CD169+ Macrophages Identify and Eliminate Tumor Cells in Colorectal Cancer through CD169/CD43 Interaction and FasL-Driven Apoptosis
English
China, Beijing
Nankai University
数据描述
iProX is an integrated proteome resource center designed to accelerate global proteomics data sharing. It operates under the ProteomeXchange Consortium, assigning PXD identifiers to submitted datasets, which become public upon publication. The platform accommodates both public and private submissions through a web-based system, with registered users contributing raw data, metadata, protein identifications, and more. Currently, iProX hosts 7169 projects and 10734 subprojects, encompassing over 705,000 data files. Recent contributions include studies on tumor cell elimination mechanisms, viral protein interactions, and plant drought tolerance, reflecting its diverse application in advancing proteomics research worldwide.
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2026
•2026/1/8
•00 p.1-22
Profiling molecular panorama from massive omics data identifies regulatory networks in cells but requires mechanistic interpretation and experimental follow up. Here we combine deep learning and large language model reasoning to develop a hybrid workflow for omics interpretation, called LyMOI. LyMOI...
AutophagyBioinformaticsData miningMachine learningTargeted therapies
10.1038/S41551-025-01576-5
ISSN:2157-846X
Plasma proteome profiling reveals dynamic of cholesterol marker after dual blocker therapy
Jiacheng Lyu•Lin Bai•Yumiao Li•Xiaofang Wang•Zeya Xu等 15 人
Nature Communications
2024
•2024/5/8
•Vol.15 No.1 p.1-14
Dual blocker therapy (DBT) has the enhanced antitumor benefits than the monotherapy. Yet, few effective biomarkers are developed to monitor the therapy response. Herein, we investigate the DBT longitudinal plasma proteome profiling including 113 longitudinal samples from 22 patients who received ant...
Cancer immunotherapyPredictive markersProteome informatics
10.1038/S41467-024-47835-Y
ISSN:2041-1723
StrucGAP: a modular, streamlined and traceable data mining platform for structural and site-specific glycoproteomics
Muyao Yang•Yongqi Wu•Zhida Zhang•Yongchao Xu•Tianjia Lei等 10 人
Nature Communications
2026
•2026/3/19
•Vol.17 No.1 p.25790
The rapidly developing search engines for glycopeptide identification and accumulated high-resolution glycoproteomic data underscore the need for robust downstream data mining platforms towards subsequently functional and mechanistic studies. Here, we introduce StrucGAP, a Structural Glycoproteomics...
GlycomicsGlycosylation
10.1038/S41467-026-70560-7
ISSN:2041-1723
Targeting Smurf1 to block PDK1–Akt signaling in KRAS-mutated colorectal cancer
Zhiqiang Peng•Wei Fang•Bo Wu•Ming He•Shaohua Li等 21 人
Nature Chemical Biology
2024
•2024/7/22
•00 p.1-12
The phosphoinositide 3-kinase (PI3K)–Akt axis is one of the most frequently activated pathways and is demonstrated as a therapeutic target in Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutated colorectal cancer (CRC). Targeting the PI3K–Akt pathway has been a challenging undertaking through t...
Cancer therapyCell signallingKinasesPost-translational modificationsSmall molecules
10.1038/S41589-024-01683-5
ISSN:1552-4450
Molecular classification of hormone receptor-positive HER2-negative breast cancer
Xi Jin•Yi-Fan Zhou•Ding Ma•Shen Zhao•Cai-Jin Lin等 19 人
Nature Genetics
2023
•2023/9/28
•00 p.1-13
Hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2−) breast cancer is the most prevalent type of breast cancer, in which endocrine therapy resistance and distant relapse remain unmet challenges. Accurate molecular classification is urgently required for guiding p...
Breast cancerTranslational research
10.1038/S41588-023-01507-7
ISSN:1061-4036
Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling
Ying Cheng•Man Zhang•Chenguang Li•Long Su•Lingli Fu等 9 人
Nature Communications
2025
•2025/2/4
•Vol.16 No.1 p.1-17
Abnormal angiogenesis is a key process associated with ischaemic retinopathies such as diabetic retinopathy, for which the underlying pathological mechanisms are still poorly understood. Here, we confirm that angiogenic factor 1 with a G patch and FHA domain (AGGF1) is elevated in the diabetics and ...
