The Alzheimer’s Disease Neuroimaging Initiative (ADNI)
English
United States, Sunnyvale
Image Data Sets MRI
数据描述
The Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset is a longitudinal, multi-center observational research resource focused on validating biomarkers for Alzheimer’s disease clinical trials. It contains aggregate-level clinical data collected over time from more than 2,500 participants across the United States and Canada, along with linked study cohort information, subject characteristics, clinical assessments and questionnaires, PET and MRI imaging data, MRI quality control and preprocessing outputs, numerical imaging datasets, scanner protocols, biofluid biomarkers, genetics and related omics, neuropathology, remotely collected ADNI4 data, and biospecimen information. Its primary application is supporting Alzheimer’s disease and related dementia research by enabling broad data sharing and biomarker discovery.
adni.loni.usc.edu
IP: 68.181.124.24
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相关论文
88Non-coding variability at the APOE locus contributes to the Alzheimer’s risk
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Nature Communications
2019
•2019/7/25
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Alzheimer’s disease (AD) is a leading cause of mortality in the elderly. While the coding change of APOE-ε4 is a key risk factor for late-onset AD and has been believed to be the only risk factor in the APOE locus, it does not fully explain the risk effect conferred by the locus. Here, we report the...
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Associations between sleep quality, plasma neurofilament light, and cognition in older adults without dementia
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The relationship between sleep quality, neurofilament light chain (NFL), and cognitive impairment, including the potential effect of plasma NFL in this association, remains unclear. Using the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort, we excluded individuals with dementia or a histor...
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ISSN:1759-4758
Exploiting macro- and micro-structural brain changes for improved Parkinson’s disease classification from MRI data
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2026
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2026
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ISSN:2730-664X
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2023
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2026
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ISSN:2041-1723
Deep learning-based polygenic risk analysis for Alzheimer’s disease prediction
Zhou Xiaopu•Chen Yu•Ip Fanny C. F.•Jiang Yuanbing•Cao Han等 23 人
Communications Medicine
2023
•2023/4/6
•Vol.3 No.1 p.1-20
The polygenic nature of Alzheimer’s disease (AD) suggests that multiple variants jointly contribute to disease susceptibility. As an individual’s genetic variants are constant throughout life, evaluating the combined effects of multiple disease-associated genetic risks enables reliable AD risk predi...
Alzheimer's diseaseMedical genomics
10.1038/S43856-023-00269-X
ISSN:2730-664X
APOE4 homozygozity represents a distinct genetic form of Alzheimer’s disease
Juan Fortea•Jordi Pegueroles•Daniel Alcolea•Olivia Belbin•Oriol Dols-Icardo等 14 人
Nature Medicine
2024
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•00 p.1-8
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Nature Aging
2026
•2026/5/15
•00 p.1-20
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ISSN:2662-8465
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Nature Communications
2025
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•Vol.16 No.1 p.1-15
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Nature Communications
2024
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•Vol.15 No.1 p.1-9
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Nature
2024
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•00 p.1-9
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Translational Psychiatry
2026
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Guoshi Li•Li-Ming Hsu•Ye Wu•Andrea C. Bozoki•Yen-Yu Ian Shih等 6 人
Communications Medicine
2025
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Alzheimer’s disease (AD) is a serious neurodegenerative disorder without a clear understanding of pathophysiology. Recent experimental data have suggested neuronal excitation-inhibition (E-I) imbalance as an essential element of AD pathology, but E-I imbalance has not been systematically mapped out ...
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10.1038/S43856-025-00736-7
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Zixiang Luo•Kaining Peng•Zhichao Liang•Shengyuan Cai•Chenyu Xu等 9 人
Nature Methods
2025
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Effective connectivity (EC), which reflects the causal interactions between brain regions, is fundamental to understanding information processing in the brain; however, traditional methods for obtaining EC, which rely on neural responses to stimulation, are often invasive or limited in spatial cover...
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10.1038/S41592-025-02654-X
ISSN:1548-7091
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Qizhen Lan•Aaron Choi•Jun Ma•Bo Wang•Zhongming Zhao等 7 人
Npj Health Systems
2026
•2026/7/3
•Vol.3 No.1 p.580
Deploying medical image segmentation models in routine clinical workflows is often constrained by on-premises infrastructure, where computational resources are fixed and cloud-based inference may be restricted by governance and security policies. While high-capacity models achieve strong segmentatio...
Computational biology and bioinformaticsEngineeringHealth careMathematics and computing
10.1038/S44401-026-00108-W
ISSN:3005-1959
White matter micro- and macrostructure brain charts for the human lifespan
Michael E. Kim•Chenyu Gao•Karthik Ramadass•Nancy R. Newlin•Praitayini Kanakaraj等 30 人
Nature
2026
•2026/5/13
•00 p.1-11
The human brain relies on a complex network of connections to function, with white matter acting as the primary communication highway between different brain regions1,2. Disruptions in these critical communication pathways are linked to several neurological, psychiatric and developmental disorders3,...
