OTRS External Interface
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OTRS External Interface

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相关论文

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Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline

Simon WiegrebeMathias GorskiJanina M. HeroldKlaus J. StarkBarbara Thorand13
Nature Communications
2024
2024/11/20
Vol.15 No.1 p.1-13
Understanding the genetics of kidney function decline, or trait change in general, is hampered by scarce longitudinal data for GWAS (longGWAS) and uncertainty about how to analyze such data. We use longitudinal UK Biobank data for creatinine-based estimated glomerular filtration rate from 348,275 in...
Genome-wide association studiesKidney
10.1038/S41467-024-54483-9
ISSN:2041-1723

Effect of obesity on the associations of 25-hydroxyvitamin D with prevalent and incident distal sensorimotor polyneuropathy: population-based KORA F4/FF4 study

Maalmi HaifaHerder ChristianHuth CorneliaRathmann WolfgangBönhof Gidon J.11
International Journal Of Obesity
2022
2022/4/26
00 p.1-9
The association between vitamin D and DSPN has been investigated in cross-sectional studies in individuals with diabetes. However, evidence from prospective and population-based studies is still lacking. Also, the potential modifying effect of obesity and glucose tolerance has not been investigated....
ObesityRisk factors
10.1038/S41366-022-01122-2
ISSN:0307-0565

Association of the phase angle with type 2 diabetes and related traits: results from two prospective KORA studies

Feiling AiMarie-Theres HuemerWolfgang RathmannMichael RodenChristian Herder11
Nutrition & Diabetes
2026
2026/5/9
Vol.16 No.1 p.110
To investigate associations of the bioelectrical impedance analysis (BIA)-derived phase angle (PhA), an indicator of body cell mass, hydration status, and cell membrane integrity, with type 2 diabetes (T2D), prediabetes, and glycemic and insulin-related traits. Using data from the Cooperative Health...
EpidemiologyType 2 diabetes
10.1038/S41387-026-00425-X
ISSN:2044-4052

Pleiotropic effects between statin intake and inflammation parameters in two distinct population-based studies

Dennis FreuerJakob LinseisenTimo SchmitzBarbara ThorandAnnette Peters8
Communications Medicine
2025
2025/9/11
Vol.5 No.1 p.1-10
Besides their lipid lowering effects, statins exhibit numerous beneficial and adverse effects (so called pleiotropic effects). A major pleiotropic effect of statins is their anti-inflammatory properties, but the impact on a wide range of inflammation-related proteins involved in specific metabolic p...
BiomarkersEpidemiology
10.1038/S43856-025-01124-X
ISSN:2730-664X