NIMH Data Archive human subjects research data
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NIMH Data Archive
数据描述
The National Institute of Mental Health Data Archive (NDA) makes available human subjects data collected from hundreds of research projects across many scientific domains. It includes the NIMH Data Archive (NDA), the Adolescent Brain Cognitive DevelopmentSM (ABCD) Study, the Connectome Coordination Facility (CCF), the Osteoarthritis Initiative (OAI), the National Institute on Alcohol Abuse and Alcoholism Data Archive (NIAAADA), the Accelerating Medicines Partnership – Schizophrenia (AMP SCZ), the Helping to End Addiction Long-term® Initiative (HEAL), the NeuroBioBank Data Repository (NBB), and the PsychENCODE Consortium (PEC). De-identified human subjects data, harmonized to a common standard, are available to qualified researchers, while summary data are available to all.
nda.nih.gov
IP: 34.207.17.72
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2026
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2024
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2024
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Nature Neuroscience
2024
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2025
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Stress timing, trauma exposure, and family resilience differentially affect internalizing and externalizing symptoms at 3, 5, and 7 years of age
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Communications Psychology
2024
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10.1038/S44271-024-00151-Z
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Prognostic early snapshot stratification of autism based on adaptive functioning
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Nature Mental Health
2023
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A major goal of precision medicine is to predict prognosis based on individualized information at the earliest possible points in development. Using early snapshots of adaptive functioning and unsupervised data-driven discovery methods, we uncover highly stable early autism subtypes that yield infor...
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Beyond out-of-sample: robust and generalizable multivariate neuroanatomical patterns of psychiatric problems in youth
Bing Xu•Hao Wang•Lorenza Dall’Aglio•Mannan Luo•Yingzhe Zhang等 7 人
Molecular Psychiatry
2024
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Mapping differential brain structures for psychiatric problems has been challenging due to a lack of regional convergence and poor replicability in previous brain-behavior association studies. By leveraging two independent large cohorts of neurodevelopment, the ABCD and Generation R Studies (total N...
NeurosciencePsychology
10.1038/S41380-024-02855-4
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Differentiating biomarker features and familial characteristics of B-SNIP psychosis Biotypes
David A. Parker•Rebekah L. Trotti•Jennifer E. McDowell•Sarah K. Keedy•Matcheri S. Keshavan等 14 人
Translational Psychiatry
2025
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Idiopathic psychosis shows considerable biological heterogeneity across cases. The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) used psychosis-relevant biomarkers to identify psychosis Biotypes, which will aid etiological and targeted treatment investigations. Here, our previou...
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10.1038/S41398-025-03501-5
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Apathy self-awareness and its neural correlates in Parkinson’s Disease
Hannah Conn•Hideo Suzuki•Zekai Jin•Ana Marin•Xi Zhu等 10 人
Npj Parkinson's Disease
2025
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Apathy is a prevalent non-motor symptom in Parkinson’s disease (PD) that negatively impacts quality of life. Impaired self-awareness of apathy (ISA-a) further impacts patient care by limiting engagement. While apathy has been associated with reduced fronto-striatal functional connectivity (FC), the ...
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10.1038/S41531-025-01168-9
ISSN:2373-8057
Beyond discrete classifications: a computational approach to the continuum of cognition and behavior in children
Anthony Gagnon•Virginie Gillet•Anne-Sandrine Desautels•Jean-François Lepage•Andrea A. Baccarelli等 9 人
Npj Mental Health Research
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Psychiatry is undergoing a shift toward precision medicine, demanding personalized approaches that capture the complexity of cognition and behavior. Here, we introduce a novel referential of four robust, replicable, and generalizable cognitive and behavioral profiles. These were derived from a large...
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Associations between media parenting practices and early adolescent screen use
Jason M. Nagata•Angel Paul•Felicia Yen•Zacariah Smith-Russack•Iris Yuefan Shao等 11 人
Pediatric Research
2024
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To assess the prevalence of various media parenting practices and identify their associations with early adolescent screen time and problematic social media, video game, and mobile phone use. Cross-sectional data from Year 3 of the Adolescent Brain Cognitive Development (ABCD) Study (2019–2022) that...
