Adolescent Brain Cognitive Development (ABCD) Study Data Release 5.1
English
United States, Ashburn
NIMH Data Archive
数据描述
The ABCD Data Repository in the NIMH Data Archive houses data from the Adolescent Brain Cognitive Development (ABCD) Study, a prospective longitudinal cohort following nearly 12,000 diverse youth recruited at ages 9–10 across 21 U.S. research sites for 10 years. The dataset contains curated and tabulated behavioral, social, emotional, cognitive, mental health, substance use, gender identity/sexual health, physical health, biospecimen, and environmental measures, along with brain imaging data including structural MRI, task fMRI, and resting-state fMRI, plus minimally processed and FastTrack MRI and raw behavioral data. Linked external databases add contextual indicators such as local environment, poverty, pollution, school, and policy to support research on adolescent development.
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10.1038/S41562-024-01931-7
ISSN:2397-3374
The sex-specific role of adrenal androgens in youth psychopathology
Franka Edith Weisner•Bianca Serio•Sofie Valk•Luise Bläschke•Franziska Degenhardt等 8 人
Translational Psychiatry
2026
•2026/6/4
•Vol.16 No.1 p.3000
Adolescence is a vulnerable period for the emergence of mental health problems. Adrenarche, an early stage of pubertal development marked by rising adrenal androgens, particularly dehydroepiandrosterone (DHEA), may influence emotional and behavioral development. However, longitudinal evidence linkin...
Molecular neurosciencePredictive markersPsychiatric disorders
10.1038/S41398-026-04121-3
ISSN:2158-3188
Joint multi-ancestry and admixed GWAS reveals the complex genetics behind human cranial vault shape
Seppe Goovaerts•Hanne Hoskens•Ryan J. Eller•Noah Herrick•Anthony M. Musolf等 20 人
Nature Communications
2023
•2023/11/16
•Vol.14 No.1 p.1-21
The cranial vault in humans is highly variable, clinically relevant, and heritable, yet its genetic architecture remains poorly understood. Here, we conduct a joint multi-ancestry and admixed multivariate genome-wide association study on 3D cranial vault shape extracted from magnetic resonance image...
Genetics researchGenome-wide association studiesMagnetic resonance imagingQuantitative trait
10.1038/S41467-023-43237-8
ISSN:2041-1723
Functional brain network dynamics mediate the relationship between female reproductive aging and interpersonal adversity
Raluca Petrican•Sidhant Chopra•Ashlea Segal•Nick Fallon•Alex Fornito
Nature Mental Health
2025
•2025/1/7
•Vol.3 No.1 p.104-123
Premature reproductive aging is linked to heightened stress sensitivity and psychological maladjustment across the life course. However, the brain dynamics underlying this relationship are poorly understood. Here, to address this issue, we analyzed multimodal data from female participants in the Ado...
Molecular neuroscienceNeural ageing
10.1038/S44220-024-00352-9
ISSN:2731-6076
The association between latent trauma and brain structure in children
Hee Jung Jeong•E. Leighton Durham•Tyler M. Moore•Randolph M. Dupont•Malerie McDowell等 10 人
Translational Psychiatry
2021
•2021/4/24
•Vol.11 No.1 p.1-9
The developing brain is marked by high plasticity, which can lead to vulnerability to early life stressors. Previous studies indicate that childhood maltreatment is associated with structural aberrations across a number of brain regions. However, prior work is limited by small sample sizes, heteroge...
NeurosciencePsychology
10.1038/S41398-021-01357-Z
ISSN:2158-3188
Cognitive predictors of mental health trajectories are mediated by inferior frontal and occipital development during adolescence
Qingyang Li•Miao Cao•Dan J. Stein•Barbara J. Sahakian•Tianye Jia等 36 人
Molecular Psychiatry
2025
•2025/2/1
•00 p.1-14
Laboratory studies show brain maturation involves synaptic pruning and cognitive development. Human studies suggest links between early cognitive performance and later mental health, but inconsistencies remain. It is unclear if specific brain regions mediate this relationship, and the molecular unde...
Psychiatric disordersPsychology
10.1038/S41380-025-02912-6
ISSN:1359-4184
Genetic risk predicts adolescent mood pathology via sexual differentiation of brain function and physiological aging
Raluca Petrican•Alex Fornito•Christopher Murgatroyd•Emma Boyland•Charlotte A. Hardman
Nature Communications
2025
•2025/7/1
•Vol.16 No.1 p.1-21
Recent evidence challenged the traditional, categorical approach to sex differences, indicating that each human brain comprises a mosaic of features, some of which are more common among males, others, among females, whereas the remaining are equally common between sexes. Thus, a focus on regional se...
Feeding behaviourInflammationPersonality
10.1038/S41467-025-60686-5
ISSN:2041-1723
Associations of family income with cognition and brain structure in USA children: prevention implications
Dardo Tomasi•Nora D. Volkow
Molecular Psychiatry
2021
•2021/5/14
•00 p.1-11
Poverty, as assessed by several socioeconomic (SES) factors, has been linked to worse cognitive performance and reduced cortical brain volumes in children. However, the relative contributions of the various SES factors on brain development and the mediating effects between cognition and brain morpho...
NeurosciencePredictive markers
10.1038/S41380-021-01130-0
ISSN:1359-4184
Neuroimaging profiling identifies distinct brain maturational subtypes of youth with mood and anxiety disorders
Ge Ruiyang•Sassi Roberto•Yatham Lakshmi N.•Frangou Sophia
Molecular Psychiatry
2022
•2022/12/28
•Vol.28 No.3 p.1072-1078
Mood and anxiety disorders typically begin in adolescence and have overlapping clinical features but marked inter-individual variation in clinical presentation. The use of multimodal neuroimaging data may offer novel insights into the underlying brain mechanisms. We applied Heterogeneity Through Dis...
Bipolar disorderDepressionDiagnostic markers
10.1038/S41380-022-01925-9
ISSN:1359-4184
Towards a general-purpose foundation model for functional MRI analysis
Cheng Wang•Yu Jiang•Zhihao Peng•Chenxin Li•Chang-bae Bang等 21 人
Nature Biomedical Engineering
2026
•2026/4/23
•00 p.1-12
Functional magnetic resonance imaging (fMRI) is crucial for studying brain function and diagnosing neurological disorders. However, existing analysis methods suffer from reproducibility and transferability challenges due to complex preprocessing pipelines and task-specific model designs. Here we int...
Computational scienceMagnetic resonance imaging
10.1038/S41551-026-01666-Y
ISSN:2157-846X
Brain structure is linked to the association between family environment and behavioral problems in children in the ABCD study
Weikang Gong•Edmund T. Rolls•Jingnan Du•Jianfeng Feng•Wei Cheng
Nature Communications
2021
•2021/6/18
•Vol.12 No.1 p.1-10
Children’s behavioral problems have been associated with their family environments. Here, we investigate whether specific features of brain structures could relate to this link. Using structural magnetic resonance imaging of 8756 children aged 9-11 from the Adolescent Brain Cognitive Developmental s...
Cognitive neuroscienceNeuroscience
10.1038/S41467-021-23994-0
ISSN:2041-1723