Hoskens•Seppe Goovaerts•Harold Matthews•Jay Devine等 17 人
Nature Communications
2024
•2024/12/2
•Vol.15 No.1 p.1-13
Human craniofacial shape is highly variable yet highly heritable with numerous genetic variants interacting through multiple layers of development. Here, we hypothesize that Mendelian phenotypes represent the extremes of a phenotypic spectrum and, using achondroplasia as an example, we introduce a s...
Genetic variationGenome-wide association studiesHeritable quantitative trait
10.1038/S41467-024-54839-1
ISSN:2041-1723
Trans-eQTL mapping prioritises USP18 as a negative regulator of interferon response at a lupus risk locus
Krista Freimann•Anneke Brümmer•Robert Warmerdam•Tarran S. Rupall•Ana Laura Hernández-Ledesma等 20 人
Nature Communications
2025
•2025/10/2
•Vol.16 No.1 p.1-15
Although genome-wide association studies have provided valuable insights into the genetic basis of complex traits and diseases, translating these findings to causal genes and their downstream mechanisms remains challenging. We performed trans expression quantitative trait locus (trans-eQTL) meta-ana...
Gene regulationGene regulatory networksImmunogeneticsTranscriptomics
10.1038/S41467-025-63856-7
ISSN:2041-1723