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10.1038/S41390-024-03243-Y
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Identity-by-descent analysis of a large Tourette’s syndrome pedigree from Costa Rica implicates genes involved in neuronal development and signal transduction
Ryan Niamh•Ormond Cathal•Chang Yi-Chieh•Contreras Javier•Raventos Henriette等 9 人
Molecular Psychiatry
2022
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Tourette Syndrome (TS) is a heritable, early-onset neuropsychiatric disorder that typically begins in early childhood. Identifying rare genetic variants that make a significant contribution to risk in affected families may provide important insights into the molecular aetiology of this complex and h...
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Pablo Andrés-Camazón•Covadonga M. Diaz-Caneja•Ram Ballem•Jiayu Chen•Vince D. Calhoun等 6 人
Schizophrenia
2025
•2025/3/19
•Vol.11 No.1 p.1-14
Understanding neurobiology and developing effective interventions for cognitive dysfunction in psychotic disorders remain elusive. Insufficient knowledge about the biological heterogeneity of cognitive dysfunction hinders progress. We aimed to identify subgroups of patients with psychosis and distin...
BiomarkersHuman behaviourPsychosisSchizophrenia
10.1038/S41537-025-00593-2
ISSN:2754-6993
The impact of targeted cathodal transcranial direct current stimulation on reward circuitry and affect in Bipolar Disorder
M. A. Bertocci•H. W. Chase•S. Graur•R. Stiffler•E. K. Edmiston等 8 人
Molecular Psychiatry
2019
•2019/10/29
•00 p.1-9
Bipolar Disorder is costly and debilitating, and many treatments have side effects. Transcranial Direct Current Stimulation (tDCS) is a well-tolerated neuromodulation technique that may be a useful treatment for Bipolar Disorder if targeted to neural regions implicated in the disorder. One potential...
Bipolar disorderNeuroscience
10.1038/S41380-019-0567-1
ISSN:1359-4184
Concerted elevations of cortical and striatal glutamate and GABA in antipsychotic-free individuals at clinical high-risk for psychosis
Ragy R. Girgis•Camilo de la Fuente-Sandoval•Roberto Lewis-Fernández•Francisco Reyes-Madrigal•Melanie M. Wall等 10 人
Neuropsychopharmacology
2025
•2025/9/25
•00 p.1-9
While the literature on glutamate and γ-aminobutyric acid (GABA) levels as measured by proton magnetic spectroscopy (1H MRS) in psychosis is somewhat mixed, replicated findings from our group and others suggest that antipsychotic medication status is a critical factor in study outcomes, with cohorts...
BiomarkersNeuroscience
10.1038/S41386-025-02251-8
ISSN:0893-133X
Learning MRI artefact removal with unpaired data
Siyuan Liu•Kim-Han Thung•Liangqiong Qu•Weili Lin•Dinggang Shen等 6 人
Nature Machine Intelligence
2021
•2021/1/19
•Vol.3 No.1 p.60-67
Retrospective artefact correction (RAC) improves image quality post acquisition and enhances image usability. Recent machine-learning-driven techniques for RAC are predominantly based on supervised learning, so practical utility can be limited as data with paired artefact-free and artefact-corrupted...
Image processingMachine learning
10.1038/S42256-020-00270-2
ISSN:2522-5839
Mapping recurrent mosaic copy number variation in human neurons
Chen Sun•Kunal Kathuria•Sarah B. Emery•ByungJun Kim•Ian E. Burbulis等 11 人
Nature Communications
2024
•2024/5/17
•Vol.15 No.1 p.1-13
When somatic cells acquire complex karyotypes, they often are removed by the immune system. Mutant somatic cells that evade immune surveillance can lead to cancer. Neurons with complex karyotypes arise during neurotypical brain development, but neurons are almost never the origin of brain cancers. I...