Brain imagingData processing
10.1038/S41586-026-10454-2
ISSN:0028-0836
Genetic variants associated with longitudinal changes in brain structure across the lifespan
Brouwer Rachel M.•Klein Marieke•Grasby Katrina L.•Schnack Hugo G.•Jahanshad Neda等 200 人
Nature Neuroscience
2022
•2022/4/5
•00 p.1-12
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, t...
Genetics of the nervous systemGenome-wide association studies
10.1038/S41593-022-01042-4
ISSN:1097-6256
An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease
Jiang Yuanbing•Zhou Xiaopu•Wong Hiu Yi•Ouyang Li•Ip Fanny C. F.等 29 人
Nature Aging
2022
•2022/7/15
•Vol.2 No.7 p.616-634
Changes in the levels of circulating proteins are associated with Alzheimer’s disease (AD), whereas their pathogenic roles in AD are unclear. Here, we identified soluble ST2 (sST2), a decoy receptor of interleukin-33–ST2 signaling, as a new disease-causing factor in AD. Increased circulating sST2 le...
AgeingAlzheimer's diseaseGenetics of the nervous systemNeuroimmunology
10.1038/S43587-022-00241-9
ISSN:2662-8465
Rare variants in IFFO1, DTNB, NLRC3 and SLC22A10 associate with Alzheimer’s disease CSF profile of neuronal injury and inflammation
Neumann Alexander•Küçükali Fahri•Bos Isabelle•Vos Stephanie J. B.•Engelborghs Sebastiaan等 35 人
Molecular Psychiatry
2022
•2022/2/16
•00 p.1-10
Alzheimer’s disease (AD) biomarkers represent several neurodegenerative processes, such as synaptic dysfunction, neuronal inflammation and injury, as well as amyloid pathology. We performed an exome-wide rare variant analysis of six AD biomarkers (β-amyloid, total/phosphorylated tau, NfL, YKL-40, an...
Diagnostic markersGenetics
10.1038/S41380-022-01437-6
ISSN:1359-4184
Brain aging patterns in a large and diverse cohort of 49,482 individuals
Zhijian Yang•Junhao Wen•Guray Erus•Sindhuja T. Govindarajan•Randa Melhem等 53 人
Nature Medicine
2024
•2024/8/15
•00 p.1-12
Brain aging process is influenced by various lifestyle, environmental and genetic factors, as well as by age-related and often coexisting pathologies. Magnetic resonance imaging and artificial intelligence methods have been instrumental in understanding neuroanatomical changes that occur during agin...
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10.1038/S41591-024-03144-X
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The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory
Nicolai Franzmeier•Anna Rubinski•Julia Neitzel•Michael Ewers
Nature Communications
2019
•2019/4/16
•Vol.10 No.1 p.1-12
The single nucleotide polymorphism (SNP) rs744373 in the bridging integrator-1 gene (BIN1) is a risk factor for Alzheimer’s disease (AD). In the brain, BIN1 is involved in endocytosis and sustaining cytoskeleton integrity. Post-mortem and in vitro studies suggest that BIN1-associated AD risk is medi...
Alzheimer's diseaseDisease genetics
10.1038/S41467-019-09564-5
ISSN:2041-1723
Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study
Chen Shi-Dong•Lu Jia-Ying•Li Hong-Qi•Yang Yu-Xiang•Jiang Jie-Hui等 10 人
Translational Psychiatry
2021
•2021/9/18
•Vol.11 No.1 p.1-12
A biological research framework to define Alzheimer’ disease with dichotomized biomarker measurement was proposed by National Institute on Aging–Alzheimer’s Association (NIA–AA). However, it cannot characterize the hierarchy spreading pattern of tau pathology. To reflect in vivo tau progression usin...
BiomarkersNeuroscience
10.1038/S41398-021-01602-5
ISSN:2158-3188
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients
Kondo Takayuki•Hara Norikazu•Koyama Satoshi•Yada Yuichiro•Tsukita Kayoko等 12 人
Nature Aging
2022
•2022/2/17
•Vol.2 No.2 p.125-139
Genome-wide association studies have demonstrated that polygenic risks shape Alzheimer’s disease (AD). To elucidate the polygenic architecture of AD phenotypes at a cellular level, we established induced pluripotent stem cells from 102 patients with AD, differentiated them into cortical neurons and ...
AgeingAlzheimer's diseaseBioinformaticsGenome-wide association studiesNeurological models
10.1038/S43587-021-00158-9
ISSN:2662-8465
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality
Tian Ye Ella•Cropley Vanessa•Maier Andrea B.•Lautenschlager Nicola T.•Breakspear Michael等 6 人
Nature Medicine
2023
•2023/4/6
•00 p.1-11
Biological aging of human organ systems reflects the interplay of age, chronic disease, lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes from the UK Biobank, we establish normative models of biological age for three brain and seven body systems. Here we find ...