AngiogenesisCell proliferation
10.1038/S41467-025-55970-3
ISSN:2041-1723
Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis
Hongyun Zhang•Bobo Zhang•Yuebo Zhao•Yang Su•Yifan Peng等 23 人
Nature Chemical Biology
2025
•2025/8/26
•00 p.1-14
E-cadherin downregulation is an epithelial–mesenchymal transition hallmark canonically attributed to transcriptional repression. Here we delineate a metabolite-driven endocytic route of E-cadherin downregulation in inflammation-associated colorectal cancer (CRC). Specifically, IP6 kinase-2 (IP6K2), ...
CancerCell signallingKinasesMembrane traffickingPost-translational modifications
10.1038/S41589-025-02005-Z
ISSN:1552-4450
Small protein ERSP encoded by LINC02870 promotes triple negative breast cancer progression via IRE1α/XBP1s activation
Xiaolu Wang•Qianqian Wang•Hong Wang•Guodi Cai•Yana An等 11 人
Cell Death & Differentiation
2025
•2025/1/11
•00 p.1-12
Clinical treatment options for triple-negative breast cancer (TNBC) are currently limited to chemotherapy because of a lack of effective therapeutic targets. Recent evidence suggests that long noncoding RNAs (lncRNAs) encode bioactive peptides or proteins, thereby playing noncanonical yet significan...
ER-associated degradationMetastasisOncogenes
10.1038/S41418-025-01443-5
ISSN:1350-9047
Longitudinal plasma proteome profiling reveals the diversity of biomarkers for diagnosis and cetuximab therapy response of colorectal cancer
Yan Li•Bing Wang•Wentao Yang•Fahan Ma•Jianling Zou等 12 人
Nature Communications
2024
•2024/2/1
•Vol.15 No.1 p.1-23
Cetuximab therapy is the major treatment for colorectal cancer (CRC), but drug resistance limits its effectiveness. Here, we perform longitudinal and deep proteomic profiling of 641 plasma samples originated from 147 CRC patients (CRCs) undergoing cetuximab therapy with multi-course treatment, and 9...
Colorectal cancerTargeted therapies
10.1038/S41467-024-44911-1
ISSN:2041-1723
Cancer biomarkers discovered using pan-cancer plasma proteomic profiling
Lin Bai•Jiacheng Lyu•Jinwen Feng•Xiaoqiang Qiao•Yuanyuan Qu等 37 人
Nature Biomedical Engineering
2025
•2025/7/2
•00 p.1-23
Mass-spectrometry-based proteomic data of tumour patient plasma samples present opportunities for improving cancer detection. Here we generate plasma proteomic profiles from 2,251 pan-cancer patient samples and investigate potential diagnostic biomarkers. Proteomic subtyping with different dominant ...
Tumour biomarkersTumour heterogeneity
10.1038/S41551-025-01448-Y
ISSN:2157-846X
A proteogenomic analysis of clear cell renal cell carcinoma in a Chinese population
Qu Yuanyuan•Feng Jinwen•Wu Xiaohui•Bai Lin•Xu Wenhao等 25 人
Nature Communications
2022
•2022/4/19
•Vol.13 No.1 p.1-21
Clear cell renal cell carcinoma (ccRCC) is a common and aggressive subtype of renal cancer. Here we conduct a comprehensive proteogenomic analysis of 232 tumor and adjacent non-tumor tissue pairs from Chinese ccRCC patients. By comparing with tumor adjacent tissues, we find that ccRCC shows extensiv...
ProteomicsTumour heterogeneityUrological cancer
10.1038/S41467-022-29577-X
ISSN:2041-1723
Dynamic landscape mapping of humoral immunity to SARS-CoV-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients
Cheng Linlin•Zhang Xiaomei•Chen Yu•Wang Dan•Zhang Dong等 30 人
Signal Transduction And Targeted Therapy
2021
•2021/8/17
•Vol.6 No.1 p.1-14
A comprehensive analysis of the humoral immune response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is essential in understanding COVID-19 pathogenesis and developing antibody-based diagnostics and therapy. In this work, we performed a longitudinal analysis of antibody respon...