Genetics of the nervous systemMolecular neuroscience
10.1038/S41467-024-48392-0
ISSN:2041-1723
Functional hierarchy of the human neocortex across the lifespan
Hoyt Patrick Taylor•Khoi Minh Huynh•Kim-Han Thung•Guoye Lin•Wenjiao Lyu等 8 人
Nature
2026
•2026/3/25
•00 p.1-10
Large-scale gradients of functional connectivity between brain areas organize the human neocortex, linking brain topography to the texture of cognition1,2. In adults, three dominant axes—sensory–association, visual–somatosensory and modulation–representation—run, respectively, from primary sensory t...
Computational biology and bioinformaticsComputational neuroscience
10.1038/S41586-026-10219-X
ISSN:0028-0836
Change in striatal functional connectivity networks across 2 years due to stimulant exposure in childhood ADHD: results from the ABCD sample
Adam Kaminski•Hua Xie•Brylee Hawkins•Chandan J. Vaidya
Translational Psychiatry
2024
•2024/11/6
•Vol.14 No.1 p.1-11
Widely prescribed for Attention-Deficit/Hyperactivity Disorder (ADHD), stimulants (e.g., methylphenidate) have been studied for their chronic effects on the brain in prospective designs controlling dosage and adherence. While controlled approaches are essential, they do not approximate real-world st...
ADHDNeuroscience
10.1038/S41398-024-03165-7
ISSN:2158-3188
Functional connectivity development along the sensorimotor-association axis enhances the cortical hierarchy
Audrey C. Luo•Valerie J. Sydnor•Adam Pines•Bart Larsen•Aaron F. Alexander-Bloch等 27 人
Nature Communications
2024
•2024/4/25
•Vol.15 No.1 p.1-16
Human cortical maturation has been posited to be organized along the sensorimotor-association axis, a hierarchical axis of brain organization that spans from unimodal sensorimotor cortices to transmodal association cortices. Here, we investigate the hypothesis that the development of functional conn...
Development of the nervous systemFunctional magnetic resonance imaging
10.1038/S41467-024-47748-W
ISSN:2041-1723
Krakencoder: a unified brain connectome translation and fusion tool
Keith W. Jamison•Zijin Gu•Qinxin Wang•Ceren Tozlu•Mert R. Sabuncu等 6 人
Nature Methods
2025
•2025/6/5
•00 p.1-10
Brain connectivity can be estimated in many ways, depending on modality and processing strategy. Here, we present the Krakencoder, a joint connectome mapping tool that simultaneously bidirectionally translates between structural and functional connectivity, and between different atlases and processi...
Computational neuroscienceNeuroscience
10.1038/S41592-025-02706-2
ISSN:1548-7091
Caregiver report of infant behavior associated with autism likelihood in first year of life
Erin M. Andres•Shaina P. Brady•Italia Camillone•Casey A. Cragin•Melissa A. Clark等 8 人
Pediatric Research
2025
•2025/1/22
•00 p.1-10
Identification of prodromal indicators of autism in infancy has the potential to identify behaviors relevant to early autism screening. We report on data from a prospective general population birth cohort with maternal reported measures at 9 and 12 months: the Survey of Well-Being of Young Children ...
Medicine/Public Health, generalPediatricsPediatric Surgery
10.1038/S41390-025-03867-8
ISSN:0031-3998
Latent space-based network analysis for brain–behavior linking in neuroimaging
Selena Wang•Xinzhi Zhang•Yunhe Liu•Wanwan Xu•Xinyuan Tian等 6 人
Nature Methods
2025
•2025/12/4
•00 p.1-11
We propose a latent space-based statistical network analysis (LatentSNA) method that implements network science in a generative Bayesian framework, preserves neurologically meaningful brain topology and improves statistical power for imaging biomarker detection. LatentSNA (1) addresses the lack of p...