DiseasesNeural ageingPredictive markersTranslational research
10.1038/S41591-023-02296-6
ISSN:1078-8956
Divergent white matter metabolic signature patterns indicate impending cognitive decline in aging and dementia
Wen Zhang•Sheelakumari Raghavan•Jianqiao Tian•Scott A. Przybelski•Heather J. Wiste等 15 人
Nature Communications
2026
•2026/3/19
0White matter (WM) is a key substrate for interregional neural communication and cognitive function but the role of WM glucose metabolism in cognitive aging has been understudied. Using multimodal neuroimaging (MRI, FDG-PET, amyloid-PET) from 3142 participants (15,287 visits) across two studies, we e...
DementiaPredictive markersWhite matter disease
10.1038/S41467-026-70707-6
ISSN:2041-1723
Predicting categorical and continuous Alzheimer’s disease outcomes from a single MRI scan
Daren Ma•Christabelle Pabalan•Abhejit Rajagopal•Akanksha Akanksha•Yannet Interian等 7 人
Nature Aging
2026
•2026/5/18
•Vol.6 No.5 p.1121-1137
Deep learning (DL) has shown success in predicting Alzheimer’s disease (AD) diagnosis, yet continuous measures such as cognitive assessment remain critical for richer prognosis, trajectory tracking and clinical trial enrichment. Current neurocognitive batteries are time-consuming, and the few DL mod...
Alzheimer's diseaseCognitive ageing
10.1038/S43587-026-01121-2
ISSN:2662-8465
A lightweight CVTC model for accurate Alzheimer’s MRI analysis and lesion annotation
Yiwei Lu•Hongcheng Yu•Tianbao Li•Yuting Meng•Jianbo Lu等 6 人
Npj Digital Medicine
2026
•2026/1/8
•Vol.9 No.1 p.380
In clinical practice, MRI images are widely used to diagnose neurodegenerative diseases like Alzheimer’s disease (AD). However, complex MRI patterns often mimic normal aging, relying on subjective experience and risking misdiagnosis. This paper proposes the Cross Vision Transformer with Coordinate (...
Alzheimer's disease
10.1038/S41746-025-02212-X
ISSN:2398-6352
Proteomic changes in Alzheimer’s disease associated with progressive Aβ plaque and tau tangle pathologies
Alexa Pichet Binette•Chris Gaiteri•Malin Wennström•Atul Kumar•Ines Hristovska等 16 人
Nature Neuroscience
2024
•2024/8/26
•00 p.1-12
Proteomics can shed light on the dynamic and multifaceted alterations in neurodegenerative disorders like Alzheimer’s disease (AD). Combining radioligands measuring β-amyloid (Aβ) plaques and tau tangles with cerebrospinal fluid proteomics, we uncover molecular events mirroring different stages of A...
Alzheimer's disease
10.1038/S41593-024-01737-W
ISSN:1097-6256
Astrocyte-related proteins mediate the association of YWHAG with Alzheimer’s pathology and enhance its diagnostic value
Zihao Zhang•Pengcheng Huang•Yirong Yang•Hailun Wu•Xuerui Yao等 15 人
Translational Psychiatry
2026
•2026/4/9
0Recent advances have identified YWHAG as a promising synaptic biomarker, with evidence showing that the YWHAG:NPTX2 ratio strongly predicts cognitive decline and Alzheimer’s disease (AD) progression independent of amyloid and tau pathology. However, the links between YWHAG and astrocytic processes-k...
Diagnostic markersLearning and memory
10.1038/S41398-026-04020-7
ISSN:2158-3188
Human lifespan changes in the brain’s functional connectome
Lianglong Sun•Tengda Zhao•Xinyuan Liang•Mingrui Xia•Qiongling Li等 69 人
Nature Neuroscience
2025
•2025/4/3
•Vol.28 No.4 p.891-901
Functional connectivity of the human brain changes through life. Here, we assemble task-free functional and structural magnetic resonance imaging data from 33,250 individuals at 32 weeks of postmenstrual age to 80 years from 132 global sites. We report critical inflection points in the nonlinear gro...
Cognitive neuroscienceFunctional magnetic resonance imaging
10.1038/S41593-025-01907-4
ISSN:1097-6256
Individual-specific functional connectivity improves prediction of Alzheimer’s disease’s symptoms in elderly people regardless of APOE ε4 genotype
Lin Hua•Fei Gao•Xiaoluan Xia•Qiwei Guo•Yonghua Zhao等 7 人
Communications Biology
2023
•2023/5/31
•Vol.6 No.1 p.1-11
To date, reliable biomarkers remain unclear that could link functional connectivity to patients’ symptoms for detecting and predicting the process from normal aging to Alzheimer’s disease (AD) in elderly people with specific genotypes. To address this, individual-specific functional connectivity is ...