Infectious diseases
10.1038/S41392-021-00718-W
ISSN:2059-3635
O-GlcNAcylation of PFKFB3 is required for tumor cell proliferation under hypoxia
Yinrui Lei•Tao Chen•Yeyi Li•Man Shang•Yan Zhang等 9 人
Oncogenesis
2020
•2020/2/14
•Vol.9 No.2 p.1-12
The protein O-GlcNAcylation catalysed by O-GlcNAc transferase (OGT) is tightly regulated by glucose availability. It is upregulated and essential for tumor cell proliferation under hypoxic conditions. However, the mechanism behind is still unclear. Here, we showed that the glycolytic regulator 6-pho...
Cancer metabolismGlycosylation
10.1038/S41389-020-0208-1
ISSN:2157-9024
Enhanced inflammation and suppressed adaptive immunity in COVID-19 with prolonged RNA shedding
Tang Xiaohua•Sun Rui•Ge Weigang•Mao Tingting•Qian Liujia等 32 人
Cell Discovery
2022
•2022/7/25
•Vol.8 No.1 p.1-18
Little is known regarding why a subset of COVID-19 patients exhibited prolonged positivity of SARS-CoV-2 infection. Here, we found that patients with long viral RNA course (LC) exhibited prolonged high-level IgG antibodies and higher regulatory T (Treg) cell counts compared to those with short viral...
Innate immunityProteomics
10.1038/S41421-022-00441-Y
ISSN:2056-5968
Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis
Ping Liu•Xiaoji Cong•Shengjie Liao•Xinglong Jia•Xiaomin Wang等 18 人
Cell Death & Differentiation
2021
•2021/7/2
•00 p.1-13
SKP1-CUL1-F-box (SCF) ubiquitin ligases play fundamental roles in cellular functions. Typically, substrate phosphorylation is required for SCF recognition and subsequent degradation. However, phospho-dependent substrates remain largely unidentified. Here, using quantitative phoshoproteome approach, ...
ProteomicsUbiquitylation
10.1038/S41418-021-00827-7
ISSN:1350-9047
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma
Ying Jiang•Aihua Sun•Yang Zhao•Wantao Ying•Huichuan Sun等 38 人
Nature
2019
•2019/2/27
•Vol.567 No.7747 p.257-261
Hepatocellular carcinoma is the third leading cause of deaths from cancer worldwide. Infection with the hepatitis B virus is one of the leading risk factors for developing hepatocellular carcinoma, particularly in East Asia1. Although surgical treatment may be effective in the early stages, the five...
Liver cancerProteomics
10.1038/S41586-019-0987-8
ISSN:0028-0836
Endoplasmic reticulum stress-induced histone lactylation mediating immune escape of gastric cancer via PDIA6 overexpression in dendritic cells
Chengshu Tu•Ziqing Wu•Xuxian Zhong•Shengnan Yang•Xi Chen等 8 人
Cell Death & Disease
2026
•2026/3/27
0Gastric cancer is one of the most prevalent cancers worldwide and is associated with a high mortality rate. Although immunotherapy has achieved some success for many tumor types, the limited response of gastric cancer to immunotherapy poses a challenge. Lactylation is a recently proposed post-transl...
CancerImmunologyMedical research
10.1038/S41419-026-08638-9
ISSN:2041-4889
Plastoglobules compartmentalize nitrogen assimilation in maize
Di Chen•Lulu Gao•Shujun Li•Yiqiu Cheng•Xiaoxian Wu等 26 人
Nature
2026
•2026/6/3
•00 p.1-12
Efficient nitrogen assimilation is important for sustainable agriculture1, yet its subcellular organization remains unknown. Here we show that plastoglobules (PGs) in the chloroplasts of mesophyll cells function as a metabolic hub that orchestrates nitrogen utilization in maize. Nitrogen-responsive ...
AgricultureChloroplastsPlant genetics
10.1038/S41586-026-10610-8
ISSN:0028-0836
SOCS5-RBMX stimulates SREBP1-mediated lipogenesis to promote metastasis in steatotic HCC with HBV-related cirrhosis
Youpeng Wang•Ziyin Zhao•Tingting Guo•Tiansong Wu•Mao Zhang等 12 人
Npj Precision Oncology
2024
•2024/3/1
•Vol.8 No.1 p.1-16
Abnormal lipid metabolism promotes hepatocellular carcinoma (HCC) progression, which engenders therapeutic difficulties owing to unclear mechanisms of the phenomenon. We precisely described a special steatotic HCC subtype with HBV-related cirrhosis and probed its drivers. Hematoxylin-eosin (HE) stai...
