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相关论文
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Arun Balachandran•Heming Pei•Yifan Shi•John R. Beard•Avshalom Caspi等 16 人
Nature Aging
2025
•2025/5/26
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As societies age, policy makers need tools to understand how demographic aging will affect population health and to develop programs to increase healthspan. The current metrics used for policy do not distinguish differences caused by early-life factors, like prenatal care and nutrition, from those c...
AgeingDiagnostic markers
10.1038/S43587-025-00866-6
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Early-life exposure to sugar rationing and long-term risk of depression and anxiety: a population-based natural experiment
Binyu Liu•Zhuoshuai Liang•Xiaoyang Li•Huizhen Jin•Ruofei Li等 16 人
Molecular Psychiatry
2026
•2026/7/23
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Early-life nutritional environments, particularly during the first 1000 days of life, may have long-term implications for mental health. We investigated the association between early-life exposure to UK sugar rationing, a population-wide policy implemented during and after World War II, and the risk...
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Linking socioeconomic status to depressive symptoms in aging populations
Huijie Xu•Zheng Zhang•Yanyue Ye•Jiansong Zhou•Xia Cao
Nature Mental Health
2025
•2025/11/13
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Late-life depressive symptoms remain a pressing global health issue, particularly among older adults with persistent socioeconomic disadvantages. While previous studies have linked socioeconomic status (SES) to mental health, few have integrated dynamic SES trajectories, psychosocial mechanisms and ...
EpidemiologyMedical research
10.1038/S44220-025-00533-0
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The mediating role of systemic inflammation and moderating role of racialization in disparities in incident dementia
César Higgins Tejera•Erin B. Ware•Margaret T. Hicken•Lindsay C. Kobayashi•Herong Wang等 9 人
Communications Medicine
2024
•2024/7/13
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Exposure to systemic racism is linked to increased dementia burden. To assess systemic inflammation as a potential pathway linking exposure to racism and dementia disparities, we investigated the mediating role of C-reactive protein (CRP), a systemic inflammation marker, and the moderating role of t...
DementiaEpidemiology
10.1038/S43856-024-00569-W
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A meta-analysis of loneliness and risk of dementia using longitudinal data from >600,000 individuals
Martina Luchetti•Damaris Aschwanden•Amanda A. Sesker•Xianghe Zhu•Páraic S. O’Súilleabháin等 8 人
Nature Mental Health
2024
•2024/10/9
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Loneliness is one critical risk factor for cognitive health. Here we combined data from ongoing aging studies and the published literature and provide the largest meta-analysis on the association between loneliness and dementia (k = 21 samples, N = 608,561) and cognitive impairment (k = 16, N = 103,...
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Genetic associations with parental investment from conception to wealth inheritance in six cohorts
Jasmin Wertz•Terrie E. Moffitt•Louise Arseneault•J. C. Barnes•Michel Boivin等 17 人
Nature Human Behaviour
2023
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Genetic inheritance is not the only way parents’ genes may affect children. It is also possible that parents’ genes are associated with investments into children’s development. We examined evidence for links between parental genetics and parental investments, from the prenatal period through to adul...
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10.1038/S41562-023-01618-5
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Observational and genetic evidence disagree on the association between loneliness and risk of multiple diseases
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Nature Human Behaviour
2024
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Loneliness—the subjective experience of social disconnection—is now widely regarded as a health risk factor. However, whether the associations between loneliness and multiple diseases are consistent with causal effects remains largely unexplored. Here we combined behavioural, genetic and hospitaliza...
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10.1038/S41562-024-01970-0
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Positive association between Internet use and mental health among adults aged ≥50 years in 23 countries
Yan Luo•Paul Siu Fai Yip•Qingpeng Zhang
Nature Human Behaviour
2024
•2024/11/18
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The Internet is increasingly important in addressing age-related mental health challenges. We used linear mixed models and meta-analyses to examine the association between Internet use and mental health among 87,559 adults aged ≥50 years from 23 countries. Internet use was associated with fewer depr...
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10.1038/S41562-024-02048-7
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Gene expression composite scores of cellular senescence predict aging health outcomes in the Health and Retirement Study
Qiao Wu•Eric T. Klopack•Jung Ki Kim•T. Em Arpawong•Bharat Thyagarajan等 9 人
Nature Communications
2025
•2025/10/10
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Cellular senescence, a hallmark of aging, can be quantified by the gene expression composite scores for the canonical senescence pathway (CSP), senescence initiating pathway (SIP), senescence response pathway (SRP), a summary of the three, and the SenMayo gene list; however, these have not been prob...
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10.1038/S41467-025-64835-8
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