Alzheimer's diseasePredictive markers
10.1038/S42003-023-04952-6
ISSN:2399-3642
Similarity-driven multi-view embeddings from high-dimensional biomedical data
Brian B. Avants•Nicholas J. Tustison•James R. Stone
Nature Computational Science
2021
•2021/2/22
•Vol.1 No.2 p.143-152
Diverse, high-dimensional modalities collected in large cohorts present new opportunities for the formulation and testing of integrative scientific hypotheses. Similarity-driven multi-view linear reconstruction (SiMLR) is an algorithm that exploits inter-modality relationships to transform large sci...
Computational biology and bioinformaticsComputational science
10.1038/S43588-021-00029-8
ISSN:2662-8457
Genetic risk for attention-deficit/hyperactivity disorder predicts cognitive decline and development of Alzheimer’s disease pathophysiology in cognitively unimpaired older adults
Leffa Douglas T.•Ferrari-Souza João Pedro•Bellaver Bruna•Tissot Cécile•Ferreira Pamela C. L.等 22 人
Molecular Psychiatry
2022
•2022/12/8
•Vol.28 No.3 p.1248-1255
Attention-deficit/hyperactivity disorder (ADHD) persists in older age and is postulated as a risk factor for cognitive impairment and Alzheimer’s Disease (AD). However, these findings rely primarily on electronic health records and can present biased estimates of disease prevalence. An obstacle to i...
ADHDPrognostic markers
10.1038/S41380-022-01867-2
ISSN:1359-4184
The impact of blood MCP-1 levels on Alzheimer’s disease with genetic variation at the NAV3 and UNC5C loci
Jinghan Huang•Yixuan Wang•Thor D. Stein•Ting Fang Alvin Ang•Yibo Zhu等 12 人
Translational Psychiatry
2025
•2025/8/19
•Vol.15 No.1 p.1-11
Monocyte chemoattractant protein-1 (MCP-1), a cytokine involved in peripheral inflammation, has been shown to modulate established Alzheimer’s disease (AD) loci. In this study, we hypothesized that blood MCP-1 levels may impact the associations of other genetic variants with AD risk beyond the well-...
BiomarkersDiseasesPersonalized medicine
10.1038/S41398-025-03542-W
ISSN:2158-3188
Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
Ganna Leonenko•Emily Baker•Joshua Stevenson-Hoare•Annerieke Sierksma•Mark Fiers等 8 人
Nature Communications
2021
•2021/7/23
•Vol.12 No.1 p.1-10
Polygenic Risk Scores (PRS) for AD offer unique possibilities for reliable identification of individuals at high and low risk of AD. However, there is little agreement in the field as to what approach should be used for genetic risk score calculations, how to model the effect of APOE, what the optim...
Alzheimer's diseaseGeneticsGenome-wide association studiesNeurology
10.1038/S41467-021-24082-Z
ISSN:2041-1723
Association of choroid plexus volume with white matter microstructure, glymphatic function, and peripheral systemic inflammation in Alzheimer’s disease
Huwei Xia•Yijia Feng•Han Zhu•Danlu Yang•Chaoqun Wang等 11 人
Translational Psychiatry
2025
•2025/7/11
•Vol.15 No.1 p.1-9
There has been growing attention to the role of choroid plexus (CP) in neurodegenerative diseases. However, its relationship with various pathophysiological changes in Alzheimer’s Disease (AD) remains unclear. The purpose of this study is to investigate the relationship between CP volume (CPV) and w...
DiseasesPredictive markers
10.1038/S41398-025-03432-1
ISSN:2158-3188
Sex differences in plasma p-tau181 associations with Alzheimer’s disease biomarkers, cognitive decline, and clinical progression
Tsiknia Amaryllis A.•Edland Steven D.•Sundermann Erin E.•Reas Emilie T.•Brewer James B.等 7 人
Molecular Psychiatry
2022
•2022/6/29
•Vol.27 No.10 p.4314-4322
Studies have shown that women on the Alzheimer’s disease (AD) continuum have more pathological tau in the brain and cerebrospinal fluid (CSF), than men. Some studies have found that higher levels of tau biomarkers are more strongly associated with clinical AD, cognitive decline and neurodegeneration...
NeurosciencePredictive markers
10.1038/S41380-022-01675-8
ISSN:1359-4184
β-amyloid and tau drive early Alzheimer’s disease decline while glucose hypometabolism drives late decline
Tyler C. Hammond•Xin Xing•Chris Wang•David Ma•Kwangsik Nho等 13 人
Communications Biology
2020
•2020/7/6
•Vol.3 No.1 p.1-13
Clinical trials focusing on therapeutic candidates that modify β-amyloid (Aβ) have repeatedly failed to treat Alzheimer’s disease (AD), suggesting that Aβ may not be the optimal target for treating AD. The evaluation of Aβ, tau, and neurodegenerative (A/T/N) biomarkers has been proposed for classify...
