RNA-seq of coding RNA from tissue samples of 122 human individuals representing 32 different tissues
Björn Hallström
2015
2015/1/13
United Kingdom, Cambridge
Science for Life Laboratory, Royal Institute of Technology, Stockholm
数据描述
RNA-seq was performed of tissue samples from 122 human individuals representing 32 different tissues in order to study the human tissue transcriptome. This submission contains 27 new samples and the data from E-MTAB-1733. This dataset is part of the TransQST collection.
学科分类
1RNA-seq of coding RNA
www.ebi.ac.uk
IP: 193.62.193.80
加载中...
相关论文
6Deep learning-driven fragment ion series classification enables highly precise and sensitive de novo peptide sequencing
Daniela Klaproth-Andrade•Johannes Hingerl•Yanik Bruns•Nicholas H. Smith•Jakob Träuble等 7 人
Nature Communications
2024
•2024/1/2
•Vol.15 No.1 p.1-14
Unlike for DNA and RNA, accurate and high-throughput sequencing methods for proteins are lacking, hindering the utility of proteomics in applications where the sequences are unknown including variant calling, neoepitope identification, and metaproteomics. We introduce Spectralis, a de novo peptide s...
Machine learningMass spectrometryProteome informatics
10.1038/S41467-023-44323-7
ISSN:2041-1723
Connecting multiple microenvironment proteomes uncovers the biology in head and neck cancer
Busso-Lopes Ariane F.•Neves Leandro X.•Câmara Guilherme A.•Granato Daniela C.•Pretti Marco Antônio M.等 33 人
Nature Communications
2022
•2022/11/7
•Vol.13 No.1 p.1-24
The poor prognosis of head and neck cancer (HNC) is associated with metastasis within the lymph nodes (LNs). Herein, the proteome of 140 multisite samples from a 59-HNC patient cohort, including primary and matched LN-negative or -positive tissues, saliva, and blood cells, reveals insights into the ...
Head and neck cancerMetastasisPrognostic markersProteomicsTumour biomarkers
10.1038/S41467-022-34407-1
ISSN:2041-1723
Spatiotemporal dissection of the cell cycle with single-cell proteogenomics
Diana Mahdessian•Anthony J. Cesnik•Christian Gnann•Frida Danielsson•Lovisa Stenström等 24 人
Nature
2021
•2021/2/24
•Vol.590 No.7847 p.649-654
The cell cycle, over which cells grow and divide, is a fundamental process of life. Its dysregulation has devastating consequences, including cancer1–3. The cell cycle is driven by precise regulation of proteins in time and space, which creates variability between individual proliferating cells. To ...
Cell divisionCellular imagingProtein databasesProteomics
10.1038/S41586-021-03232-9
ISSN:0028-0836
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified
Koen Debackere•Lukas Marcelis•Sofie Demeyer•Marlies Vanden Bempt•Nicole Mentens等 17 人
Nature Communications
2021
•2021/6/17
•Vol.12 No.1 p.1-19
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas with poor prognosis. Up to 30% of PTCL lack distinctive features and are classified as PTCL, not otherwise specified (PTCL-NOS). To further improve our understanding of the genetic landscape and biology of PTCL-NOS, ...
Cancer geneticsT-cell lymphoma
10.1038/S41467-021-24037-4
ISSN:2041-1723
Locus-specific induction of gene expression from heterochromatin loci during cellular senescence
Tomimatsu Kosuke•Bihary Dóra•Olan Ioana•Parry Aled J.•Schoenfelder Stefan等 20 人
Nature Aging
2021
•2021/12/23
•00 p.1-15
Senescence is a fate-determined state, accompanied by reorganization of heterochromatin. Although lineage-appropriate genes can be temporarily repressed through facultative heterochromatin, stable silencing of lineage-inappropriate genes often involves the constitutive heterochromatic mark, histone ...
AgeingChromatin structureSenescence
10.1038/S43587-021-00147-Y
ISSN:2662-8465
Alternate RNA decoding results in stable and abundant proteins in mammals
Shira Tsour•Rainer Machné•Andrew Leduc•Simon Widmer•Eunice Koo等 8 人
Nature
2026
•2026/6/24
•00 p.1-10
Amino acid substitutions may substantially alter protein stability and function1,2. However, the contribution of substitutions that arise from alternate translation (deviations from the genetic code) is unknown. Here to address this issue, we analysed deep proteomic, transcriptomic and genomic data ...
Cell biologyProteome informaticsProteomicsTranslation
10.1038/S41586-026-10678-2
ISSN:0028-0836