Genes & Health is a not-for-profit research dataset linking participant-level genetic data with phenotype information and electronic health records, including NHS health data and custom-curated phenotypes. It supports approved studies through a secure Trusted Research Environment, where researchers can analyse these linked health and genomic data without downloading identifiable participant information. The resource is designed to enable high-quality research on disease risk, biology, and population health, with particular emphasis on diabetes, cardiovascular disease, mental health, and cancer, while also supporting recall studies that involve minimal-risk collection of small blood or urine samples for scientifically valuable follow-up investigations.