Learning algorithmsPredictive markers
10.1038/S42003-020-1079-X
ISSN:2399-3642
Polygenic resilience scores capture protective genetic effects for Alzheimer’s disease
Hou Jiahui•Hess Jonathan L.•Armstrong Nicola•Bis Joshua C.•Grenier-Boley Benjamin等 34 人
Translational Psychiatry
2022
•2022/7/25
•Vol.12 No.1 p.1-11
Polygenic risk scores (PRSs) can boost risk prediction in late-onset Alzheimer’s disease (LOAD) beyond apolipoprotein E (APOE) but have not been leveraged to identify genetic resilience factors. Here, we sought to identify resilience-conferring common genetic variants in (1) unaffected individuals h...
Clinical geneticsComparative genomicsLong-term memory
10.1038/S41398-022-02055-0
ISSN:2158-3188
BrainParc: unified lifespan brain parcellation from structural magnetic resonance images
Jiameng Liu•Feihong Liu•Kaicong Sun•Zhiming Cui•Tianyang Sun等 16 人
Nature Computational Science
2026
•2026/3/11
•00 p.1-15
Accurate brain parcellation from structural MRI across the human lifespan is essential for advancing neuroimaging and neuroscience studies. However, existing methods often struggle to generalize owing to intensity and contrast variations across brain maturation, aging and differences in MRI acquisit...
Brain imagingComputational neuroscienceMagnetic resonance imaging
10.1038/S43588-026-00963-5
ISSN:2662-8457
Lower functional hippocampal redundancy in mild cognitive impairment
Stephanie Langella•Muhammad Usman Sadiq•Peter J. Mucha•Kelly S. Giovanello•Eran Dayan
Translational Psychiatry
2021
•2021/1/18
•Vol.11 No.1 p.1-12
With an increasing prevalence of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) in response to an aging population, it is critical to identify and understand neuroprotective mechanisms against cognitive decline. One potential mechanism is redundancy: the existence of duplicate elements...
DiseasesNeuroscience
10.1038/S41398-020-01166-W
ISSN:2158-3188
Latent space-based network analysis for brain–behavior linking in neuroimaging
Selena Wang•Xinzhi Zhang•Yunhe Liu•Wanwan Xu•Xinyuan Tian等 6 人
Nature Methods
2025
•2025/12/4
•00 p.1-11
We propose a latent space-based statistical network analysis (LatentSNA) method that implements network science in a generative Bayesian framework, preserves neurologically meaningful brain topology and improves statistical power for imaging biomarker detection. LatentSNA (1) addresses the lack of p...
Network topologyStatistical methods
10.1038/S41592-025-02896-9
ISSN:1548-7091
Variable and interactive effects of Sex, APOE ε4 and TREM2 on the deposition of tau in entorhinal and neocortical regions
Joseph Giorgio•Caroline Jonson•Yilin Wang•Jennifer S. Yokoyama•Jingshen Wang等 6 人
Nature Communications
2025
•2025/7/1
•Vol.16 No.1 p.1-12
The canonical Alzheimer’s Disease (AD) pathological cascade posits that the accumulation of amyloid beta (Aβ) is the initiating event, accelerating the accumulation of tau in the entorhinal cortex (EC), which subsequently spreads into the neocortex. Here in a multi-cohort study (ADNI, A4, HABS-HD) o...
Alzheimer's disease
10.1038/S41467-025-60370-8
ISSN:2041-1723
Aβ-induced vulnerability propagates via the brain’s default mode network
Tharick A. Pascoal•Sulantha Mathotaarachchi•Min Su Kang•Sara Mohaddes•Monica Shin等 17 人
Nature Communications
2019
•2019/6/4
•Vol.10 No.1 p.1-13
The link between brain amyloid-β (Aβ), metabolism, and dementia symptoms remains a pressing question in Alzheimer’s disease. Here, using positron emission tomography ([18F]florbetapir tracer for Aβ and [18F]FDG tracer for glucose metabolism) with a novel analytical framework, we found that Aβ aggreg...
Alzheimer's diseaseDementiaNeurosciencePositron-emission tomography
10.1038/S41467-019-10217-W
ISSN:2041-1723
In vivo-measured Lewy body pathology is associated with neuropsychiatric symptoms across the Alzheimer’s disease continuum
Douglas Teixeira Leffa•Guilherme Povala•Pamela C. L. Ferreira•João Pedro Ferrari-Souza•Guilherme Bauer-Negrini等 18 人
Molecular Psychiatry
2025
•2025/12/14
•00 p.1-9
Intracellular alpha-synuclein aggregates, known as Lewy bodies (LB), are commonly observed in Alzheimer’s disease (AD) dementia. Post-mortem studies have shown a higher frequency of neuropsychiatric symptoms among individuals with AD and LB co-pathology. However, the effects of in vivo-measured LB p...