Network topologyStatistical methods
10.1038/S41592-025-02896-9
ISSN:1548-7091
A shifting role of thalamocortical connectivity in the emergence of cortical functional organization
Shinwon Park•Koen V. Haak•Stuart Oldham•Hanbyul Cho•Kyoungseob Byeon等 15 人
Nature Neuroscience
2024
•2024/6/10
•00 p.1-11
The cortical patterning principle has been a long-standing question in neuroscience, yet how this translates to macroscale functional specialization in the human brain remains largely unknown. Here we examine age-dependent differences in resting-state thalamocortical connectivity to investigate its ...
BrainNetwork modelsNeuronal developmentNeuroscience
10.1038/S41593-024-01679-3
ISSN:1097-6256
A network-based analysis anticipates time to recovery from major depression revealing a plasticity by context interplay
Claudia Delli Colli•Aurelia Viglione•Silvia Poggini•Francesca Cirulli•Flavia Chiarotti等 7 人
Translational Psychiatry
2025
•2025/1/28
•Vol.15 No.1 p.1-7
Predicting disease trajectories in patients with major depressive disorder (MDD) can allow designing personalized therapeutic strategies. In this study, we aimed to show that measuring patients’ plasticity – that is the susceptibility to modify the mental state – identifies at baseline who will reco...
DepressionHuman behaviour
10.1038/S41398-025-03246-1
ISSN:2158-3188
Neural representations of anxiety in adolescents with anorexia nervosa: a multivariate approach
René Seiger•Nicco Reggente•D.S.-Adnan Majid•Ronald Ly•Reza Tadayonnejad等 7 人
Translational Psychiatry
2023
•2023/8/15
•Vol.13 No.1 p.1-11
Anorexia nervosa (AN) is characterized by low body weight, fear of gaining weight, and distorted body image. Anxiety may play a role in the formation and course of the illness, especially related to situations involving food, eating, weight, and body image. To understand distributed patterns and con...
NeurosciencePsychiatric disorders
10.1038/S41398-023-02581-5
ISSN:2158-3188
A multifaceted gradient in human cerebellum of structural and functional development
Liu Xingyu•d’Oleire Uquillas Federico•Viaene Angela N.•Zhen Zonglei•Gomez Jesse
Nature Neuroscience
2022
•2022/8/18
•Vol.25 No.9 p.1129-1133
The organization of the basic tissue and functional properties of the cerebellum across development is unknown. Combining several large datasets, we demonstrate in the human cerebellum a static tissue gradient in adults that mirrors a similar growth-rate gradient across development. Quantitative tis...
CerebellumCognitive neuroscienceDevelopment of the nervous system
10.1038/S41593-022-01136-Z
ISSN:1097-6256
Spatial heterogeneity and subtypes of functional connectivity development in youth
Hongming Li•Zaixu Cui•Matthew Cieslak•Taylor Salo•Tyler M. Moore等 12 人
Nature Communications
2026
•2026/1/23
•Vol.17 No.1 p.19560
Brain age prediction has been widely utilized to assess functional connectivity (FC) development, but conventional global brain age indices are limited in capturing spatial heterogeneity across the cortex. This study introduces a regional brain development index to characterize fine-grained FC matur...
Cognitive neuroscienceDevelopment of the nervous systemFunctional magnetic resonance imagingMachine learning
10.1038/S41467-026-68707-7
ISSN:2041-1723
Anxiety-focused cognitive behavioral therapy delivered by non-specialists to prevent postnatal depression: a randomized, phase 3 trial
Pamela J. Surkan•Abid Malik•Jamie Perin•Najia Atif•Armaan Rowther等 7 人
Nature Medicine
2024
•2024/2/16
•00 p.1-8
Anxiety experienced by women during pregnancy is highly prevalent, especially in resource-poor settings and strongly predicts postnatal common mental disorders (CMDs), anxiety and depression. We evaluated the effectiveness of an anxiety-focused early prenatal intervention on preventing postnatal CMD...