Cancer metabolismHepatocellular carcinomaOncogenes
10.1038/S41698-024-00545-6
ISSN:2397-768X
Branched-chain amino acid transaminase 1 confers EGFR-TKI resistance through epigenetic glycolytic activation
Tao Zhang•Zilu Pan•Jing Gao•Qingqing Wu•Gang Bai等 28 人
Signal Transduction And Targeted Therapy
2024
•2024/8/15
•Vol.9 No.1 p.1-17
Third-generation EGFR tyrosine kinase inhibitors (TKIs), exemplified by osimertinib, have demonstrated promising clinical efficacy in the treatment of non-small cell lung cancer (NSCLC). Our previous work has identified ASK120067 as a novel third-generation EGFR TKI with remarkable antitumor effects...
Cancer metabolismLung cancer
10.1038/S41392-024-01928-8
ISSN:2059-3635
Dual-resolving of positional and geometric isomers of C=C bonds via bifunctional photocycloaddition-photoisomerization reaction system
Feng Guifang•Gao Ming•Wang Liwei•Chen Jiayi•Hou Menglu等 10 人
Nature Communications
2022
•2022/5/12
•Vol.13 No.1 p.1-12
The biological functions of lipids largely depend on their chemical structures. The position and configuration of C=C bonds are two of the essential attributes that determine the structures of unsaturated lipids. However, simultaneous identification of both attributes remains challenging. Here, we d...
Chemical toolsLipidomicsMass spectrometry
10.1038/S41467-022-30249-Z
ISSN:2041-1723
Decoding the mechanical characteristics of the human anterior cruciate ligament entheses through graduated mineralization interfaces
Jinghua Fang•Xiaozhao Wang•Huinan Lai•Wenyue Li•Xudong Yao等 21 人
Nature Communications
2024
•2024/10/26
•Vol.15 No.1 p.1-14
The anterior cruciate ligament is anchored to the femur and tibia via specialized interfaces known as entheses. These play a critical role in ligament homeostasis and joint stability by transferring forces, varying in magnitude and direction between structurally and functionally dissimilar tissues. ...
Biomedical engineeringBiomedical materialsBiomineralizationBoneOrganic–inorganic nanostructures
10.1038/S41467-024-53542-5
ISSN:2041-1723
Recycling senescent cell lipids for targeted senotherapy
Xiaoxiao Ji•Xingzi He•Honglu Cai•Peng Tang•Hao Zhou等 19 人
Nature Communications
2026
•2026/3/13
0Senescent cells (SnCs) are increasingly recognized as key contributors to osteoarthritis, with conventional strategies centered on their elimination. However, senolytic approaches face mounting limitations, driving the need for refined interventions. Here, we exploit SnCs’ lipid metabolic signature ...
Biomedical materialsNanoparticlesSenescence
10.1038/S41467-026-70486-0
ISSN:2041-1723
Bacteroides fragilis toxin promotes gall bladder cancer in mice
Jun Chen•Yang An•Aiyanlun Tong•Siyuan Kang•Zisong Xu等 11 人
Nature Microbiology
2026
•2026/6/25
•00 p.1-18
Enterotoxigenic Bacteroides fragilis (ETBF), which secretes B. fragilis toxin (BFT) and has been associated with colorectal cancer, can be enriched in patients with gall bladder cancer (GBC). Whether and how ETBF contributes to GBC is unclear. Here we confirm, through analysis of patient samples, th...
Bacterial host responseCancer
10.1038/S41564-026-02404-5
ISSN:2058-5276
HuB serves as the central hub for connecting HuR-related mRNAs with translation machinery in inflammation
Jing Zhang•Ximan Huang•Yunhan Tang•Xiyue Zhong•Jing Wang等 9 人
Communications Biology
2025
•2025/11/30
0The mRNAs of inflammatory factors often contain unstable AU-rich elements (AREs) within their 3’ untranslated regions (3’UTRs), and HuR is a key ARE-binding protein to recognize such elements. However, the roles of other Hu family member (s) remain unclear. In this study, we show an inflammatory sti...