DiseasesPredictive markers
10.1038/S41380-025-03400-7
ISSN:1359-4184
Longitudinal plasma phosphorylated tau 181 tracks disease progression in Alzheimer’s disease
Shi-Dong Chen•Yu-Yuan Huang•Xue-Ning Shen•Yu Guo•Lan Tan等 7 人
Translational Psychiatry
2021
•2021/6/12
•Vol.11 No.1 p.1-10
To assess plasma phosphorylated tau181 (p-tau181) as a progression biomarker in Alzheimer’s disease (AD), we examined longitudinal plasma p-tau181 of 1184 participants (403 cognitively normal (CN), 560 patients with mild cognitive impairment (MCI), and 221 with AD dementia) from Alzheimer’s Disease ...
BiomarkersNeuroscience
10.1038/S41398-021-01476-7
ISSN:2158-3188
Fingerprints of brain disease: connectome identifiability in Alzheimer’s disease
Sara Stampacchia•Saina Asadi•Szymon Tomczyk•Federica Ribaldi•Max Scheffler等 15 人
Communications Biology
2024
•2024/9/18
•Vol.7 No.1 p.1-16
Functional connectivity patterns in the human brain, like the friction ridges of a fingerprint, can uniquely identify individuals. Does this “brain fingerprint” remain distinct even during Alzheimer’s disease (AD)? Using fMRI data from healthy and pathologically ageing subjects, we find that individ...
Alzheimer's diseaseNetwork models
10.1038/S42003-024-06829-8
ISSN:2399-3642
Genetic architectures of cerebral ventricles and their overlap with neuropsychiatric traits
Yi-Jun Ge•Bang-Sheng Wu•Yi Zhang•Shi-Dong Chen•Ya-Ru Zhang等 43 人
Nature Human Behaviour
2023
•2023/10/19
•00 p.1-17
The cerebral ventricles are recognized as windows into brain development and disease, yet their genetic architectures, underlying neural mechanisms and utility in maintaining brain health remain elusive. Here we aggregated genetic and neuroimaging data from 61,974 participants (age range, 9 to 98 ye...
Alzheimer's diseaseGenetics of the nervous systemGenetics researchGenome-wide association studies
10.1038/S41562-023-01722-6
ISSN:2397-3374
Automated Alzheimer’s disease detection using active learning model with reinforcement learning and scope loss function
Zhisen He•Vijay Govindarajan•Jing Yang•Mahmoud Abdel-Salam•Zaffar Ahmed Shaikh等 9 人
Npj Mental Health Research
2025
•2025/10/8
•Vol.4 No.1 p.1-18
Alzheimer’s disease (AD) is a chronic, incurable brain disorder, and early detection is essential for effective management. Traditional detection methods often rely on large, pre-labeled image datasets, which are costly and difficult to compile. To address this, we propose an innovative active learn...
AnatomyMathematics and computingNeurologyNeuroscience
10.1038/S44184-025-00158-2
ISSN:2731-4251
White matter dysfunction in Alzheimer’s disease is associated with disease-related transcriptomic signatures
Yilu Li•Guanyu Zhou•Jinzhong Peng•Lin Liu•Fanyu Zhang等 9 人
Communications Biology
2025
•2025/5/28
•Vol.8 No.1 p.1-14
While anatomical white matter (WM) alterations in Alzheimer’s disease (AD) are well-established, functional WM dysregulation remains rarely investigated. The current study examines WM functional connectivity and network properties alterations in AD and mild cognitive impairment (MCI) and further des...
Alzheimer's diseaseDiagnostic markers
10.1038/S42003-025-08177-7
ISSN:2399-3642
Cerebrospinal fluid proteomic signatures in cognitively normal individuals identify distinct clusters linked to neurodegeneration
Dahun Seo•Anh N. Do•Gyujin Heo•Jiseon Kwon•Soomin Song等 23 人
Nature Aging
2025
•2025/10/14
•Vol.5 No.10 p.2125-2141
Age and APOE ε4 are major risk factors for Alzheimer’s disease (AD), while sex differences exist in disease prevalence and progression. Cerebrospinal fluid (CSF) proteomics can provide additional insights into brain aging and AD. To examine proteomic changes due to age, sex and apolipoprotein E (APO...
Cognitive ageingNeurodegeneration
10.1038/S43587-025-00971-6
ISSN:2662-8465
Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts
Cacciaglia Raffaele•Salvadó Gemma•Molinuevo José Luis•Shekari Mahnaz•Falcon Carles等 15 人
Molecular Psychiatry
2022
•2022/3/2
•00 p.1-9
Amyloid (Aβ) pathology is the earliest detectable pathophysiological event along the Alzheimer’s continuum, which can be measured both in the cerebrospinal fluid (CSF) and by Positron Emission Tomography (PET). Yet, these biomarkers identify two distinct Aβ pools, reflecting the clearance of soluble...