Outcomes researchPatient educationPreventive medicine
10.1038/S41591-024-02809-X
ISSN:1078-8956
Lifespan reference curves for harmonizing multi-site regional brain white matter metrics from diffusion MRI
Alyssa H. Zhu•Talia M. Nir•Shayan Javid•Julio E. Villalón-Reina•Amanda L. Rodrigue等 17 人
Scientific Data
2025
•2025/5/6
•Vol.12 No.1 p.1-18
Age-related white matter (WM) microstructure maturation and decline occur throughout the human lifespan, complementing the process of gray matter development and degeneration. Here, we create normative lifespan reference curves for global and regional WM microstructure by harmonizing diffusion MRI (...
Computational neuroscienceDevelopment of the nervous systemNeuroscienceSoftwareStandards
10.1038/S41597-025-05028-2
ISSN:2052-4463
Brain functional-structural gradient coupling reflects development, behavior and genetic influences
Simiao Gao•Zhiling Gu•Shengxian Ding•Gefei Wang•Zhengwu Zhang等 7 人
Nature Communications
2026
•2026/4/9
0Gradients provide low-dimensional representations of macroscale brain organization, yet how structural-functional gradient coupling develops and relates to behavioral and molecular features remains unclear. Here, we studied structural-functional gradient coupling across multiple metrics and spatial ...
Neural patterningPredictive markers
10.1038/S41467-026-71719-Y
ISSN:2041-1723
Schooling substantially improves intelligence, but neither lessens nor widens the impacts of socioeconomics and genetics
Judd Nicholas•Sauce Bruno•Klingberg Torkel
Npj Science Of Learning
2022
•2022/12/15
•Vol.7 No.1 p.1-9
Schooling, socioeconomic status (SES), and genetics all impact intelligence. However, it is unclear to what extent their contributions are unique and if they interact. Here we used a multi-trait polygenic score for cognition (cogPGS) with a quasi-experimental regression discontinuity design to isola...
Human behaviourIntelligence
10.1038/S41539-022-00148-5
ISSN:2056-7936
Musical rhythm abilities and risk for developmental speech-language problems and disorders: epidemiological and polygenic associations
Srishti Nayak•Enikő Ladányi•Else Eising•Yasmina Mekki•Rachana Nitin等 15 人
Nature Communications
2025
•2025/9/24
•Vol.16 No.1 p.1-13
Impaired musical rhythm abilities and developmental speech-language related disorders are biologically and clinically intertwined. Prior work examining their relationship has primarily used small samples; here, we studied associations at population-scale by conducting the largest systematic epidemio...
Human behaviourPersonalized medicineRisk factorsSensorimotor processing
10.1038/S41467-025-60867-2
ISSN:2041-1723
Effects of a virtual voice-based coach delivering problem-solving treatment on emotional distress and brain function: a pilot RCT in depression and anxiety
Thomas Kannampallil•Olusola A. Ajilore•Nan Lv•Joshua M. Smyth•Nancy E. Wittels等 18 人
Translational Psychiatry
2023
•2023/5/12
•Vol.13 No.1 p.1-8
Consumer-based voice assistants have the ability to deliver evidence-based treatment, but their therapeutic potential is largely unknown. In a pilot trial of a virtual voice-based coach, Lumen, delivering problem-solving treatment, adults with mild-to-moderate depression and/or anxiety were randomiz...
DepressionEpigenetics and behaviour
10.1038/S41398-023-02462-X
ISSN:2158-3188
Psychiatric predictors of first-onset suicidal thoughts and behaviors throughout preadolescence: longitudinal associations in a US population-based study
Rachel F. L. Walsh•Ana E. Sheehan•Taylor A. Burke•Richard T. Liu
Translational Psychiatry
2026
•2026/4/6
0Rates of suicidal thoughts and behaviors are increasing among preadolescent children, yet there is a paucity of longitudinal research among this developmental group. This study evaluated prospective associations between current and lifetime psychiatric disorders and first-onset suicidal ideation (SI...