RibosomeRNA decayStress signalling
10.1038/S42003-025-09228-9
ISSN:2399-3642
Sabinineoside B alleviates metabolic dysfunction-associated steatotic liver disease by targeting PPAR α
Yan Feng•Renhao Chen•Yiming Li•Yilei Wang•Yuwei Wang等 9 人
Communications Biology
2026
•2026/4/21
0With the rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), the development of new drugs targeting this condition is particularly urgent. Sabinineoside B, a new compound of phenanthrene alkaloid glycoside isolated from the traditional Chinese herb Sabia parviflora...
PharmacodynamicsTarget identification
10.1038/S42003-026-10082-6
ISSN:2399-3642
Allicin promotes functional recovery in ischemic stroke via glutathione peroxidase-1 activation of Src-Akt-Erk
Fei Zhuang•Xin Shi•Sen Qiao•Bin Liu•Zhimei Wang等 11 人
Cell Death Discovery
2023
•2023/9/6
•Vol.9 No.1 p.1-13
Allicin exhibits various pharmacological activities and has been suggested to be beneficial in the treatment of stroke. However, the underlying mechanisms are largely unknown. Here, we confirmed that allicin protected the brain from cerebral injury, which could be ascribed to its anti‑apoptotic and ...
AstrocyteMolecular neuroscience
10.1038/S41420-023-01633-5
ISSN:2058-7716
Pan-cancer proteogenomic investigations identify post-transcriptional kinase targets
Elmas Abdulkadir•Tharakan Serena•Jaladanki Suraj•Galsky Matthew D.•Liu Tao等 6 人
Communications Biology
2021
•2021/9/22
•Vol.4 No.1 p.1-13
Identifying genomic alterations of cancer proteins has guided the development of targeted therapies, but proteomic analyses are required to validate and reveal new treatment opportunities. Herein, we develop a new algorithm, OPPTI, to discover overexpressed kinase proteins across 10 cancer types usi...
Cancer genomicsProteome informatics
10.1038/S42003-021-02636-7
ISSN:2399-3642
DDX5 inhibits hyaline cartilage fibrosis and degradation in osteoarthritis via alternative splicing and G-quadruplex unwinding
Qianqian Liu•Mingrui Han•Zhigui Wu•Wenqiang Fu•Jun Ji等 15 人
Nature Aging
2024
•2024/5/17
•Vol.4 No.5 p.664-680
Hyaline cartilage fibrosis is typically considered an end-stage pathology of osteoarthritis (OA), which results in changes to the extracellular matrix. However, the mechanism behind this is largely unclear. Here, we found that the RNA helicase DDX5 was dramatically downregulated during the progressi...
AgeingProteomicsRNA splicingSolution-state NMR
10.1038/S43587-024-00624-0
ISSN:2662-8465
SARS-CoV-2 infection in the mouse olfactory system
Qing Ye•Jia Zhou•Qi He•Rui-Ting Li•Guan Yang等 19 人
Cell Discovery
2021
•2021/7/6
•Vol.7 No.1 p.1-13
SARS-CoV-2 infection causes a wide spectrum of clinical manifestations in humans, and olfactory dysfunction is one of the most predictive and common symptoms in COVID-19 patients. However, the underlying mechanism by which SARS-CoV-2 infection leads to olfactory disorders remains elusive. Herein, we...
Cell signallingMechanisms of disease
10.1038/S41421-021-00290-1
ISSN:2056-5968
An EGFR/HER2-targeted conjugate sensitizes gemcitabine-sensitive and resistant pancreatic cancer through different SMAD4-mediated mechanisms
Yao Hongjuan•Song Wenping•Cao Rui•Ye Cheng•Zhang Li等 14 人
Nature Communications
2022
•2022/9/20
•Vol.13 No.1 p.1-24
Chemoresistance limits its clinical implementation for pancreatic ductal adenocarcinoma (PDAC). We previously generated an EGFR/HER2 targeted conjugate, dual-targeting ligand-based lidamycin (DTLL), which shows a highly potent antitumor effect. To overcome chemoresistance in PDAC, we aim to study DT...
Cancer therapeutic resistanceDrug developmentTargeted therapies
10.1038/S41467-022-33037-X
ISSN:2041-1723