BiomarkersGeneticsNeuroscience
10.1038/S41380-022-01436-7
ISSN:1359-4184
Resting-state global brain activity affects early β-amyloid accumulation in default mode network
Feng Han•Xufu Liu•Richard B. Mailman•Xuemei Huang•Xiao Liu
Nature Communications
2023
•2023/11/27
•Vol.14 No.1 p.1-13
It remains unclear why β-amyloid (Aβ) plaque, a hallmark pathology of Alzheimer’s disease (AD), first accumulates cortically in the default mode network (DMN), years before AD diagnosis. Resting-state low-frequency ( < 0.1 Hz) global brain activity recently was linked to AD, presumably due to its...
Alzheimer's diseaseNeural circuits
10.1038/S41467-023-43627-Y
ISSN:2041-1723
Reevaluating the role of education on cognitive decline and brain aging in longitudinal cohorts across 33 Western countries
Anders M. Fjell•Ole Rogeberg•Øystein Sørensen•Inge K. Amlien•David Bartrés-Faz等 23 人
Nature Medicine
2025
•2025/7/28
•00 p.1-10
Why education is linked to higher cognitive function in aging is fiercely debated. Leading theories propose that education reduces brain decline in aging and enhances tolerance to brain pathology or that it does not affect cognitive decline but, rather, reflects higher early-life cognitive function....
Alzheimer's diseasePsychology
10.1038/S41591-025-03828-Y
ISSN:1078-8956
Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
Jacob W. Vogel•Yasser Iturria-Medina•Olof T. Strandberg•Ruben Smith•Elizabeth Levitis等 7 人
Nature Communications
2020
•2020/5/26
•Vol.11 No.1 p.1-15
Tau is a hallmark pathology of Alzheimer’s disease, and animal models have suggested that tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (Aβ). We test this hypothesis in humans using an epidemic spreading model (ESM) to simulate tau spread, and compare these sim...
Alzheimer's diseaseNetwork models
10.1038/S41467-020-15701-2
ISSN:2041-1723
Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank
Tiago Azevedo•Richard A. I. Bethlehem•David J. Whiteside•Nol Swaddiwudhipong•James B. Rowe等 7 人
Communications Medicine
2023
•2023/7/20
•Vol.3 No.1 p.1-15
Identifying prediagnostic neurodegenerative disease is a critical issue in neurodegenerative disease research, and Alzheimer’s disease (AD) in particular, to identify populations suitable for preventive and early disease-modifying trials. Evidence from genetic and other studies suggests the neurodeg...
BiomarkersNeuroscience
10.1038/S43856-023-00313-W
ISSN:2730-664X
Functional network collapse in neurodegenerative disease
Jesse A. Brown•Alex J. Lee•Kristen Fernhoff•Taylor Pistone•Lorenzo Pasquini等 17 人
Nature Communications
2025
•2025/11/21
•Vol.16 No.1 p.102730
Cognitive and behavioral deficits in Alzheimer’s disease (AD) and frontotemporal dementia (FTD) arise alongside gray matter atrophy and altered functional connectivity, yet the structure-function relationship across the dementia spectrum remains unclear. Here we combine structural and functional MRI...
Dynamical systemsNeurodegeneration
10.1038/S41467-025-65156-6
ISSN:2041-1723
Data-driven causal model discovery and personalized prediction in Alzheimer's disease
Zheng Haoyang•Petrella Jeffrey R.•Doraiswamy P. Murali•Lin Guang•Hao Wenrui
Npj Digital Medicine
2022
•2022/9/8
•Vol.5 No.1 p.1-12
With the explosive growth of biomarker data in Alzheimer’s disease (AD) clinical trials, numerous mathematical models have been developed to characterize disease-relevant biomarker trajectories over time. While some of these models are purely empiric, others are causal, built upon various hypotheses...
Computational modelsData processing
10.1038/S41746-022-00632-7
ISSN:2398-6352
Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease
Duong Michael Tran•Das Sandhitsu R.•Lyu Xueying•Xie Long•Richardson Hayley等 9 人
Nature Communications
2022
•2022/3/21
•Vol.13 No.1 p.1-15
Alzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in 18F-flortaucipir...
Alzheimer's diseaseNeurodegenerationPrognostic markers
10.1038/S41467-022-28941-1
ISSN:2041-1723
Predicting onset of symptomatic Alzheimerʼs disease with plasma p-tau217 clocks
Kellen K. Petersen•Marta Milà-Alomà•Yan Li•Lianlian Du•Chengjie Xiong等 30 人
Nature Medicine
2026
•2026/2/19
•Vol.32 No.3 p.1085-1094
Predicting not just if, but also when, cognitively unimpaired individuals are likely to develop onset of Alzheimerʼs disease (AD) symptoms would be useful to clinical trials and, eventually, clinical practice. Although clock models based on amyloid and tau positron emission tomography have shown pro...