Human behaviourPsychiatric disorders
10.1038/S41398-026-03980-0
ISSN:2158-3188
Imbalanced social-communicative and restricted repetitive behavior subtypes of autism spectrum disorder exhibit different neural circuitry
Natasha Bertelsen•Isotta Landi•Richard A. I. Bethlehem•Jakob Seidlitz•Elena Maria Busuoli等 35 人
Communications Biology
2021
•2021/5/14
•Vol.4 No.1 p.1-13
Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify h...
Autism spectrum disorders
10.1038/S42003-021-02015-2
ISSN:2399-3642
The effective connectome over a century of human life
Guoshi Li•Khoi Minh Huynh•Kim-Han Thung•Hoyt Patrick Taylor IV•Guoye Lin等 8 人
Communications Biology
2025
•2025/11/24
•Vol.8 No.1 p.16380
Brain functional connectomes describe the coordination principles of neural systems. Understanding normative developmental connectomes is crucial for standardized growth assessment and early disease detection. However, functional connectome has been mostly studied using undirected functional connect...
Computational neuroscienceDevelopment of the nervous system
10.1038/S42003-025-08970-4
ISSN:2399-3642
Temporally distinct 3D multi-omic dynamics in the developing human brain
Matthew G. Heffel•Jingtian Zhou•Yi Zhang•Dong-Sung Lee•Kangcheng Hou等 30 人
Nature
2024
•2024/10/9
•00 p.1-9
The human hippocampus and prefrontal cortex play critical roles in learning and cognition1,2, yet the dynamic molecular characteristics of their development remain enigmatic. Here we investigated the epigenomic and three-dimensional chromatin conformational reorganization during the development of t...
Cell type diversityChromatin structure
10.1038/S41586-024-08030-7
ISSN:0028-0836
Towards a network-based operationalization of plasticity for predicting the transition from depression to mental health
Claudia Delli Colli•Flavia Chiarotti•Patrizia Campolongo•Alessandro Giuliani•Igor Branchi
Nature Mental Health
2024
•2024/1/15
•00 p.1-9
Plasticity is the ability to modify brain and behavior and allows the transition from psychopathology to mental wellbeing. High plasticity has been associated with high susceptibility to contextual factors, for example, living conditions, which ultimately drive the plasticity outcome. Here we exploi...
DepressionPredictive markers
10.1038/S44220-023-00192-Z
ISSN:2731-6076
The effects of adverse life events on brain development in the ABCD study®: a propensity-weighted analysis
Amanda Elton•Ben Lewis•Sara Jo Nixon
Molecular Psychiatry
2024
•2024/11/22
•00 p.1-12
Longitudinal studies of the effects of adversity on human brain development are complicated by the association of stressful events with confounding variables. To counter this bias, we apply a propensity-weighted analysis of the first two years of The Adolescent Brain Cognitive DevelopmentSM (ABCD) S...
NeurosciencePredictive markers
10.1038/S41380-024-02850-9
ISSN:1359-4184
Pre-treatment clinical and gene expression patterns predict developmental change in early intervention in autism
Lombardo Michael V.•Busuoli Elena Maria•Schreibman Laura•Stahmer Aubyn C.•Pramparo Tiziano等 14 人
Molecular Psychiatry
2021
•2021/8/2
•00 p.1-11
Early detection and intervention are believed to be key to facilitating better outcomes in children with autism, yet the impact of age at treatment start on the outcome is poorly understood. While clinical traits such as language ability have been shown to predict treatment outcome, whether or not a...
Autism spectrum disordersNeuroscience
10.1038/S41380-021-01239-2
ISSN:1359-4184
Neuroanatomical subtypes of preterm adolescents
Weibin Ji•Guanya Li•Yang Hu•Wenchao Zhang•Yuefeng Li等 12 人
Molecular Psychiatry
2026
•2026/7/9
•00 p.1-10
Preterm infants have a higher risk for developing neurocognitive deficits and behavioral abnormalities across the lifespan, but the individual long-term neurobiological heterogeneity presents a challenge for developmental risk assessment and outcome prediction. Thus, we took advantage of the large s...
