Extensive binding of uncharacterized human transcription factors to genomic dark matter
Arttu Jolma
2024
2024/11/11
United States, Cabin John
University of Toronto
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1Homo sapiens
www.ncbi.nlm.nih.gov
IP: 130.14.29.110
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相关论文
1An expanded codebook of human transcription factor DNA-binding specificity
Arttu Jolma•Kaitlin U. Laverty•Ali Fathi•Ally W. H. Yang•Isaac Yellan等 29 人
Nature
2026
•2026/8/5
•00 p.1-9
Gene expression is regulated by transcription factors (TFs), which recognize specific DNA sequence motifs. Several hundred putative human TFs, identified mainly by an apparent DNA-binding domain, lack known binding motifs1. Furthermore, even for well-characterized TFs, it remains controversial the d...
Gene regulationTranscriptional regulatory elementsTranscriptomics
10.1038/S41586-026-10798-9
ISSN:0028-0836