Alzheimer's disease
10.1038/S41591-026-04206-Y
ISSN:1078-8956
A generalizable foundation model for analysis of human brain MRI
Divyanshu Tak•Biniam A. Garomsa•Anna Zapaishchykova•Tafadzwa L. Chaunzwa•Juan Carlos Climent Pardo等 25 人
Nature Neuroscience
2026
•2026/2/5
•Vol.29 No.4 p.945-956
Artificial intelligence applied to brain magnetic resonance imaging (MRI) holds potential to advance diagnosis, prognosis and treatment planning for neurological diseases. The field has been constrained, thus far, by limited training data and task-specific models that do not generalize well across p...
CNS cancerDiagnostic markers
10.1038/S41593-026-02202-6
ISSN:1097-6256
Plasma neurofilament light reflects more severe manifestation of Alzheimer’s disease in men
Xiaoqin Cheng•Zhenghong Wang•Kun He•Yingfeng Xia•Ying Wang等 8 人
Molecular Psychiatry
2025
•2025/8/12
•00 p.1-10
Plasma neurofilament light (NfL) protein is a promising non-invasive biomarker for detecting neuronal damage in Alzheimer’s disease (AD). However, its clinical utility is limited by the lack of standardized threshold values. Sex is an important factor that should be considered when setting these thr...
NeurosciencePrognostic markers
10.1038/S41380-025-03149-Z
ISSN:1359-4184
Cross-tissue analysis of blood and brain epigenome-wide association studies in Alzheimer’s disease
C. Silva Tiago•Young Juan I.•Zhang Lanyu•Gomez Lissette•Schmidt Michael A.等 9 人
Nature Communications
2022
•2022/8/18
•Vol.13 No.1 p.1-16
To better understand DNA methylation in Alzheimer’s disease (AD) from both mechanistic and biomarker perspectives, we performed an epigenome-wide meta-analysis of blood DNA methylation in two large independent blood-based studies in AD, the ADNI and AIBL studies, and identified 5 CpGs, mapped to the...
Alzheimer's diseaseDementiaDiagnostic markersDNA methylation
10.1038/S41467-022-32475-X
ISSN:2041-1723
Biomarker-integrated prognostic stagings for Alzheimer’s Disease
Daeun Shin•Sungjoo Lee•Jun Pyo Kim•Hyemin Jang•Jihwan Yun等 23 人
Nature Communications
2026
•2026/2/2
•Vol.17 No.1 p.22350
Accurately predicting disease progression remains a major challenge in Alzheimer’s disease (AD). Here we show that a biomarker-integrated prognostic staging system can stratify progression risk across the disease course by jointly incorporating cognitive status, established risk factors, plasma biom...
Alzheimer's diseasePrognostic markers
10.1038/S41467-026-68732-6
ISSN:2041-1723
Brain age gap as a predictive biomarker that links aging, lifestyle, and neuropsychiatric health
Ruixia Zhang•Fan Yi•Hongjing Mao•Zhengxing Huang•Kai Wang等 6 人
Communications Medicine
2025
•2025/10/24
•Vol.5 No.1 p.1-14
The brain age gap (BAG) is a neuroimaging-derived marker of accelerated brain aging. However, its clinical application faces challenges due to model inaccuracies and unclear links to disease mechanisms. This study investigates the clinical relevance of BAG across neuropsychiatric disorders, cognitiv...
Cognitive neuroscienceNeuroscience
10.1038/S43856-025-01100-5
ISSN:2730-664X
Common and rare variant analyses implicate JARID2 in cerebral tau deposition
Tamil Iniyan Gunasekaran•Devendra Meena•Annie J. Lee•Siwei Wu•Logan Dumitrescu等 12 人
Npj Dementia
2026
•2026/7/3
•Vol.2 No.1 p.520
Genetic research on Alzheimer’s disease (AD) has primarily focused on amyloid-β (Aβ), with fewer studies exploring tau pathology. We performed common variant GWAS on tau-PET SUVRs from A4 (n = 311 preclinical AD) and ADNI (n = 375 across diagnostic groups) cohorts. We complemented this with locus-sp...
DiseasesGeneticsNeurologyNeuroscience
10.1038/S44400-026-00107-6
ISSN:3005-1940
A longitudinal DNA methylation atlas and its link to brain structure and mental health
Di Chen•Xinyang Yu•Wei Cheng•Linbo Wang•Shitong Xiang等 34 人
Molecular Psychiatry
2026
•2026/3/31
•00 p.1-15
Epigenetic mechanisms are thought to contribute to neurodevelopmental vulnerability for psychiatric disorders, yet longitudinal evidence linking DNA methylation (DNAm) to brain maturation and psychopathology is limited. Using epigenome-wide DNAm (372,582 CpGs) and whole-brain structural MRI data fro...
GeneticsPsychiatric disorders
10.1038/S41380-026-03554-Y
ISSN:1359-4184