NeurosciencePredictive markers
10.1038/S41380-026-03741-X
ISSN:1359-4184
Rationale and Methods for the Prospective Genetic Risk Evaluation and Assessment (PROGRESS) in Autism Center at Columbia University
Nicolò Pini•Lauren C. Shuffrey•Kally C. O’Reilly Sparks•Andrew T. Marin•Celia L. D’Amato等 21 人
Pediatric Research
2026
•2026/7/22
•00 p.1-10
Autism is most often diagnosed after the age of 3, despite evidence that neurodevelopmental differences emerge within the first 2 years of life and that genetic and familial risk can be identified at birth. Established in September 2022 (anticipated duration of 5–7 years), the Prospective Genet...
Medicine/Public Health, generalPediatricsPediatric Surgery
10.1038/S41390-026-05204-Z
ISSN:0031-3998
Replication of a neuroimaging biomarker for striatal dysfunction in psychosis
Jose M. Rubio•Todd Lencz•Hengyi Cao•Nina Kraguljac•Elvisha Dhamala等 14 人
Molecular Psychiatry
2024
•2024/1/4
•00 p.1-10
To bring biomarkers closer to clinical application, they should be generalizable, reliable, and maintain performance within the constraints of routine clinical conditions. The functional striatal abnormalities (FSA), is among the most advanced neuroimaging biomarkers in schizophrenia, trained to dis...
Diagnostic markersSchizophrenia
10.1038/S41380-023-02381-9
ISSN:1359-4184
Excess BMI in early adolescence adversely impacts maturating functional circuits supporting high-level cognition and their structural correlates
Brooks Skylar J.•Smith Calli•Stamoulis Catherine
International Journal Of Obesity
2023
•2023/4/3
•00 p.1-16
Adverse effects of excess BMI (affecting 1 in 5 children in the US) on brain circuits during neurodevelopmentally vulnerable periods are incompletely understood. This study investigated BMI-related alterations in maturating functional networks and their underlying brain structures, and high-level co...
Cognitive neurosciencePhysiology
10.1038/S41366-023-01303-7
ISSN:0307-0565
Limited generalizability of multivariate brain-based dimensions of child psychiatric symptoms
Bing Xu•Lorenza Dall’Aglio•John Flournoy•Gerda Bortsova•Brenden Tervo-Clemmens等 12 人
Communications Psychology
2024
•2024/2/28
•Vol.2 No.1 p.1-14
Multivariate machine learning techniques are a promising set of tools for identifying complex brain-behavior associations. However, failure to replicate results from these methods across samples has hampered their clinical relevance. Here we aimed to delineate dimensions of brain functional connecti...
Magnetic resonance imagingPredictive markers
10.1038/S44271-024-00063-Y
ISSN:2731-9121
Cognitive and psychiatric relevance of dynamic functional connectivity states in a large (N > 10,000) children population
Zening Fu•Jing Sui•Armin Iraji•Jingyu Liu•Vince D. Calhoun
Molecular Psychiatry
2024
•2024/7/31
•00 p.1-12
Children’s brains dynamically adapt to the stimuli from the internal state and the external environment, allowing for changes in cognitive and mental behavior. In this work, we performed a large-scale analysis of dynamic functional connectivity (DFC) in children aged 9~11 years, investigating how br...
ADHDNeurosciencePredictive markersPsychology
10.1038/S41380-024-02683-6
ISSN:1359-4184
Non-invasively targeting, probing and modulating a deep brain circuit for depression alleviation
Desmond J. Oathes•Romain J-P. Duprat•Justin Reber•Ximo Liang•Morgan Scully等 9 人
Nature Mental Health
2023
•2023/11/27
•Vol.1 No.12 p.1033-1042
Effective repetitive transcranial magnetic stimulation (rTMS) treatment for depression has often focused on modulating the subgenual anterior cingulate cortex (sgACC), but no studies have related TMS-evoked responses in the sgACC to clinical effects following rTMS. Here we use interleaved single-pul...
