The HBCC Postmortem Psychiatric Molecular Studies dataset is a collection of genetic and molecular data derived from post-mortem brain tissues of individuals with psychiatric disorders. The study focuses on identifying molecular signatures associated with mental health conditions such as schizophrenia, bipolar disorder, major depressive disorder, and others. Brain tissue samples are collected under strict protocols with IRB approval, ensuring ethical handling of materials provided by next-of-kin consent. The dataset includes DNA extracted from cerebellar tissue, genotyped using Illumina Beadarray chips, RNA expression data from hippocampus, dorsolateral prefrontal cortex (DLPFC), and dura mater regions, as well as RNA-seq datasets for DLPFC and subgenual anterior cingulate cortex (sgACC). The study aims to advance understanding of the molecular mechanisms underlying psychiatric disorders by analyzing genetic variations, gene expression, and other molecular profiles across diverse brain regions in individuals with these conditions. Over 468 brains have been dissected into various regions for this purpose.