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Chinese
China, Wenzhou
YANGLAB

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页面调试行为已被阻止

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相关论文

8

Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation

Zhenbin LuWenhan Shi
Translational Psychiatry
2026
2026/3/30
Vol.16 No.1 p.2150
Bisphenol A (BPA) is a widely used endocrine-disrupting chemical that has been implicated in neurodevelopmental and psychiatric disorders; however, the molecular mechanisms linking BPA exposure to major depressive disorder (MDD) remain poorly understood. In this study, we systematically investigated...
DepressionScientific community
10.1038/S41398-026-03862-5
ISSN:2158-3188

Age-specific childhood obesity and adult cholelithiasis: association and shared transcriptomic bases

Lihua LiuLu ZhangYiwen LiaoXin JinYunzhu Chen12
International Journal Of Obesity
2025
2025/8/22
00 p.1-8
The association between obesity and cholelithiasis has been identified. However, the causal relationship between age-specific childhood obesity and adult cholelithiasis remains unclear. In addition, the biological basis for the association between childhood obesity and adult cholelithiasis is poorly...
EpidemiologyRisk factors
10.1038/S41366-025-01877-4
ISSN:0307-0565

Genome-wide associations of structural variants with human traits through imputation from long-read assemblies

Wei-Yang BaiShuli LiuZhongqu DuanJi-Jian YangJie Chen10
Nature Genetics
2026
2026/5/20
00 p.1-10
Structural variants (SVs) are a major type of genetic variation, yet their role in human traits remains largely uncharacterized, primarily due to challenges in genotyping them on a genome-wide scale in large cohorts. Here we identified 171,233 high-quality, genome-wide SVs from 482 haplotype-resolve...
Genome-wide association studiesGenomics
10.1038/S41588-026-02612-Z
ISSN:1061-4036

Cross-ancestry pleiotropic analysis of imaging-derived phenotypes enhances risk stratification of depression

Yu FengXiaonan GuoPeng HuangNingning JiaShaohua Hu6
Molecular Psychiatry
2026
2026/7/1
00 p.1-15
Depression arises from dynamic interactions among genetic predisposition, brain alterations, and environmental stressors. Despite genome-wide association studies (GWAS) identifying risk loci, the mechanisms translating genetic variation into brain changes remain elusive. Imaging-derived phenotypes (...
DepressionGenetics
10.1038/S41380-026-03730-0
ISSN:1359-4184

Multi-ancestry GWAS of age-related hearing loss identifies 140 loci and key cellular mechanisms

Lulu ShiHaibin HeJunpeng LiKai GaiWenjian Li8
Nature Communications
2026
2026/2/21
0
Age-related hearing loss is a prevalent and growing public health issue among the elderly. Here, we perform a multi-ancestry genome-wide association study comprising 456,613 cases and 1,053,834 controls, identifying 140 independent loci associated with age-related hearing loss, including 44 novel si...
Genome-wide association studiesInner earPredictive markers
10.1038/S41467-026-69894-Z
ISSN:2041-1723

The 1000 Chinese Pangenome empowers medical and population genetics

Yifei WangZhongqu DuanDan ChenDandan ShiYi Ding21
Nature
2026
2026/4/1
00 p.1-10
Pangenomes are revolutionizing our ability to resolve genomic regions with complex variations1. However, existing human pangenomes2,3, constrained by small sample sizes, provide limited utility for medical and population genetic applications. Here we generated 1,116 diploid genome assemblies (55 de ...
Genetic association studyGenetic variationGenome assembly algorithmsSequencingStructural variation
10.1038/S41586-026-10315-Y
ISSN:0028-0836

Cross-ancestry genetic architecture reveals shared biological pathways of major psychiatric disorders

Yu FengNingning JiaPeng HuangShaohua HuSheng Yang
Molecular Psychiatry
2026
2026/3/17
00 p.1-13
Psychiatric disorders, including bipolar disorder (BD), major depressive disorder (MDD), and schizophrenia (SCZ), share substantial genetic overlap. We conducted a cross-ancestry multivariate genome-wide association study (GWAS) integrating European and East Asian populations to uncover shared genet...
BiomarkersGeneticsPsychiatric disorders
10.1038/S41380-026-03541-3
ISSN:1359-4184

Multi-ancestry genome-wide association analyses of refractive error augment genetic discovery and polygenic prediction

Fei-Fei ChengXiaoxi LiuHao MiLizhong WangRuilei Ma27
Nature Genetics
2026
2026/4/20
00 p.1-10
Refractive errors (REs) affect over half of the global population, with consequences ranging from blurred vision to blindness. Here we conducted ancestry-stratified and cross-ancestry meta-analyses of genome-wide association studies for RE in people of European (n = 1,495,159), East Asian (n = 121,1...
DiseasesGenome-wide association studies
10.1038/S41588-026-02576-0
ISSN:1061-4036