DepressionPrognostic markers
10.1038/S44220-023-00165-2
ISSN:2731-6076
Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling
Ibrahim Karim•Noble Stephanie•He George•Lacadie Cheryl•Crowley Michael J.等 8 人
Molecular Psychiatry
2021
•2021/10/25
•00 p.1-15
Disruptions in frontoparietal networks supporting emotion regulation have been long implicated in maladaptive childhood aggression. However, the association of connectivity between large-scale functional networks with aggressive behavior has not been tested. The present study examined whether the fu...
NeurosciencePredictive markers
10.1038/S41380-021-01317-5
ISSN:1359-4184
Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder
Louisa Schilling•S. Parker Singleton•Ceren Tozlu•Marie Hédo•Qingyu Zhao等 8 人
Nature Mental Health
2025
•2025/11/21
•00 p.1-19
An individual’s risk of substance use disorder (SUD) is shaped by potent biosocial factors. Family history is one of the strongest predictors, yet its impact on the brain before substance exposure remains unclear. Here we apply network control theory to estimate transition energies (TEs)—the input r...
Computational neuroscienceDevelopment of the nervous system
10.1038/S44220-025-00523-2
ISSN:2731-6076
Predictive value of subgenual cingulate normative connectivity to TMS treatment site for antidepressant response in routine clinical practice: a prospective, multisite cohort study
Sanaz Khosravani•Stephan T. Palm•William Drew•Summer B. Frandsen•Christopher Lin等 20 人
Molecular Psychiatry
2025
•2025/8/22
•00 p.1-12
Small single-site studies found that transcranial magnetic stimulation (TMS) targets with better antidepressant response were more negatively functionally connected to the subgenual cingulate cortex (SGC). These led to “anti-subgenual” TMS targeting in recent clinical trials. We conducted a larger p...
DepressionNeuroscience
10.1038/S41380-025-03153-3
ISSN:1359-4184
Multifaceted atlases of the human brain in its infancy
Ahmad Sahar•Wu Ye•Wu Zhengwang•Thung Kim-Han•Liu Siyuan等 9 人
Nature Methods
2022
•2022/12/30
•Vol.20 No.1 p.55-64
Brain atlases are spatial references for integrating, processing, and analyzing brain features gathered from different individuals, sources, and scales. Here we introduce a collection of joint surface–volume atlases that chart postnatal development of the human brain in a spatiotemporally dense mann...
Computational neuroscienceImage processingMagnetic resonance imaging
10.1038/S41592-022-01703-Z
ISSN:1548-7091
Two axes of white matter development
Audrey C. Luo•Steven L. Meisler•Valerie J. Sydnor•Aaron Alexander-Bloch•Joëlle Bagautdinova等 28 人
Nature Communications
2026
•2026/1/23
•Vol.17 No.1 p.19570
Despite decades of neuroimaging research, how white matter develops along the length of major tracts in humans remains unknown. Here, we identify fundamental patterns of white matter maturation by examining developmental variation along major, long-range cortico-cortical tracts in youth ages 5-23 ye...
Development of the nervous systemNeuroscience
10.1038/S41467-026-68714-8
ISSN:2041-1723
Autism subtypes identified using cross-species functional connectivity analyses
Marco Pagani•Valerio Zerbi•Silvia Gini•Filomena Grazia Alvino•Abhishek Banerjee等 23 人
Nature Neuroscience
2026
•2026/5/15
•00 p.1-12
It is often assumed that phenotypic heterogeneity in autism reflects underlying pathobiological variation. However, direct evidence supporting this link is lacking. Leveraging cross-species functional neuroimaging, we show that brain dysconnectivity patterns in autism can be parsed into biologically...
Autism spectrum disordersFunctional magnetic resonance imaging
10.1038/S41593-026-02287-Z
ISSN:1097-6256